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327

Title *

Modulatory effects of instructions on extinction efficacy in appetitive and aversive learning: A registered reportuse asterix (*) to get italics

Authors *

Lea Busch, Katja Wiech, Matthias Gamer, Balint Kincses, Tamas Spisak, Katharina Schmidt, Ulrike BingelPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2023

Picture

Abstract *

<p>In the context of pain, extinction learning has been shown to be slower or incomplete for aversive compared to appetitive cues (i.e., cues signaling pain exacerbation and pain relief, respectively), potentially due to their higher biological relevance. In a therapeutic context, this reluctant extinction that has been discussed as indicative of a ‘better safe than sorry strategy’ could potentially be reduced by making patients aware of the change in contingency. Using a classical conditioning paradigm, we will test whether slower or incomplete extinction learning from aversive than appetitive cues can be prevented when participants are explicitly informed about contingency changes using verbal instructions. Geometric figures will serve as conditioned stimuli, and individually calibrated temperature changes applied to capsaicin-pretreated skin, inducing pain exacerbation or pain relief, respectively, from tonic pain levels will serve as unconditioned stimuli. Behavioral measures (expectancy and valence ratings) and physiological measures (pupillometry, skin conductance responses) will be collected as outcome measures. Task-independent neural activity (resting-state functional magnetic resonance imaging) will be assessed prior to the behavioral paradigm. We expect stronger acquisition and extinction learning with instruction and will assess whether this effect is more pronounced for appetitive stimuli. Moreover, we intend to identify neural markers that are associated with the modulatory effects of expectations on appetitive and aversive learning.</p>

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Keywords (optional)

Instructed extinction; expectation; pain conditioning; eye tracking; rsfMRI

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Medical Sciences

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Submission date

2022-10-15 19:45:48

Recommender

Chris Chambers

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