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206

Title

Estimating the Effect of Reward on Sleep-Dependent Memory Consolidation – A Registered Reportuse asterix (*) to get italics

Authors

David P. Morgan, Juliane Nagel, N. Cagatay Gürsoy, Simon Kern & Gordon B. FeldPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year

2022

Picture

Abstract

<p>Rewards play an important role in guiding which memories are formed. Dopamine has been shown to be an important neuromodulator mediating the effect of rewards on memory. In rodents dopaminergic activity during learning has been shown to enhance reactivation of memory traces during sleep, the mechanism driving the benefits of sleep on consolidation. However, evidence that sleep consolidates high reward memories more strongly in humans is mixed and small samples sizes (among other factors) likely drive these inconsistencies. Therefore, we will compare memory for rewarded information between intervals of sleep and wake in a large representative online sample. Participants (N = 1750; stratified German sample) will study images associated with high and low rewards and complete a memory test directly afterwards as well as after retention. Our main prediction is that sleep will enhance the retention of high over low reward images compared to wake. In general, we also expect sleep to enhance retention (evident through a reduced decrease in performance compared to wake) and rewards to improve memory. This study will reveal whether sleep facilitates selective consolidation or whether processes at encoding and shortly thereafter suffice. Additionally, it will provide a benchmark effect size to evaluate sleep-based interventions for psychiatric disorders (e.g., addiction). It will also allow us to explore moderators of the effect, such as age and education level.</p>

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Keywords

Sleep, reward, memory consolidation

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields

Life Sciences, Social sciences

Suggested reviewers - Suggest up to 10 reviewers (provide names and Email addresses). (Optional)

No need for them to be recommenders of PCI Registered Reports. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct

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Submission date

2022-05-16 10:12:18

Recommender

Chris Chambers

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