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Latest recommendations
| Id | Title * | Authors * | Abstract * | Picture | Thematic fields * ▲ | Recommender | Reviewers | Submission date | |
|---|---|---|---|---|---|---|---|---|---|
14 Aug 2023
STAGE 1
Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception?Understanding oscillatory correlates of pain expectationRecommended by Gemma Learmonth based on reviews by Zoltan Dienes, Chris Chambers and Markus Ploner
Recent studies using an EEG frequency tagging approach have reported modulations of alpha, beta and theta bands at the stimulation frequency during nociceptive/painful thermal stimulation compared to non-nociceptive/non-painful vibrotactile stimulation. Prior expectations of the intensity of upcoming painful stimuli are known to strongly modulate the subjective experience of those stimuli. Thus, modulating the expectation of pain should result in a change in the modulation of oscillations if these factors are indeed linked.
In this study, Leu, Glineur and Liberati will modulate expectations of pain (low or high intensity) prior to delivering thermal cutaneous stimulation (low, medium or high intensity). They will record how intense participants expect the pain to be, and how intense they felt it to be, as well as record EEG to assess oscillatory differences across the expectation and intensity conditions.
The Stage 1 manuscript was reviewed over 5 rounds by 3 reviewers. Based on detailed responses to the reviewers’ comments and edits to the Stage 1 report, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.
URL to the preregistered Stage 1 protocol: https://osf.io/y6fb8
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals: References
1. Leu, C., Glineur, E. & Liberati, G. (2023). Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception? In principle acceptance of Version 5 by Peer Community in Registered Reports. https://osf.io/y6fb8 | Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception? | Chiara Leu, Esther Glineur, Giulia Liberati | <p>A promising stream of investigations is targeting ongoing neural oscillations and whether their modulation could be relevant for the perception of pain. Specifically, sustained periodic thermonociceptive stimuli have been shown to modulate ongo... | Medical Sciences | Gemma Learmonth | Zoltan Dienes | 2023-03-15 14:41:03 | ||
Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting qualityEvidence for mixed quality of systematic reviews in preclinical animal studies of neurodevelopmental conditionsRecommended by Chris Chambers based on reviews by Marietta Papadatou-Pastou
Single gene alterations have been estimated to account for nearly half of neurodevelopmental conditions (NDCs), providing a crucial opportunity for animal models to understand the underlying mechanisms, causes and potential treatments. The use of systematic reviews (SRs) can, in principle, provide a powerful means to synthesise this evidence-base; however, the reporting quality of previous SRs in preclinical animal research has been found lacking (Hunniford et al., 2021). In the current study, Wilson et al. (2023) will undertook a review of systematic reviews to assess the characteristics and reporting quality of SRs that, in turn, synthesise research in genetically-modified animals to model NDCs. In particular, the authors extracted key features of reviews (including, among others, the aim and primary research questions, relevant animal model, and number of studies in the SR), in addition to quality indicators such as risk of bias and completeness of reporting. In doing so, the authors aimed to enhance guidance on the conduct and reporting of systematic reviews in this area.
Of twelve publications that met the preregistered search criteria, the completeness and quality of reporting was variable. Among the better reported characteristics were search strategies (9 of 12 articles), reporting of funding sources (10 of 12 articles) and use of animal data (11 of 12 articles). In contrast, only two articles reported whether the study protocol was preregistered, only three articles reported methods for assessing risk of bias, and just one included methods to analyse publication bias. In addition, the authors identified 19 review registrations via PROSPERO, most of which remained unpublished after their anticipated end dates. Overall, the results highlight the importance of adherence to reporting guidelines for increasing the transparency and reproducibility of SRs in this field.
The Stage 2 manuscript was evaluated over one round of in-depth review. Based on detailed responses by the authors, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/952qk Level of bias control achieved: Level 4. At least some of the data/evidence that was used to answer the research question already existed prior to IPA and was accessible in principle to the authors, but the authors certify that they did not access any part of that data/evidence prior to IPA.
List of eligible PCI RR-friendly journals: References
1. Hunniford V. T., Montroy J., Fergusson D. A., Avey M. T., Wever K. E., McCann S. K., Foster M., Fox G., Lafreniere M., Ghaly M., Mannell S., Godwinska K., Gentles A., Selim S., MacNeil J., Sikora L., Sena E. S., Page M. J., Macleod M., Moher D., & Lalu M. M. (2021). Epidemiology and reporting characteristics of preclinical systematic reviews. PLOS Biology, 19:e3001177. https://doi.org/10.1371/journal.pbio.3001177
2. Wilson, E., Currie, G., Macleod, M., Kind, P. & Sena, E. S. (2023). Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting quality [Stage 2]. Acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/s5xd4
| Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting quality | Emma Wilson, Gillian Currie, Malcolm Macleod, Peter Kind, and Emily S Sena | <p><strong>Objective</strong><br>Using genetically-modified animals to model neurodevelopmental conditions (NDCs) helps better our understanding of biology underlying these conditions. Animal research has unique characteristics not shared with cli... | Medical Sciences | Chris Chambers | 2023-11-22 10:26:44 | |||
24 Sep 2021
STAGE 1
Phenomenological Strands for Gaming Disorder and Esports Play: A Qualitative Registered ReportHow does the phenomenology of "gaming disorder" differ from intensive but non-pathological videogame play?Recommended by Chris Chambers based on reviews by Malte Elson, Peter Branney and Michelle Carras
In this Stage 1 Registered Report, Karhulahti and colleagues (2021) propose a qualitative, interview-based study of videogame play, with the central aim to understand key phenomological differences between gaming behaviour that is associated with vs. without health problems. This question is particularly important given the recent inclusion of "gaming disorder" in the WHO's International Statistical Classification of Diseases and Related Health Problems (ICD). In recent years, the validity of "gaming disorder" as an identifiable mental illness has been controversial (e.g. Van Rooij et al, 2018), as has the debate concerning purported harms or benefits of gaming for mental health. This Stage 1 manuscript describes a rigorous qualitative investigation that should provide new insights on this question, and will also include a longitudinal component to examine changes in phenomonology over time, as well as an examination of the extent to which the phenomonology of gaming is reflected in the experiences of medical experts such as doctors, nurses, and therapists who have worked with gaming-related health problems. More broadly, the manuscript breaks new ground for Registered Reports, being one of the first to focus on qualitative methods, while also making use of the Programmatic submission track in which the approved Stage 1 manuscript is intended to produce two Stage 2 manuscripts focusing on different elements of the project. Three expert reviewers with a variety of field-specialist and qualitative methodological expertise assessed the Stage 1 manuscript over two rounds of in-depth review. Following revision, the reviewers and recommender agreed that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA). URL to the preregistered Stage 1 protocol: https://osf.io/a2rwg Level of bias control achieved: Level 4. At least some of the data/evidence that will be used to answer the research question already exists AND is accessible in principle to the authors (e.g. residing in a public database or with a colleague), BUT the authors certify that they have not yet accessed any part of that data/evidence. List of eligible PCI RR-friendly journals: References
| Phenomenological Strands for Gaming Disorder and Esports Play: A Qualitative Registered Report | Veli-Matti Karhulahti, Miia Siutila, Jukka Vahlo, Raine Koskimaa | <p style="text-align: justify;">The recent inclusion of gaming disorder in the ICD-11 as a mental disorder has further increased the importance of researching the health spectrum related to gaming. A critical area in this regard is the lack of cla... | | Medical Sciences, Social sciences | Chris Chambers | 2021-06-16 20:22:24 | ||
17 Nov 2022
STAGE 1
Removing barriers to plant-based diets: assisting doctors with vegan patientsStage 1 acceptance (IPA)Recommended by Zoltan Dienes based on reviews by Joshua Tasoff, Bence Palfi and Alaa Aldoh
Thank you for your careful response to the points of myself and the reviewers. I am now happy to award in principle acceptance (IPA). As requested, your submission is being awarded a private Stage 1 acceptance, which will not appear yet on the PCI RR website. Your Stage 1 manuscript has also been registered under the requested 4-year private embargo on the OSF (link below). URL to the preregistered Stage 1 protocol: https://osf.io/fc9gp Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals: | Removing barriers to plant-based diets: assisting doctors with vegan patients | Romain Espinosa, Thibaut Arpinon, Paco Maginot, Sébastien Demange, and Florimond Peureux | <div style="text-align: justify;">Shifting to plant-based diets can alleviate many of the externalities associated with the current food system. Spontaneous shifts in diet are often hindered by consumers’ imperfect knowledge about the health risks... | Medical Sciences, Social sciences | Zoltan Dienes | 2021-08-16 16:50:43 | |||
17 Jan 2022
STAGE 1
Identifying Gaming Disorders by Ontology: A Nationally Representative Registered ReportDo different screening instruments for ‘gaming disorder’ measure the same or different construct(s)?Recommended by Charlotte Pennington based on reviews by Daniel Dunleavy, Linda Kaye, David Ellis and 1 anonymous reviewer
There is considerable debate regarding the relationship between excessive gaming and mental health problems. Whilst the diagnostic classification of “gaming disorder” has now been included in the WHO’s International Classification of Diseases (ICD-11), the APA decided not to include this diagnosis in their Diagnostic and Statistical Manual of Mental Disorders (DSM-5) because the literature “suffers from a lack of a standard definition from which to derive prevalence data” (APA 2013, p. 796). Furthermore, screening instruments that aim to provide diagnostic classifications derive from different ontologies and it is not known whether they identify equivalent prevalence rates of ‘gaming disorder’ or even the same individuals. In this Stage 1 Registered Report, Karhulahti et al. (2022) aim to assess how screening instruments that derive from different ontologies differ in identifying associated problem groups. A nationally representative sample of 8000 Finnish individuals will complete four screening measures to assess the degree of overlap between identified prevalence (how many?), who they identify (what characteristics?) and the health of their identified groups (how healthy?). If these four ontologically diverse instruments operate similarly, this will support the notion of a single “gaming disorder” construct. If, however, the instruments operate differently, this will suggest that efforts should be directed toward assessing the clinical (ir)relevance of multiple constructs. This rigorous study will therefore have important implications for the conceptualisation and measurement of “gaming disorder”, contributing to the debate around the mixed findings of gaming-related health problems. Four expert reviewers with field expertise assessed the Stage 1 manuscript over three rounds of in-depth review. Based on detailed and informed responses to the reviewers' comments, the recommender decided that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA). URL to the preregistered Stage 1 protocol: https://osf.io/usj5b Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References
| Identifying Gaming Disorders by Ontology: A Nationally Representative Registered Report | Veli-Matti Karhulahti, Jukka Vahlo, Marcel Martončik, Matti Munukka, Raine Koskimaa, Mikaela von Bonsdorff | <p style="text-align: justify;">Gaming-related health problems have been researched since the 1980s with numerous different “ontologies” as reference systems, from self-assessed “game addiction” to “pathological gambling” (in the DSM-IV), “interne... | | Medical Sciences, Social sciences | Charlotte Pennington | 2021-08-25 23:08:26 | ||
05 Aug 2022
STAGE 1
Through the lens of Developmental Coordination Disorder (DCD): experiences of a late diagnosisDevelopmental Coordination Disorder Diagnosis as Part of Evolving Self-ConceptsRecommended by Veli-Matti Karhulahti based on reviews by Moin Syed, Gill Waters and Catherine Purcell
Although developmental coordination disorder (DCD) is a common neurodevelopmental disorder with an estimated prevalence of up to 6% in children (APA, 2013), many DCD diagnoses are not made before late adulthood. Receiving a neurodevelopmental disorder diagnosis has been found adding to people’s self-concepts, for instance, with autism spectrum disorder (Tan, 2018), but it is not well known if and how such events unfold in late DCD diagnoses. In this Stage 1 Registered Report, Topor et al. (2022) present a careful plan to qualitatively investigate the lived experiences of individuals with a late DCD diagnosis in order to map out the variety of emotional responses to diagnoses and their effects on self-concepts.
Topor et al. (2022) will carry out 10–15 semi-structured interviews with participants who received a DCD diagnosis at the age of 30 or after. They commit to realist epistemology when utilizing thematic analysis; namely, instructions have been preregistered for two separate analysts who will code the transcript data independently. At the same time, the methodology involves reflexive components. The authors have prepared strong positionality statements through which their analyses will be carried out with post-analysis reflections to be written at Stage 2. The coding process will explicitly involve a data analysis log that pursues interpretive transparency. The data and materials will be shared, which adds to the work's value in the context of open qualitative psychology in general. The study will help us better understand the process of receiving (late) DCD diagnoses and, specifically, how the emotional aftermath is potentially related to one’s evolving self-concept. In addition to making a clear contribution to cumulative scientific knowledge, the findings can be useful for professionals working with DCD-diagnosed individuals as well as for the development of related support services. The Registered Report format allowed the research design to be reviewed in three rounds before data collection. Initially, three experts representing developmental psychology and DCD reviewed the Stage 1 manuscript, after which the recommender carried out two iterations with further requested revisions. This was followed by in-principle acceptance. URL to the preregistered Stage 1 protocol: https://osf.io/67h3f
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References
1. APA (2013) Diagnostic and statistical manual of mental disorders, 5th ed, American Psychiatric Association, Washington, DC. 2. Tan, C. D. (2018). “I'm a normal autistic person, not an abnormal neurotypical”: Autism Spectrum Disorder diagnosis as biographical illumination.” Social Science & Medicine, 197, 161-167. 3. Topor, M., Armstrong, G., Gentle, J. (2022). Through the lens of Developmental Coordination Disorder (DCD): experiences of a late diagnosis, in principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/67h3f
| Through the lens of Developmental Coordination Disorder (DCD): experiences of a late diagnosis | Marta Topor, Gemma Armstrong, Judith Gentle | <p>A late diagnosis of a lifelong neurodevelopmental condition has been shown to be an important life event with strong emotional consequences and deep personal reflections. Developmental Coordination Disorder (DCD/Dyspraxia) is a common, y... | Medical Sciences, Social sciences | Veli-Matti Karhulahti | 2022-01-11 21:48:18 | |||
Ontological Diversity in Gaming Disorder Measurement: A Nationally Representative Registered ReportDifferent ontologies, different constructs? Instruments for gaming-related health problems identify different groups of people and measure different problemsRecommended by Charlotte Pennington based on reviews by Daniel Dunleavy and David Ellis
Screening instruments that aim to provide diagnostic classifications of gaming-related health problems derive from different ontologies and it is not known whether they identify equivalent prevalence rates of ‘gaming disorder’ or even the same individuals. Underpinned by this, Karhulahti et al. (2022) assessed how screening instruments that derive from different ontologies differ in identifying associated problem groups. A nationally representative sample of 8217 Finnish participants completed four screening measures to assess the degree of overlap between identified prevalence (how many?), who they identify (what characteristics?) and the health of their identified groups (how healthy?).
The results indicate that measures based on the ICD-11, DSM-5, DSM-IV, and self-assessment appear to be associated with lower mental health. However, these measures of gaming-related health problems differed significantly in terms of prevalence and/or overlap, suggesting that they identify different groups of people and that different problems or constructs are being measured by different instruments. These findings are important because they contribute to the rapidly growing literature on the ‘fuzziness’ of constructs and measures relating to technology use. The authors recommend that researchers working with these measures should: (a) define their construct of interest; and (b) evaluate the construct validity of their instruments. Being able to answer these questions will enhance research quality and contribute to strengthened meta-analyses. Importantly, this will prevent hype around gaming-related disorders, allowing researchers to communicate clearly and appropriately without risk of confusing related yet different constructs.
The Stage 2 manuscript was evaluated by two of the reviewers who assessed it at Stage 1. Following revision, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation. To ensure that the manuscript met the requirements of the PCI RR TOP guidelines, prior to this acceptance an email communication was sent to the authors by the recommender to ensure that study data were openly available on a temporary OSF link before the final data archive is full validated by the Finnish Social Sciences Data Archive (FSD). This is noted in the recommended preprint.
URL to the preregistered Stage 1 protocol: https://osf.io/usj5b
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question existed prior to Stage 1 in-principle acceptance.
List of eligible PCI RR-friendly journals:
References
1. Karhulahti V.-M., Vahlo J., Martončik M., Munukka M., Koskimaa R. and Bonsdorff M. (2022). Ontological Diversity in Gaming Disorder Measurement: A Nationally Representative Registered Report. Peer-reviewed and recommended at Stage 2 by Peer Community in Registered Reports https://psyarxiv.com/qytrs
| Ontological Diversity in Gaming Disorder Measurement: A Nationally Representative Registered Report | Veli-Matti Karhulahti, Jukka Vahlo, Marcel Martončik, Matti Munukka, Raine Koskimaa, Mikaela von Bonsdorff | <p>Gaming-related health problems have been researched since the 1980s with numerous different “ontologies” as reference systems, from self-assessed “game addiction” to “pathological gambling” (in the DSM-IV), “internet gaming disorder” (in the 3r... | Medical Sciences, Social sciences | Charlotte Pennington | 2022-05-23 16:14:04 | |||
Phenomenological Strands for Gaming Disorder and Esports Play: A Qualitative Registered ReportThe lived experience of gamers: a comparative qualitative investigation of treatment-seekers and esports playersRecommended by Chris Chambers based on reviews by Malte Elson and Peter Branney
Since 2018, the inclusion of “gaming disorder” in the ICD-11 has been met with a mixture of interest, confusion and controversy (Van Rooij et al, 2018), mirroring broader debates about the effects of gaming on mental health. One of the major gaps in understanding the validity of gaming disorder as an identifiable mental illness is the absence of qualitative studies comparing the lived experience of gamers who seek treatment with esports players who do not report health problems.
Here, Karhulahti et al. (2022) tackle this question in the first of two Stage 2 Registered Reports associated with their previous programmatic Stage 1 submission. Using interpretative phenomenological analysis in gamers and medical experts, they find that treatment-seekers and esports players differ in how gaming is associated with the sense of self, either interfering with the self for treatment-seekers or successfully integrating into the self for esports players. These findings help to identify the key characteristics of problematic and non-problematic gaming and call for more intensive and wide-reaching qualitative research in this area.
Following one round of in-depth review and revision, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/a2rwg
Level of bias control achieved: Level 4. At least some of the data/evidence that was used to answer the research question existed prior to in-principle acceptance(IPA) but the authors certify that they did not access any part of that data/evidence prior to IPA.
List of eligible PCI RR-friendly journals:
References
1. van Rooij AJ, Ferguson CJ, Carras MC, Kardefelt-Winther D, Shi J, Aarseth E, Bean AM, Bergmark KH, Brus A, Coulson M, Deleuze J, Dullur P, Dunkels E, Edman J, Elson M, Etchells PJ, Fiskaali A, Granic I, Jansz J, Karlsen F, Kaye LK, Kirsh B, Lieberoth A, Markey P, Mills KL, Nielsen RKL, Orben A, Poulsen A, Prause N, Prax P, Quandt T, Schimmenti A, Starcevic V, Stutman G, Turner NE, Looy J van, Przybylski AK (2018) A weak scientific basis for gaming disorder: Let us err on the side of caution. Journal of Behavioral Addictions, 7, 1–9. https://doi.org/10.1556/2006.7.2018.19
2. Karhulahti V-M, Siutila M, Vahlo J, Koskimaa R (2022) Phenomenological Strands for Gaming Disorder and Esports Play: A Qualitative Registered Report. Stage 2 Registered Report, acceptance of Version 2 by Peer Community in Registered Reports. https://doi.org/10.31234/osf.io/q53jz
| Phenomenological Strands for Gaming Disorder and Esports Play: A Qualitative Registered Report | Veli-Matti Karhulahti, Miia Siutila, Jukka Vahlo, Raine Koskimaa | <p>The recent inclusion of gaming disorder in the ICD-11 as a mental disorder has further increased the importance of researching the health spectrum related to gaming. A critical area in this regard is the lack of clarity concerning the differenc... |  | Medical Sciences, Social sciences | Chris Chambers | 2022-06-11 23:49:03 | ||
Removing barriers to plant-based diets: assisting doctors with vegan patientsInforming doctors of the evidence on plant-based dietsRecommended by Zoltan Dienes based on reviews by Alaa Aldoh, Joshua Tasoff and Bence Palfi
What the best diet is has always been an area of contention. But one thing is clear: Meat is not necessary for health or fitness, and a diet high in plant proteins may well be especially healthy (e.g. Herpich et al., 2022). Further, plant- rather than animal-based diets leave a lower carbon footprint. So what might hold people back from adopting a plant-based diet? One reason is that people may understandably approach their doctor for advice; and the doctor may advise against it, given that many doctors are not well trained in nutrition (Crowley et al., 2019).
Espinosa et al. (2022) conducted a randomised control trial on French general practitioners with 200 doctors given a leaflet and access to an online platform, and 200 controls. The information in the materials concerned the health benefits of plant-based diets, and what nutrients (e.g. B12) may be deficient and what may not be. Attitudes towards and knowledge about plant-based diets was assessed. On a scale of 0-100% expressing whether they would advise for or against (0 = not at all, 100 = absolutely), the intervention shifted attitudes making them more positive about plant based diets by 17 percentage points. However, knowledge of specifically what is worth testing for (e.g. is zinc deficiency more probable or not?) did not change much. The research shows just what can be achieved by a small leaflet (shifting attitudes) and what may require more extensive training (knowledge of relevant medical practice). The Stage 2 manuscript was evaluated over one round of in-depth review. Based on the responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation. URL to the preregistered Stage 1 protocol: https://osf.io/fc9gp Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question existed prior to Stage 1 in-principle acceptance. List of eligible PCI RR-friendly journals: References 1. Crowley, J., Ball, L. & Hiddink, G. J. (2019.) Nutrition in medical education: a systematic review. Lancet Planetary Health. 3, e379–e389. https://doi.org/10.1016/S2542-5196(19)30171-8 2. Herpich, C., Müller-Werdan, U., & Norman, K. (2022). Role of plant-based diets in promoting health and longevity. Maturitas, 165, 47-51. https://doi.org/10.1016/j.maturitas.2022.07.003
3. Espinosa, R., Arpinon, T., Maginot, P., Demange, S. & Peureux, F. (2022). Removing barriers to plant-based diets: assisting doctors with vegan patients, acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/kq6eh?view_only=66eab29c7acb4aebbcec4631cbcb9217
| Removing barriers to plant-based diets: assisting doctors with vegan patients | Romain Espinosa, Thibaut Arpinon, Paco Maginot, Sébastien Demange, and Florimond Peureux | <p>Shifting to plant-based diets can alleviate many of the externalities associated with the current food<br>system. Spontaneous shifts in diet are often hindered by consumers’ imperfect knowledge about the<br>health risks and benefits, which lead... | Medical Sciences, Social sciences | Zoltan Dienes | 2022-08-27 11:01:32 | |||
Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgeryIs childhood adversity associated with a heightened response to opioids?Recommended by Chris Chambers based on reviews by Zoltan Dienes, Yuki Yamada and 1 anonymous reviewer
A convergence of evidence suggests that early life adversity may cause dysfunction in opioid-sensitive reward systems. Childhood adversity is associated with opioid use, potentially by altering reward and motivation networks, and experimental models in animals have found that early life adversity increases and consolidates opioid seeking behaviours. Further, in a recent controlled experiment, Carlyle et al. (2021) found that opioid administration produced stronger positive responses, and weaker negative responses, in adults with a history of childhood abuse and neglect.
In the current study, Carlyle et al. (2023) tested the generalisability of these previous findings in a pre-operative clinical setting. Using partially observed data from an existing cohort study (N=155), the authors asked whether patients with greater experience of childhood trauma in turn exhibit a larger mood boost and express greater subjective pleasure following opioid administration.
In contrast to previous findings, the results did not support the hypotheses that more experiences of childhood adversity would heighten ratings of drug liking and feeling good following opioid administration. Regression analyses instead revealed a statistically significant negative association between childhood adversity and post-opioid liking and no significant relationship with feeling good. The authors suggest that the discrepancy between the current and previous results may be due to stress related to the pre-surgical setting, the brief duration of drug exposure, and the relatively limited levels of high childhood adversity in the study sample. Nevertheless, these findings cast some doubt on the theory that adversity elevates risk of opioid addiction by altering sensitivity to subjectively pleasurable effects.
Following one round of in-depth review, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/7ymts Level of bias control achieved: Level 2. At least some data/evidence that was used to answer the research question had been accessed and partially observed by the authors prior to IPA, but the authors certify that they had not yet observed the key variables within the data that were used to answer the research question AND they took additional steps to maximise bias control and rigour. List of eligible PCI RR-friendly journals:
References
1. Carlyle M., Broomby R., Simpson G., Hannon R., Fawaz L., Mollaahmetoglu O.M., Drain, J., Mostazir, M., & Morgan C. (2021). A randomised, double‐blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine. Addiction Biology, 26(6):e13047. https://doi.org/10.1111/adb.13047
2. Carlyle, M., Kvande, M., Meier, I. M., Trøstheim, M., Buen, K., Jensen, E. N., Ernst, G. & Leknes, S. & Eikemo, M. (2023). Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery, acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/9kt3a?view_only=4238d2ee3d654c4f908a94efea82a027
| Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery | Molly Carlyle1*, Malin Kvande*, Isabell M. Meier, Martin Trøstheim, Kaja Buen, Eira Nordeng Jensen, Gernot Ernst, Siri Leknes, Marie Eikemo (*denotes equal contribution) | <p><strong>Introduction</strong>: Opioid analgesic treatment during surgery entails risk of persistent use. Experiences of childhood adversity have been shown to increase opioid reward in preclinical models, a finding recently extended to healthy ... | Medical Sciences, Social sciences | Chris Chambers | 2023-02-02 08:29:18 |
