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Title

Investigating the impact of vascular risk factors on the progression of white matter lesionsuse asterix (*) to get italics

Authors

Frauke Beyer,Laurenz Lammer, Markus Loeffler, Steffi Riedel-Heller, Arno Villringer, Veronica WittePlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year

2023

Picture

Abstract

<p>Cerebral small vessel disease (cSVD) is a major brain pathology contributing to cognitive decline and dementia. Vascular risk factors have been associated with imaging markers of cSVD such as white matter lesions, yet longitudinal studies have not comprehensively assessed these effects for abdominal obesity or reported sex-specific effects. In this pre-registered analysis of a longitudinal population-based neuroimaging cohort, we aim to fill this gap by providing a comprehensive analysis of the association of blood pressure on the progression of white matter lesions in sex-stratified analyses. We will also investigate the link of white matter lesion progression and cognitive performance. Further, we will explore the contribution of baseline abdominal obesity to white matter lesion progression and explore whether the vascular risk factors are associated with specific locations of white matter lesions.</p>

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Keywords

MRI, small vessel disease, white matter lesions, healthy aging, prevention, obesity, hypertension, vascular risk

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields

Life Sciences

Suggested reviewers - Suggest up to 10 reviewers (provide names and Email addresses). (Optional)

No need for them to be recommenders of PCI Registered Reports. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct

Opposed reviewers - Suggest up to 5 people not to invite as reviewers. (Optional)

e.g. John Doe [john@doe.com]

Submission date

2022-10-07 13:44:11

Recommender

Chris Chambers

Reviewers

Max Elliott, Isabel Garcia Garcia

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