What are the neurophysiological correlates of paired associative stimulation (PAS) in inducing plastic changes in human motor cortex (M1)? Here, Arrigoni and colleagues (2024) will apply transcranial magnetic stimulation (TMS) to left M1 paired with electrical stimulation of the right median nerve at an ISI of 25 ms or 10 ms to induce long-term potentiation (LTP) or long-term depression (LTD), respectively. Arrigoni and colleagues (2024) will determine if these stimulation pairings effect cortical excitability using motor-evoked potentials (MEPs) and TMS-evoked potentials (TEPs). Specifically, they hypothesize PASLTP will increase the peak-to-peak amplitude of MEPs, whereas PASLTD will decrease the amplitude, replicating previous work. They will then extend these previous findings by examining TEPs. The authors anticipate modulation of the P30 and P60, which are TEPs thought to reflect local cortical excitability. They plan to account for the MEP reafference which may also mediate the P60 amplitude by stimulating at sub- and supra- motor threshold. Further, they hypothesize an increase of the N100, a marker of inhibitory processing mediated by GABA, by PASLTD. Finally, the authors will also examine the impact of cortical excitability over time to determine the duration of the PAS effects.   

 

This detailed examination of TEPs following PAS stimulation will determine which TEPs could be used as biomarkers with the induction of LTP and LTD through stimulation. The authors have built in an MEP replication for the PAS stimulation, supporting previous literature and acting as a positive control.  

 

The Stage 1 manuscript was evaluated by three expert reviewers across two rounds. Following in-depth review and responses from the authors, the recommender determined that Stage 1 criteria was met and awarded in-principle acceptance (IPA).

 

URL to the preregistered Stage 1 protocol: https://osf.io/detjc (under temporary private embargo)
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:

 

References
 
1. Arrigoni, E., Bolognini, N., Pisoni, A. & Guidali, G. (2024). Neurophysiological correlates of plasticity induced by paired associative stimulation (PAS) targeting the motor cortex: a TMS-EEG registered report. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/detjc

The Temporal Doppler Effect refers to the subjective perception that the past is further away than the future even when both temporal distances are objectively the same from the present moment (Caruso et al., 2013). In the current study, Zhang et al. ran a replication of this phenomenon and tested one possible explanation for it, namely that people overestimate the temporal distance of the past because the past is filled with more events than the future. This is because we can access information only about planned events for the future, but have access to both planned and unplanned events that happened in the past (filled-duration illusion; Thomas & Brown, 1974).

 

Over two studies, the authors found that the sampled participants reported feeling that the past was psychologically closer than the future, which is the opposite of what has previously been reported and termed the Temporal Doppler Effect (Caruso et al., 2013). In addition, the authors reported inconsistent results regarding the correlations between the psychological distance and different variables associated with the filling rate of duration. The authors discuss the differences between their own results and those by Caruso et al. (2013) in terms of methodological and contextual differences and highlight cultural aspects that may be critical to consider in future replications and overall testing of this phenomenon. As such, they highlight that, at the moment, the Temporal Doppler Effect should not be considered a robust and culturally universal phenomenon. 

 

The Stage 2 manuscript was evaluated by two reviewers who had also reviewed the stage 1 report. Following a revision by the authors, which consisted of adding the Data Availability statement, as well as a more precise summary of the results in various sections of the report, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.

 

URL to the preregistered Stage 1 protocol: https://osf.io/d9ec3/
 
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question existed prior to Stage 1 in-principle acceptance. 

 

 

 

1. Caruso, E. M., Van Boven, L., Chin, M., & Ward, A. (2013). The temporal doppler effect: When the future feels closer than the past. Psychological Science, 24, 530-536. https://doi.org/10.1177/0956797612458804 

 

2. Thomas, E. C., & Brown, I. (1974). Time perception and the filled-duration illusion. Perception & Psychophysics, 16, 449-458. https://doi.org/10.3758/BF03198571 

 

3. Zhang, Q., Masuda, Y., Ueda, K.,Toda, K., & Yamada, Y. (2022). Is the past farther than the future? A registered replication and test of the time-expansion hypothesis based on the filling rate of duration. Stage 2 Registered Report, acceptance of Version 2 by Peer Community in Registered Reports. https://psyarxiv.com/pb47n/ 

 

Borderline personality disorder (BPD) is a mental illness affecting ~1 in 100 people (Ellison et al., 2018), characterised by emotional dysregulation, impulsivity, a distorted sense of self, and a long-term pattern of unstable interpersonal relationships. Among this heterogenous range of symptoms is difficulty in the cognitive dimension of empathy, in particular understanding the perspectives of others, which in turn has been suggested to rely on the mirror neuron system, both in the motor and somatosensory domains. The integrity of the mirror system has therefore been a focus for understanding the possible causes or consequences of the disorder, with preliminary studies pointing to hypoactivity of neuronal areas associated with the mirror system in BPD (Mier et al., 2013).

 

In the current study, Zazio et al. (2023) will use crossmodal paired associative stimulation (cm-PAS) in which an image of a hand being touched is repeatedly paired with transcranial magnetic stimulation (TMS) of the primary somatosensory cortex (S1) to test the hypothesis that BPD is associated with a specific deficit in the tactile mirror system. In healthy controls, the close temporal coupling (20ms) between the visual depiction of tactile stimulation and TMS of S1 is expected boost tactile acuity and elevate the performance cost of incongruence in a task that manipulates visuo-tactile spatial congruity (VTSC) – effects that are thought to reflect the fidelity of the tactile mirror system.

 

In BPD patients, however, the authors make the crucial prediction that impairment of the tactile mirror system (if present) will lead to a reduced (or even non-existent) effect of cm-PAS on tactile acuity and VTSC task performance compared to healthy controls. To help ensure a severe test of this hypothesis, the design includes a variety of controls, including an attention check, control cm-PAS in which the inter-stimulus interval is increased to 100ms to break the close temporal coupling between visual stimulation and TMS, and a positive control to confirm that active cm-PAS (compared to control cm-PAS) produces the expected boost in tactile acuity in healthy controls.

 

The Stage 1 manuscript was evaluated over three rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).

 

URL to the preregistered Stage 1 protocol: https://osf.io/ge2rm
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 

References
 

1. Ellison, W. D., Rosenstein, L. K., Morgan, T. A., & Zimmerman, M. (2018). Community and clinical epidemiology of borderline personality disorder. Psychiatric Clinics, 41, 561-573. https://doi.org/10.1016/j.psc.2018.07.008

2. Mier, D., Lis, S., Esslinger, C., Sauer, C., Hagenhoff, M., Ulferts, J., Gallhofer, B. & Kirsch, P. (2013). Neuronal correlates of social cognition in borderline personality disorder. Social Cognitive and Affective Neuroscience, 8, 531-537. https://doi.org/10.1093/scan/nss028

 

2. Zazio, A., Guidali, G., Rossi, R., Bolognini, N. & Bortoletto, A. (2023). Cortical plasticity of the tactile mirror system in borderline personality disorder, in principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/ge2rm

Subjective tinnitus is a common disorder in which people experience a persistent sound in the absence of any external source. The underlying causes of tinnitus are debated – although the condition is strongly associated with hearing loss resulting from auditory damage, much remains to be understood about the neural processes that give rise to the phantom perception. Various classes of neurophysiological theories have been proposed, including the “altered gain” model – in which neurons in the auditory pathway increase their responsiveness to compensate for reduced auditory input following hearing loss – and the “noise cancellation” model –  in which disrupted feedback connections from limbic regions are unable to tune out phantom signals. Although these theories account for much observed data, they have not been conclusively supported, and their ability to explain tinnitus is limited by the fact that hearing loss and tinnitus can arise independently and at different times.

 

In the current study, Reisinger et al. (2023) will test an emerging alternative theory based on a Bayesian predictive-coding framework (Sedley et al., 2016) in which the alteration of perceptual priors leads the auditory system to expect a sound that, if functioning normally, it should not expect. Using magnetoencephalography (MEG) in a sample of tinnitus patients (and carefully-matched controls for age, gender, and level of hearing loss), they will ask whether tinnitus is associated with anticipatory brain activation, tuned to the carrier-frequency of an expected auditory stimulus. Specifically, the authors predict that if the predictive-coding framework is correct then individuals with tinnitus should show different regularity-dependent pre-activations of carrier- frequency-specific information compared to the control group, while tone carrier-frequencies should be processed normally in tinnitus patients. They also predict that any such pre-activations should not be related to levels of reported subjective tinnitus distress, as measured with the short version of the Tinnitus Questionnaire (mini-TQ).

 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).

 

 

Level of bias control achieved: Level 3. At least some data/evidence that will be used to the answer the research question has been previously accessed by the authors (e.g. downloaded or otherwise received), but the authors certify that they have not yet observed ANY part of the data/evidence.

 

 

• Brain and Neuroscience Advances
• Cortex
• F1000Research
• In&Vertebrates
• NeuroImage: Reports
• Peer Community Journal
• PeerJ
• Psychology of Consciousness: Theory, Research and Practice
• Royal Society Open Science

 

 

Reisinger, L., Demarchi, G., Rösch, , S., Trinka, E., Obleser, L., & Weisz, N.  (2023). Registered Report: Are anticipatory predictions enhanced in tinnitus and independent of hearing loss? In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/6gvpy

 

Sedley, W., Friston, K. J., Gander, P. E., Kumar, S., & Griffiths, T. D. (2016). An integrative tinnitus model based on sensory precision. Trends in Neurosciences, 39, 799-812. https://doi.org/10.1016/j.tins.2016.10.004

For centuries, the relationship between creativity and mental health has been a subject of fascination, propelled by the impression that many of the most famous artists in history likely suffered from mood disorders or other mental illnesses. However, with the advent of psychological science – including more precise and diagnostic clinical measures – the empirical evidence for an association between creativity and depressive symptoms has been mixed, with some studies suggesting a positive relationship and others showing either no effect or indicating that the link, if there is one, may be driven by other personality characteristics (Verhaeghen et al., 2005).

 

In the current study, Lam and Saunders will use an online design in 200 participants to ask whether creativity is associated with higher depressive traits, and further, whether that relationship depends on two additional variables that could explain an observed positive correlation: self-reflective rumination (repetitive thoughts that maintain a negative mood state) and the frequency with which individuals engage in reappraisal (a regulation strategy that involves reinterpreting an event or situation to diminish its negative impact). If justified by the main confirmatory findings, the authors will also explore the moderating role of gender and how any observed associations are reflected in more fine-grained measures of creativity. The results promise to shed light on not only the basic question of whether creativity is related to depressive traits, but the extent to which that association depends on related determinants of mental health.

 

Following two rounds of in-depth review, the recommender judged that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).  

 

URL to the preregistered Stage 1 protocol: https://osf.io/yub7n
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:
 

References
 

1. Verhaeghen, P., Joormann, J., & Khan, R. (2005). Why we sing the blues: The relation between self-reflective rumination, mood, and creativity. Emotion, 5(2), 226-232. https://doi.org/10.1037/1528-3542.5.2.226

 

2. Lam, C. Y. & Saunders, J. A. (2022). Relationship between creativity and depression: the role of reappraisal and rumination, in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/yub7n