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IdTitle * Authors * Abstract * PictureThematic fields * RecommenderReviewersSubmission date
28 Feb 2024
STAGE 2
(Go to stage 1)

Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting quality

Evidence for mixed quality of systematic reviews in preclinical animal studies of neurodevelopmental conditions

Recommended by ORCID_LOGO based on reviews by Marietta Papadatou-Pastou
Single gene alterations have been estimated to account for nearly half of neurodevelopmental conditions (NDCs), providing a crucial opportunity for animal models to understand the underlying mechanisms, causes and potential treatments. The use of systematic reviews (SRs) can, in principle, provide a powerful means to synthesise this evidence-base; however, the reporting quality of previous SRs in preclinical animal research has been found lacking (Hunniford et al., 2021). In the current study, Wilson et al. (2023) will undertook a review of systematic reviews to assess the characteristics and reporting quality of SRs that, in turn, synthesise research in genetically-modified animals to model NDCs. In particular, the authors extracted key features of reviews (including, among others, the aim and primary research questions, relevant animal model, and number of studies in the SR), in addition to quality indicators such as risk of bias and completeness of reporting. In doing so, the authors aimed to enhance guidance on the conduct and reporting of systematic reviews in this area.
 
Of twelve publications that met the preregistered search criteria, the completeness and quality of reporting was variable. Among the better reported characteristics were search strategies (9 of 12 articles), reporting of funding sources (10 of 12 articles) and use of animal data (11 of 12 articles). In contrast, only two articles reported whether the study protocol was preregistered, only three articles reported methods for assessing risk of bias, and just one included methods to analyse publication bias. In addition, the authors identified 19 review registrations via PROSPERO, most of which remained unpublished after their anticipated end dates. Overall, the results highlight the importance of adherence to reporting guidelines for increasing the transparency and reproducibility of SRs in this field.
 
The Stage 2 manuscript was evaluated over one round of in-depth review. Based on detailed responses by the authors, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
 
URL to the preregistered Stage 1 protocol: https://osf.io/952qk
 
Level of bias control achieved: Level 4. At least some of the data/evidence that was used to answer the research question already existed prior to IPA and was accessible in principle to the authors, but the authors certify that they did not access any part of that data/evidence prior to IPA.
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Hunniford V. T., Montroy J., Fergusson D. A., Avey M. T., Wever K. E., McCann S. K., Foster M., Fox G., Lafreniere M., Ghaly M., Mannell S., Godwinska K., Gentles A., Selim S., MacNeil J., Sikora L., Sena E. S., Page M. J., Macleod M., Moher D., & Lalu M. M. (2021). Epidemiology and reporting characteristics of preclinical systematic reviews. PLOS Biology, 19:e3001177. https://doi.org/10.1371/journal.pbio.3001177
 
2. Wilson, E., Currie, G., Macleod, M., Kind, P. & Sena, E. S. (2023). Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting quality [Stage 2]. Acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/s5xd4
Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting qualityEmma Wilson, Gillian Currie, Malcolm Macleod, Peter Kind, and Emily S Sena<p><strong>Objective</strong><br>Using genetically-modified animals to model neurodevelopmental conditions (NDCs) helps better our understanding of biology underlying these conditions. Animal research has unique characteristics not shared with cli...Medical SciencesChris Chambers2023-11-22 10:26:44 View
28 Sep 2023
STAGE 1

Investigating the barriers and enablers to data sharing behaviours: A qualitative Registered Report

Capability, Opportunity, and Motivation in Data Sharing Behaviour

Recommended by ORCID_LOGO based on reviews by Moin Syed, Peter Branney and Libby Bishop
In the past two decades, most academic fields have witnessed an open science revolution that has led to significant increases in open access publishing, reproducibility efforts, and scientific transparency in general (e.g., Spellman et al. 2018). One of the key areas in this ongoing change is data sharing. Although some evidence already points at progress in data sharing practices, many new datasets remain unshared (see Tedersoo et al. 2021).
 
In the present registered report, Henderson et al. (2023) empirically explore the factors that either hinder or facilitate data sharing in the UK. By means of semi-structured interviews, the team will chart researchers’ experiences of sharing and non-sharing. Thematic template analysis will be applied to organise the data into a hierarchical map of capabilities, opportunities, and motivations in a theoretical domains framework (COM-B-TDF). The research plan itself meets the highest open science standards and reflects on the authors own positions, from which the current qualitative interview data sharing efforts will be made.
 
The Stage 1 manuscript was reviewed over three rounds by three experts with familiary of the UK cultural context and specializations in open science practices, qualitative research, and data infrastructures. Based on careful revisions and detailed responses to the reviewers’ comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.
 
URL to the preregistered Stage 1 protocol: https://osf.io/2gm5s (under temporary private embargo)
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.  
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Henderson, E., Marcu, A., Atkins, L. & Farran, E.K. (2023). Investigating the barriers and enablers to data sharing behaviours: A qualitative Registered Report. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/2gm5s
 
2. Spellman, B. A., Gilbert, E. A. & Corker, K. S. (2018). Open Science. Stevens' Handbook of Experimental Psychology and Cognitive Neuroscience, 5, 1-47. https://doi.org/10.1002/9781119170174.epcn519
 
3. Tedersoo, L., Küngas, R., Oras, E., Köster, K., Eenmaa, H., Leijen, Ä., ... & Sepp, T. (2021). Data sharing practices and data availability upon request differ across scientific disciplines. Scientific data, 8, 192. https://doi.org/10.1038/s41597-021-00981-0
Investigating the barriers and enablers to data sharing behaviours: A qualitative Registered ReportEmma L Henderson, Afrodita Marcu, Lou Atkins, Emily K Farran<p>Data sharing describes the process of making research data available for reuse. The availability of research data is the basis of transparent, effective research systems that democratise access to knowledge and advance discovery. Despite a broa...Social sciencesVeli-Matti Karhulahti2023-05-11 19:18:48 View
24 Apr 2024
STAGE 1

Synaesthesia as a Model for Assessing Individual Differences in Visual Perception and Memory Performance

What can synaesthesia tell us about links between perception and memory?

Recommended by ORCID_LOGO based on reviews by Janina Neufeld, David Brang and Tessa van Leeuwen
What is the relationship between perception and memory? Although these topics are typically investigated separately, there is evidence that these cognitive processes may be related: for example, individuals with synaesthesia may experience both enhancements in visual acuity and visual memory; and individuals with amnesia may also show deficits in visual perceptual processing. However, comprehensive evidence for the relationship between perception and different forms of memory (both short-term and long-term) is currently lacking.
 
In this Stage 1 manuscript, Whelan et al. (2024) seek to elucidate this relationship by investigating individual differences in perception and memory in a general population sample (i.e., in synaesthetes, non-synaesthetic relatives, and controls). There are two accounts that may explain enhanced perception and memory in synaesthesia: a ‘dual-coding’ account, which suggests that the extra perceptual information often experienced in synaesthesia (e.g., seeing colors for different letters of the alphabet) may contribute to encoding richer information in sensory memory; and an ‘enhanced processing’ account, which posits that enhanced perception and memory in synaesthesia may be due to genetic or environmental factors not directly related to synaesthetic experiences. In the former case, synaesthetes should perform more similarly to each other than to their non-synaesthetic relatives; in the latter case, non-synaesthetic relatives of synaesthetes should show similar perceptual and memory benefits. The current study should therefore find evidence in favor of one of these accounts over the other. In addition to this, the authors will generate multidimensional cognitive profiles of synaesthetes and their relatives, compared to non-synaethetes, including perception, memory, mental imagery and cognitive styles. 
 
The Stage 1 submission was evaluated by the recommender and two expert reviewers. Following revisions, the recommender judged that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/6h8dx (under temporary private embargo)
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Whelan, E., Sachdeva, C., Ovalle-Fresa, R., Rothen R., & Ward, J. (2024). Synaesthesia as a Model for Assessing Individual Differences in Visual Perception and Memory Performance. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/6h8dx
Synaesthesia as a Model for Assessing Individual Differences in Visual Perception and Memory PerformanceEmily Whelan, Chhavi Sachdeva, Rebecca Ovalle-Fresa, Nicolas Rothen and Jamie Ward<p>In this study, the cognitive profile of synaesthesia (a perceptual condition in which primary experiences, such as perceiving digits or words, elicit extra secondary sensations) is used as a model system to assess visual perceptual abilities an...Social sciencesReshanne Reeder2023-11-07 13:02:39 View
06 Feb 2025
STAGE 1

Disentangling the Influences of Curiosity and Active Exploration on Cognitive Map Formation

Investigating influences of curiosity and active exploration on spatial memory

Recommended by ORCID_LOGO based on reviews by Alexandr Ten and 2 anonymous reviewers
A growing body of research suggests that feelings of curiosity are associated with better memory for new information. However, while curiosity has been broadly defined as an instrinsic drive to obtain information, much of this existing work has focused on learning of trivia facts or factual information, settings where people have relatively little freedom to actively explore aspects of the environment that generate those feelings of curiosity. In this Stage 1 manuscript, O'Donoghue, Cen, and Gruber (2025) propose to conduct an experiment to examine whether feelings of curiosity promote the formation of cognitive maps when exploring novel spatial environments. Participants will encounter a series of virtual rooms for which they report their level of curiosity before exploring each room. The experiment will compare groups of participants who can actively explore for themselves vs. passive observers of the same exploration patterns. The proposed analyses will examine whether anticipatory curiosity leads to better memory for the spatial environments for both active or passive participants, or if benefits to memory are mediated by active participants' ability to act of their feelings of curiosity through their exploration of the environment. The findings of the study will provide new insight into the mechanisms through which anticipatory curiosity enhances memory.
 
The Stage 1 submission was evaluated by three expert reviewers. After three rounds of revision, the recommender determined that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/86r3x
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. O'Donoghue, E. M., Cen, D., & Gruber, M. (2025). Disentangling the Influences of Curiosity and Active Exploration on Cognitive Map Formation. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/86r3x
Disentangling the Influences of Curiosity and Active Exploration on Cognitive Map FormationEllen M. O'Donoghue, Danlu Cen, Matthias J. Gruber<p>Curiosity has long been assumed to promote exploration, and in turn, to support cognitive map formation. However, little research has directly investigated these claims. Recently, Cen et al. (2024) demonstrated that when participants feel more ...Social sciencesDouglas Markant2024-06-28 10:30:38 View
09 Sep 2024
STAGE 1

The origin of symbolic numerical knowledge in early development – an fNIRS Registered Report

An fNIRS test of the neural correlates of the Cardinality Principle in typically-developing children

Recommended by ORCID_LOGO based on reviews by Ed Hubbard and 1 anonymous reviewer
The cardinality principle (CP) is a key concept in numerical cognition, which children typically acquire by the age of five. This is the understanding that each number in a counted sequence refers to a specific set of items, and that the final number represents the total size of the set. Here, Ivanova and colleagues (2024) propose an experiment to study the changes in neural activity that accompany the acquisition of this concept, focusing on activity within the parietal lobes as measured by functional near-infrared spectroscopy (fNIRS).
 
Typically-developing children aged from 2 years 9 months to 4 years 9 months will be assessed for their ability to give a specific number of balls from a pile: those who can give five or more correctly will be classified as CP-knowers, and those who can only give lower set sizes will be classified as subset-knowers. All children will then perform an auditory number word adaptation task while undergoing fNIRS. The adaptation task involves hearing the number word ‘two’ repeated, interspersed with deviant number words (‘four’ or ‘eight’) or a non-number word (‘rin’). The experimental hypotheses are that left parietal activations and bilateral parietal functional connectivity will be differentially greater for number than non-number deviants amongst CP-knowers than amongst subset-knowers. Each hypothesis will be tested by sequential Bayes factor analysis, with a minimum of 25 and a maximum of 46 participants per group, providing high sensitivity to detect a smallest effect size of d = .35. This study aims to provide insights into the neural underpinnings of the CP, informing theoretical models of symbolic knowledge acquisition.

The study plan was refined over four rounds of review, with input from two external reviewers, after which the recommender judged that the Stage 1 manuscript met the criteria for in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/gzpk5

Level of bias control achieved: Level 4. At least some of the data/evidence that will be used to answer the research question already exists and is accessible in principle to the authors (e.g. residing in a public database or with a colleague) but the authors certify that they have not yet accessed any part of that data/evidence.
 
List of eligible PCI RR-friendly Journals:
 
 
References
 
Ivanova, E., Joanisse, M., Ansari, D., & Soltanlou, M. (2024). The origin of symbolic numerical knowledge in early development – an fNIRS Registered Report. In principle acceptance of Version 7 by Peer Community in Registered Reports. https://osf.io/gzpk5
The origin of symbolic numerical knowledge in early development – an fNIRS Registered ReportElizaveta Ivanova, Marc Joanisse, Daniel Ansari, Mojtaba Soltanlou<p>The ability to understand that each number word in the count sequence refers to a specific set of items (e.g., ‘two’ means ‘two things’) is a milestone in cognitive development. When children reach this milestone, they are said to understand th...Social sciencesRobert McIntosh2023-03-14 17:25:27 View
15 Jan 2024
STAGE 1

Neurophysiological correlates of plasticity induced by paired associative stimulation (PAS) targeting the motor cortex: a TMS-EEG registered report

Can TMS-evoked potentials act as biomarkers of long-term potentiation or long-term depression induced by paired associative stimulation?

Recommended by ORCID_LOGO based on reviews by Domenica Veniero, Lindsay Oberman and 1 anonymous reviewer
What are the neurophysiological correlates of paired associative stimulation (PAS) in inducing plastic changes in human motor cortex (M1)? Here, Arrigoni and colleagues (2024) will apply transcranial magnetic stimulation (TMS) to left M1 paired with electrical stimulation of the right median nerve at an ISI of 25 ms or 10 ms to induce long-term potentiation (LTP) or long-term depression (LTD), respectively. Arrigoni and colleagues (2024) will determine if these stimulation pairings effect cortical excitability using motor-evoked potentials (MEPs) and TMS-evoked potentials (TEPs). Specifically, they hypothesize PASLTP will increase the peak-to-peak amplitude of MEPs, whereas PASLTD will decrease the amplitude, replicating previous work. They will then extend these previous findings by examining TEPs. The authors anticipate modulation of the P30 and P60, which are TEPs thought to reflect local cortical excitability. They plan to account for the MEP reafference which may also mediate the P60 amplitude by stimulating at sub- and supra- motor threshold. Further, they hypothesize an increase of the N100, a marker of inhibitory processing mediated by GABA, by PASLTD. Finally, the authors will also examine the impact of cortical excitability over time to determine the duration of the PAS effects.   
 
This detailed examination of TEPs following PAS stimulation will determine which TEPs could be used as biomarkers with the induction of LTP and LTD through stimulation. The authors have built in an MEP replication for the PAS stimulation, supporting previous literature and acting as a positive control.  
 
The Stage 1 manuscript was evaluated by three expert reviewers across two rounds. Following in-depth review and responses from the authors, the recommender determined that Stage 1 criteria was met and awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/detjc (under temporary private embargo)
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:
 

References
 
1. Arrigoni, E., Bolognini, N., Pisoni, A. & Guidali, G. (2024). Neurophysiological correlates of plasticity induced by paired associative stimulation (PAS) targeting the motor cortex: a TMS-EEG registered report. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/detjc
Neurophysiological correlates of plasticity induced by paired associative stimulation (PAS) targeting the motor cortex: a TMS-EEG registered reportEleonora Arrigoni, Nadia Bolognini, Alberto Pisoni, Giacomo Guidali<p>Paired associative stimulation (PAS) can induce long-term potentiation (LTP) and long-term depression (LTD) in the human motor system by applying transcranial magnetic stimulation (TMS) pulses on the primary motor cortex (M1) paired with electr...Life SciencesGrace Edwards2023-07-22 10:25:21 View
25 Oct 2024
STAGE 1

They look virtually the same: extraretinal representation of symmetry in virtual reality

How does virtual reality impact the processing of extraretinal symmetry?

Recommended by ORCID_LOGO based on reviews by Daniel Baker, Felix Klotzsche and 1 anonymous reviewer
​Karakashevska and colleagues (2024) aim to examine the extraretinal representation of visual symmetry presented in a virtual reality environment. Previous research had demonstrated that individuals can detect symmetry when the symmetry is represented on a perspective plane, slanted away from the viewer. In electroencephalography (EEG), perceived symmetry is marked by an Event Related Potential (ERP) called a Sustained Posterior Negativity (SPN). When symmetry is presented on a perspective plane in comparison to front-on (frontoparallel), the SPN is reduced, termed the perspective cost. Here, Karakashevska et al., (2024) will determine if presenting symmetry on a perspective plane in a virtual reality (VR) environment will reduce the perspective cost with the addition of 3D depth cues. Specifically, participants will be requested to detect symmetry or luminance of a stimulus presented in a VR environment whilst wearing an EEG. The authors hypothesize that no perspective cost will be identified between symmetry presented on a frontoparallel plane versus symmetry on a perspective plane. Furthermore, the authors will examine the impact of task within the virtual environment on symmetry processing. They hypothesize that a task focused on the regularity of the stimuli will result in a larger amplitude of the SPN than a luminance task. This design enables the authors to pinpoint immersive environments as providing cues critical in overcoming perspective cost.
 
The Stage 1 manuscript was evaluated by two expert reviewers across three rounds. Following in-depth review and responses from the authors, the recommender has determined that Stage 1 criteria was met and has awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/7pnxu
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:
 
References
 
Karakashevska, E., Batterley, M. & Makin, A. D. J. (2024). They look virtually the same: extraretinal representation of symmetry in virtual reality. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/7pnxu
They look virtually the same: extraretinal representation of symmetry in virtual realityElena Karakashevska, Michael Batterley and Alexis D.J. Makin <p>The brain must identify objects from different viewpoints that change the retinal image. This study will determine the conditions under which the brain spends computational resources to construct view-invariant, extraretinal representations in ...Life SciencesGrace Edwards Felix Klotzsche2024-05-23 20:13:42 View
18 Oct 2023
STAGE 1

Putting things into perspective: Which visual cues facilitate automatic extraretinal symmetry representation?

Understanding how visual cues influence extraretinal representation of planar symmetry

Recommended by ORCID_LOGO and ORCID_LOGO based on reviews by Tadamasa Sawada, Guillaume Rousselet, Benoit Cottereau and Deborah Apthorp
Visual symmetry is critical to our interaction with our environment so that when detected, symmetry automatically produces a neural marker in the form of an Event Related Potential (ERP) called Sustained Posterior Negativity (SPN). However, when symmetry is presented to the visual system slanted away from the viewer, there is a reduction in SPN, termed a perspective cost. 
 
Considering ​objects are rarely presented front-on (or frontoparallel) in our natural environment, Karakashevska et al., (2023) plan to examine the extent of the perspective cost with the addition of visual cues to facilitate extraretinal representation of the visual symmetry. The authors will record electroencephalography (EEG) from 120 participants while they perform a luminance task on symmetrical and asymmetrical stimuli. The authors hypothesize perspective cost will be reduced by three perspective cues: 1) monocular viewing, when cue conflict caused by binocular viewing is eliminated, 2) a static frame surrounding the symmetrical stimulus, adding a depth cue, and 3) a moving frame, assisting 3D perception prior to the symmetry onset. If the SPN is equivalent during frontoparallel and slanted presentation in a cue condition, the authors will conclude extraretinal representation can be automatic when sufficient visual cues are available. The proposed experiment is powered to detect a relatively small difference between perspective cue conditions. This will solidify fundamental research on visual symmetry processing and will further our understanding of object perception and recognition. 
 
The Stage 1 manuscript was evaluated over three rounds by four expert reviewers. Following in-depth review and responses from the authors, the recommenders have determined that Stage 1 criteria was met and have awarded in-principle acceptance (IPA). 
​​​​
URL to the preregistered Stage 1 protocol: https://osf.io/yzsq5
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI-RR-friendly journals:
 
 
References
 
1. Karakashevska, E., Bertamini, M. & Makin, A. D. J. (2023). Putting things into perspective: Which visual cues facilitate automatic extraretinal symmetry representation? [Stage 1 Registered Report]. In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/yzsq5
Putting things into perspective: Which visual cues facilitate automatic extraretinal symmetry representation?Elena Karakashevska, Marco Bertamini and Alexis D.J. Makin <p>A challenge for the visual brain is to identify objects from a range of different viewpoints. This study will determine the conditions under which the brain spends computational resources to achieve view-invariance. We focus on view-invariant r...Life SciencesGrace Edwards2023-04-17 21:52:26 View
13 Nov 2024
STAGE 2
(Go to stage 1)

Putting things into perspective: Which visual cues facilitate automatic extraretinal symmetry representation?

Understanding how visual cues influence extraretinal representation of planar symmetry

Recommended by ORCID_LOGO and ORCID_LOGO based on reviews by Guillaume Rousselet and 2 anonymous reviewers
Visual symmetry is critical to our interaction with our environment so that when detected, symmetry automatically produces a neural marker in the form of an Event Related Potential (ERP) called Sustained Posterior Negativity (SPN). However, when symmetry is presented to the visual system slanted away from the viewer, there is a reduction in SPN, termed a perspective cost. 
 
Considering ​objects are rarely presented front-on (or frontoparallel) in our natural environment, Karakashevska et al., (2023) examined the extent of the perspective cost with the addition of visual cues to facilitate extraretinal representation of the visual symmetry. The authors recorded electroencephalography (EEG) from 120 participants while they performed a luminance task on symmetrical and asymmetrical stimuli. The authors hypothesized that perspective cost would be reduced by three perspective cues: 1) monocular viewing, eliminating binocular cue conflict, 2) a static frame surrounding the symmetrical stimulus, adding a depth cue, and 3) a moving frame, providing a structure-from-motion 3D cue, prior to the symmetry onset. If the SPN was equivalent during frontoparallel and slanted presentation in a cue condition, the authors would have concluded extraretinal representation can be automatic when sufficient visual cues are available. The experiment was powered to detect a relatively small difference between perspective cue conditions.
 
The authors found that there was no impact of different visual cues on the perspective cost, as measured using the SPN. Perspective cost was consistent across all conditions, contrary to the pre-registered hypotheses. Karakashevska and colleagues conclude that the three perceptual cues tested in their design do not reduce perspective cost. The study prompts future research into the nature of the extraretinal representations of planar symmetry.  
 
The Stage 2 manuscript was evaluated over four rounds by three expert reviewers. Two of our reviewers reviewed the Stage 1 manuscript, and one new reviewer. Following in-depth review and responses from the authors, the recommenders determined that the Stage 2 criteria were met and awarded a positive recommendation.
 
URL to the preregistered Stage 1 protocol: https://osf.io/yzsq5
 
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA.
 
List of eligible PCI-RR-friendly journals:
 

References
  
1. Karakashevska, E., Bertamini, M. & Makin, A. D. J. (2024). Putting things into perspective: Which visual cues facilitate automatic extraretinal symmetry representation? [Stage 2]. Acceptance of Version 5 by Peer Community in Registered Reports. https://doi.org/10.31234/osf.io/z9c28
Putting things into perspective: Which visual cues facilitate automatic extraretinal symmetry representation?Elena Karakashevska, Marco Bertamini and Alexis D.J. Makin <p>Abstract</p> <p>Introduction: Objects often project different images when viewed from different locations. Our visual system can correct for perspective distortion and identify objects from different viewpoints that change the retinal image. T...Life SciencesGrace Edwards2024-06-03 21:00:08 View
27 Jun 2023
STAGE 1

Functional MRI brain state occupancy in the presence of cerebral small vessel disease -- pre-registration for a replication analysis of the Hamburg City Health Study

Testing the replicability of dynamic functional connectivity correlates of cerebral small vessel disease in the Hamburg City Health Study

Recommended by ORCID_LOGO based on reviews by Olivia Hamilton and 1 anonymous reviewer
A recent study has reported that the extent of cerebral small vessel disease (cSVD) shows associations with dynamic functional connectivity measures obtained from resting state functional MRI scans (Schlemm et al, 2022). Specifically, when the functional scan was parsed into time spent in discrete brain states, the proportion of time spent in the two most-occupied states was negatively related to a structural indicator of cSVD (volume of white matter hyperintensities of presumed vascular origin). This measure of 'fractional occupancy' was also associated with cognitive impairment as indicated by longer time to complete part B of the Trail Making Test. These findings were based on the analysis of data from 988 participants in the Hamburg City Health Study (HCHS).
 
In the present Registered Report, Schlemm (2023) will test whether these associations can be replicated in an independent sample of participants from the HCHS, not included in the earlier analysis (projected N for new analysis ~1500). In addition to the two main hypothesis tests, an exploratory multiverse analysis will be reported, systematically varying some key parameters of the MRI processing pipeline to provide further information about the robustness of the outcome of the primary hypothesis test. 
 
The Stage 1 plan was refined over two rounds of review by two relevant experts, with additional input from the recommender on the specification of the registered plan. Both reviewers are satisfied that the plan constitutes an appropriate approach to this question, and on the basis of their comments and his own evaluation, the recommender judged that the Stage 1 report meets the criteria for in-principle acceptance.
 
URL to the preregistered Stage 1 protocol: https://osf.io/9yhzc
 
Level of bias control achieved: Level 2. At least some data/evidence that will be used to answer the research question has been accessed and partially observed by the authors, but the authors certify that they have not yet observed the key variables within the data that will be used to answer the research question AND they have taken additional steps to maximise bias control and rigour.
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Schlemm, E., Frey, B. M., Mayer, C., Petersen, M., Fiehler, J., Hanning, U., Kühn, S., Twerenbold, R., Gallinat, J., Gerloff, C., Thomalla, G. & Cheng, B. (2022). Equalization of brain state occupancy accompanies cognitive impairment in cerebral small vessel disease. Biological Psychiatry, 92, 592-602. https://doi.org/10.1016/j.biopsych.2022.03.019
 
2. Schlemm, E. (2023). Functional MRI brain state occupancy in the presence of cerebral small vessel disease – pre-registration for a replication analysis of the Hamburg City Health Study. In principle acceptance of Version 1.5 by Peer Community in Registered Reports. https://osf.io/9yhzc
Functional MRI brain state occupancy in the presence of cerebral small vessel disease -- pre-registration for a replication analysis of the Hamburg City Health StudyEckhard Schlemm<p>Objective: To replicate recent findings about the association between the extent of cerebral small vessel disease (cSVD), functional brain network dedifferentiation and cognitive impairment.</p> <p>Methods: We will analyze demographic, imaging...Life Sciences, Medical SciencesRobert McIntosh2022-11-19 14:21:28 View