In a previous analysis of data from 988 participants in the Hamburg City Health Study (HCHS), Schlemm and colleagues (2022) reported significant associations between the extent of cerebral small vessel disease (cSVD) and dynamic functional connectivity measures from resting state fMRI. Specifically, the volume of white matter hyperintensities of presumed vascular origin, a structural indicator of cSVD, was negatively related to the proportion of time (‘fractional occupancy’) spent in the two most occupied functional brain states. Reduced fractional occupancy was also associated with longer times to complete part B of the Trail Making Test.

 

In the present Registered Report, Ingwersen and colleagues (2023) successfully replicated these associations between structural, functional and cognitive measures in a sample of 1651 HCHS participants not included in the earlier study. An exploratory multiverse analysis found that the associations were generally robust to different brain parcellation and confound regression strategies. These replicable patterns reinforce the idea that cSVD may disrupt the brain’s ability to enter and maintain distinct functional modes, and that these changes in functional dynamics are predictive of cognitive impairment.

 

The Stage 2 manuscript was assessed over one round of in-depth review. The recommender judged that responses to reviewer comments were appropriate, and that the manuscript met the Stage 2 criteria for recommendation.

 

URL to the preregistered Stage 1 protocol: https://osf.io/9yhzc
 
Level of bias control achieved: Level 2. At least some data/evidence that was used to answer the research question had been accessed and partially observed by the authors prior to Stage 1 in-principle acceptance, but the authors certify that they had not yet observed the key variables within the data that were used to answer the research question AND they took additional steps to maximise bias control and rigour.
 
List of eligible PCI RR-friendly journals:
 

 

 

1. Schlemm, E., Frey, B. M., Mayer, C., Petersen, M., Fiehler, J., Hanning, U., Kühn, S., Twerenbold, R., Gallinat, J., Gerloff, C., Thomalla, G. & Cheng, B. (2022). Equalization of brain state occupancy accompanies cognitive impairment in cerebral small vessel disease. Biological Psychiatry, 92, 592-602. https://doi.org/10.1016/j.biopsych.2022.03.019

 

2. Ingwersen, T., Mayer, C., Petersen, M., Frey, B. M., Fiehler, J., Hanning, U., Kühn, S., Gallinat, J., Twerenbold, R., Gerloff, C., Cheng, B., Thomalla, G. & Schlemm, E. (2023). Functional MRI brain state occupancy in the presence of cerebral small vessel disease -- a pre-registered replication analysis of the Hamburg City Health Study. Acceptance of Version 2.01 by Peer Community in Registered Reports. https://github.com/csi-hamburg/HCHS-brain-states-RR/blob/f9d00adbbcf9593d8d191bf5b93912141b80ab1b/manuscript/build/main.pdf

 

How can qualitative research and case studies inform theoretical models of gaming disorder? Gaming Disorder has generated a large amount of research, with up to 95% of it focusing on quantitative studies. As a result, most of the meta-analyses and review studies focus on quantitative research and disregard qualitative approaches. However, studying the direct experiences of gamers can provide more detailed and direct evidence that can feed into theoretical models. 

 

In this Stage 1 manuscript, Auranen et al. (2024) will perform a qualitative meta-analysis of gaming disorder case studies, case reports, and case series of treatment-seekers using a 3-phase approach. First, they will focus on examining the reported problems of participants, the reported reasons for seeking help to reduce their gaming, and the causal link between gaming and reported problems, including the context of these problematic behaviors. Second, thematic synthesis will generate construct themes regarding the contexts of the individuals and the reported problems. Lastly, the authors will examine the relevance of findings in regards to the coping model, value fulfillment theory and the theory of cultural dissonance.

 

The Stage 1 submission was evaluated by the recommender and three expert reviewers, one of which was recused due to conflicts of interest that emerged after the first round of revisions. The recommender and co-recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).

 

 

Level of bias control achieved: Level 4. At least some of the data/evidence that will be used to answer the research question already exists AND is accessible in principle to the authors (e.g. residing in a public database or with a colleague), BUT the authors certify that they have not yet accessed any part of that data/evidence.
 
List of eligible PCI RR-friendly journals:

 

• Collabra: Psychology
• Peer Community Journal
• PeerJ
• Studia Psychologica
• Swiss Psychology Open

 
References

Auranen, T., Adamkovič, M., Martončik, M., Park, S., Kauraoja, V., Siutila, M., Jin, Y., & Karhulahti, V.-M. (2024). Gaming Disorder: A qualitative meta-synthesis of related case studies. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/hzc5a

Single gene alterations have been estimated to account for nearly half of neurodevelopmental conditions (NDCs), providing a crucial opportunity for animal models to understand the underlying mechanisms, causes and potential treatments. The use of systematic reviews (SRs) can, in principle, provide a powerful means to synthesise this evidence-base; however, the reporting quality of previous SRs in preclinical animal research has been found lacking (Hunniford et al., 2021). In the current study, Wilson et al. (2023) will undertook a review of systematic reviews to assess the characteristics and reporting quality of SRs that, in turn, synthesise research in genetically-modified animals to model NDCs. In particular, the authors extracted key features of reviews (including, among others, the aim and primary research questions, relevant animal model, and number of studies in the SR), in addition to quality indicators such as risk of bias and completeness of reporting. In doing so, the authors aimed to enhance guidance on the conduct and reporting of systematic reviews in this area.

 

Of twelve publications that met the preregistered search criteria, the completeness and quality of reporting was variable. Among the better reported characteristics were search strategies (9 of 12 articles), reporting of funding sources (10 of 12 articles) and use of animal data (11 of 12 articles). In contrast, only two articles reported whether the study protocol was preregistered, only three articles reported methods for assessing risk of bias, and just one included methods to analyse publication bias. In addition, the authors identified 19 review registrations via PROSPERO, most of which remained unpublished after their anticipated end dates. Overall, the results highlight the importance of adherence to reporting guidelines for increasing the transparency and reproducibility of SRs in this field.

 

The Stage 2 manuscript was evaluated over one round of in-depth review. Based on detailed responses by the authors, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
 
URL to the preregistered Stage 1 protocol: https://osf.io/952qk

 

Level of bias control achieved: Level 4. At least some of the data/evidence that was used to answer the research question already existed prior to IPA and was accessible in principle to the authors, but the authors certify that they did not access any part of that data/evidence prior to IPA.

 
List of eligible PCI RR-friendly journals:

 

• Brain and Neuroscience Advances
• F1000Research
• Human Population Genetics and Genomics
• In&Vertebrates
• Journal for Reproducibility in Neuroscience
• Peer Community Journal
• PeerJ
• Royal Society Open Science
   

 

1. Hunniford V. T., Montroy J., Fergusson D. A., Avey M. T., Wever K. E., McCann S. K., Foster M., Fox G., Lafreniere M., Ghaly M., Mannell S., Godwinska K., Gentles A., Selim S., MacNeil J., Sikora L., Sena E. S., Page M. J., Macleod M., Moher D., & Lalu M. M. (2021). Epidemiology and reporting characteristics of preclinical systematic reviews. PLOS Biology, 19:e3001177. https://doi.org/10.1371/journal.pbio.3001177

 

2. Wilson, E., Currie, G., Macleod, M., Kind, P. & Sena, E. S. (2023). Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting quality [Stage 2]. Acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/s5xd4

One of the major challenges in studies of language learning is understanding productive generalisation – the ability to use words and linguistic structures in novel settings that the learner has never encountered previously. According to discriminative learning theory, this skill arises from an iterative process of prediction and error-correction that gradually reduces uncertainty, allowing learners to discriminate linguistic outcomes and to identify informative, invariant cues for generalisation to novel cases. In the current study, Viviani et al (2022) use computational modelling to propose a central hypothesis stemming from this theory that children will learn the meaning and use of spatial adpositions (words such as “above” and “below” that describe relative positions) more effectively when there is more variability in the use of the nouns within the spatial sentences. They will also test a range of additional hypotheses, including that learning and generalisation to novel contexts will be enhanced when children learn from skewed distributions that are similar to those found in natural languages.

 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/37dxr

 

Level of bias control achieved: Level 6. Some of the data that will be used in the preregistered analyses was obtained in the second of two pilot experiments. However, since no further revisions to the analysis plan were made after this pilot, the risk of bias due to prior data observation remains zero, and the manuscript therefore qualifies for Level 6.
 
List of eligible PCI RR-friendly journals:

 

 

1. Viviani, E., Ramscar, M. & Wonnacott, E. (2022). Go above and beyond: Does input variability affect children’s ability to learn spatial adpositions in a novel language? In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/37dxr

Many products that can impact upon health and wellbeing (e.g. alcohol, food) relay information to consumers about the potential risks. However, such information is commonly provided in suboptimal format for gambling-related products. To encourage safer gambling, research has therefore recommended that information about the average loss from a gambling product (“house edge”) or percentage payout (“return-to-player”) should be communicated, with the former translating to better perceived understanding by gamblers. In this study, Newall et al. (2022) aim to experimentally compare two phrasings of the house edge against a control return-to-player to arrive at the most effective phrasing to aid gambler’s perceived chances of winning and their factual understanding of the statistical outcomes of their bet. Using a hypothetical gambling scenario, a sample of 3,000 UK-based online gamblers will be randomly assigned to receive two alternative phrasings of the house edge or the equivalent return-to-player information. Two outcome measures will be used to judge the effectiveness of the house edge information: gamblers’ perceived changes of winning and rates of accurate responding on a multiple-choice question measuring factual understanding of this information. This study will therefore assess the most effective communication of gambling risk, which can inform public health policies to reduce gambling-related harm.

 

Following a positive initial appraisal, and after two rounds of in-depth review, the recommender judged that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).

 

URL to the preregistered Stage 1 protocol: https://osf.io/5npy9
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:

 

 

 
1. Newall, P. W. S., James, R. J. E. & Maynard, O. M. (2022). How does the phrasing of house edge information affect gamblers’ perceptions and level of understanding? A Registered Report, in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/5npy9