Cerebral small vessel disease (CSVD) is a common and multi-faceted set of pathologies that affect the small arteries, arterioles, venules and capillaries of the brain. The disease manifests through a range of symptoms and conditions, including psychiatric disorders, abnormal gait, and urinary incontinence, while accounting for 25% of strokes and nearly 50% of dementia.

 

The presence of CSVD is associated with white matter lesions (WML) detected using neuroimaging, which have in turn been shown to predict future stroke, cognitive decline and dementia. While vascular risk factors of CSVD (such as hypertension and obesity) are also associated with CSVD, a complete picture of the predictive relationship between WML, cognitive decline, and blood pressure remains to be determined, as does the role of sex/gender. These inter-relationships are important to determine for improving the diagnosis and treatment of CSVD.

 

In the current study, Beyer et al. will analyse a large emerging dataset from the LIFE-Adult project – a longitudinal, two-wave, population-based study – to ask whether higher blood pressure predicts a greater increase in WML, and whether progression of WML is associated with measures of memory and executive function. In addition, the authors will explore the relationship between abdominal obesity and WML progression, and the extent to which WML progression, and its interaction with vascular risk factors, depends on sex/gender.

 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/qkbgj

 

Level of bias control achieved: Level 2. At least some data/evidence that will be used to answer the research question has been accessed and partially observed by the authors, but the authors certify that they have not yet observed the key variables within the data that will be used to answer the research question.

 
List of eligible PCI RR-friendly journals:

 

 

 

1. Beyer, F., Lammer, L., Loeffler, M., Riedel-Heller, S., Villringer, A. & Witte, V. (2023). Investigating the impact of vascular risk factors on the progression of white matter lesions, in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/qkbgj

Rapid learning in response to pain is a crucial survival mechanism, relying on forming associations between cues in the environment and subsequent pain or injury. Existing evidence suggests that associations between conditioned stimuli (cues) and unconditioned aversive stimuli (such as pain) are learned faster than for appetitive stimuli that signal pain relief. In addition, when the link between a conditioned and unconditioned stimulus is broken (by unpairing them), the extinction of this learning effect is slower for aversive that appetitive stimuli, resulting in a flatter extinction slope. Understanding why extinction slopes are reduced for aversive stimuli is important for advancing theoretical models of learning, and for devising ways of increasing the slope (and thus facilitating extinction learning) could help develop more effective methods of pain relief, particularly in the treatment of chronic pain.

 

In the current programmatic submission, Busch et al. (2023) will undertake two Registered Reports to test whether a verbal instruction intervention that explicitly informs participants about contingency changes between conditioned and unconditioned stimuli facilitates extinction learning, especially for aversive (painful) stimuli, and how changes in extinction learning relate to neural biomarkers of functional connectivity. In the first Registered Report, they will initially seek to replicate previous findings including faster acquisition of aversive than appetitive conditioned stimuli as well as incomplete extinction of aversive conditioned stimuli without verbal instruction. They will then test how the instruction intervention alters extinction slopes and the completeness of extinction for appetitive and aversive stimuli, using a range of behavioral measures (expectancy and valence ratings) and physiological measures (pupillometry, skin conductance responses). To shed light on the neural correlates of these processes, in the second Registered Report the authors will use functional magnetic resonance imaging (fMRI) to ask firstly how acquisition and extinction of aversive and appetitive conditioned responses are related to resting state brain connectivity within a network that includes ventromedial prefrontal cortex, amygdala, and striatum, and secondly, whether the effectiveness of instruction on extinction learning is associated with differences in resting state connectivity across this network.

 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).

 

URL to the preregistered Stage 1 protocol: https://osf.io/cj75p (under temporary private embargo)
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 

 

1. Busch, L., Wiech, K., Gamer, M., Knicses, B., Spisak, T., Schmidt, K., & Bingel, U. (2023). Modulatory effects of instructions on extinction efficacy in appetitive and aversive learning: A registered report. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/cj75p

Subjective tinnitus is a common disorder in which people experience a persistent sound in the absence of any external source. The underlying causes of tinnitus are debated – although the condition is strongly associated with hearing loss resulting from auditory damage, much remains to be understood about the neural processes that give rise to the phantom perception. Various classes of neurophysiological theories have been proposed, including the “altered gain” model – in which neurons in the auditory pathway increase their responsiveness to compensate for reduced auditory input following hearing loss – and the “noise cancellation” model –  in which disrupted feedback connections from limbic regions are unable to tune out phantom signals. Although these theories account for much observed data, they have not been conclusively supported, and their ability to explain tinnitus is limited by the fact that hearing loss and tinnitus can arise independently and at different times.

 

In the current study, Reisinger et al. (2023) will test an emerging alternative theory based on a Bayesian predictive-coding framework (Sedley et al., 2016) in which the alteration of perceptual priors leads the auditory system to expect a sound that, if functioning normally, it should not expect. Using magnetoencephalography (MEG) in a sample of tinnitus patients (and carefully-matched controls for age, gender, and level of hearing loss), they will ask whether tinnitus is associated with anticipatory brain activation, tuned to the carrier-frequency of an expected auditory stimulus. Specifically, the authors predict that if the predictive-coding framework is correct then individuals with tinnitus should show different regularity-dependent pre-activations of carrier- frequency-specific information compared to the control group, while tone carrier-frequencies should be processed normally in tinnitus patients. They also predict that any such pre-activations should not be related to levels of reported subjective tinnitus distress, as measured with the short version of the Tinnitus Questionnaire (mini-TQ).

 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).

 

 

Level of bias control achieved: Level 3. At least some data/evidence that will be used to the answer the research question has been previously accessed by the authors (e.g. downloaded or otherwise received), but the authors certify that they have not yet observed ANY part of the data/evidence.

 

 

• Brain and Neuroscience Advances
• Cortex
• F1000Research
• In&Vertebrates
• NeuroImage: Reports
• Peer Community Journal
• PeerJ
• Psychology of Consciousness: Theory, Research and Practice
• Royal Society Open Science

 

 

Reisinger, L., Demarchi, G., Rösch, , S., Trinka, E., Obleser, L., & Weisz, N.  (2023). Registered Report: Are anticipatory predictions enhanced in tinnitus and independent of hearing loss? In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/6gvpy

 

Sedley, W., Friston, K. J., Gander, P. E., Kumar, S., & Griffiths, T. D. (2016). An integrative tinnitus model based on sensory precision. Trends in Neurosciences, 39, 799-812. https://doi.org/10.1016/j.tins.2016.10.004

Stress is a familiar presence in modern life and may be rising in severity (Almeida et al., 2020). As a key driver of many health problems, controlling stress and its impacts is a central goal in clinical and health psychology, yet the effectiveness of existing interventions to regulate stress remains unclear. 

 

In the current study, Sparacio et al tackled this question from a meta-analytic perspective, focusing on a corpus of existing research that has addressed the efficacy of two specific stress regulation interventions: being in nature and emotional social support. As well as evaluating the evidential content of the relevant literatures, the authors also examined signs of publication bias and the moderating role of personality traits.

 

After correcting for publication bias, the results reveal evidence that being in nature is effective at reducing stress while emotional social support is not. The moderating role of personality for both interventions was inconclusive due to lack of evidence. In addition, the quality of the surveyed literature was found to be low overall, suffering from a high risk of bias and high rate of statistical reporting errors. The authors offer several recommendations to improve the rigour and quality of studies in this field, including open data, open materials, code review, preregistration and the use of Registered Reports.

 

The Stage 2 manuscript was evaluated over one round of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.

 

URL to the preregistered Stage 1 protocol: https://osf.io/c25qw

 

Level of bias control achieved: Level 3. At least some data/evidence that was used to the answer the research question had been previously accessed by the authors (e.g. downloaded or otherwise received), but the authors certify that they did not observe ANY part of the data/evidence prior to Stage 1 IPA.

 

 

• F1000Research
• Peer Community Journal
• PeerJ
• Royal Society Open Science
• Swiss Psychology Open

 

 

1. Almeida, D. M., Charles, S. T., Mogle, J., Drewelies, J., Aldwin, C. M., Spiro, A. III, & Gerstorf, D. (2020). Charting adult development through (historically changing) daily stress processes. American Psychologist, 75(4), 511–524. https://doi.org/10.1037/amp0000597

 

2. Sparacio, A., Ropovik, I., Jiga-Boy, G. M., Lağap, A. C. & IJzerman, H. (2023). Stage 2 Registered Report: Stress regulation via being in nature and social support in adults, a meta-analysis. Acceptance of version 2 by Peer Community in Registered Reports. https://doi.org/10.31234/osf.io/a4zmj

Numeracy – the ability to understand and work with numbers – is associated with a wide range of social and health-related outcomes, including socioeconomic status, employment, literacy, reasoning, and life satisfaction. A substantial body of evidence has also shown links between numeracy and decision-making, prompting the question of how it relates to finer-grained measures of reasoning, judgment and affect/emotion.

 

In the current study, Zhu and Feldman repeated four influential experiments from a study by Peters et al. (2006), which reported links between numeracy and performance on a variety of decision-making tasks, including attribute framing, frequency-percentage framing, susceptibility to affective influences, and various cognitive biases. The authors also explored several extended questions, including refinements of the original hypotheses and an examination of the relationship between numeracy and confidence in numeric judgments (subjective numeracy).

 

The results broadly constitute a successful replication, with higher numeracy associated with weaker attribute framing and susceptibility to bias. The relationship between numeracy and the frequency-percentage framing effect – that is, the change in decision-making when numbers are presented as frequencies (e.g. 5 out of 100) rather than percentages (e.g. 5%) – was inconclusive for the main analysis that treated numeracy as a categorical variable (low vs. high); however the link emerged reliably in exploratory analyses that considered numeracy as a continuous variable. The outcomes of the extended analyses were mixed, revealing evidence for a potentially weak relationship between numeracy and confidence.

 

The Stage 2 manuscript was evaluated over one round of in-depth review. Based on detailed responses to the reviewer's comments, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
 

URL to the preregistered Stage 1 protocol: https://osf.io/r73fb

 

Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA. 

 

 

 

 

1. Zhu, M. & Feldman, G. (2022). Revisiting the links between numeracy and decision making: Replication Registered Report of Peters et al. (2006) with an extension examining confidence. Acceptance of Version 5 by Peer Community in Registered Reports. https://osf.io/62wqb

 

2. Peters, E., Västfjäll, D., Slovic, P., Mertz, C. K., Mazzocco, K., & Dickert, S. (2006). Numeracy and decision making. Psychological Science, 17, 407-413. https://doi.org/10.1111%2Fj.1467-9280.2006.01720.x