Submit a report

Announcements

Please note that we will be CLOSED to ALL SUBMISSIONS from 1 December 2024 through 12 January 2025 to give our recommenders and reviewers a holiday break.

We are recruiting recommenders (editors) from all research fields!

Your feedback matters! If you have authored or reviewed a Registered Report at Peer Community in Registered Reports, then please take 5 minutes to leave anonymous feedback about your experience, and view community ratings.

341

Functional MRI brain state occupancy in the presence of cerebral small vessel disease -- pre-registration for a replication analysis of the Hamburg City Health Studyuse asterix (*) to get italics
Eckhard SchlemmPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"
2022
<p>Objective: To replicate recent findings about the association between the extent of cerebral small vessel disease (cSVD), functional brain network dedifferentiation and cognitive impairment.</p> <p>Methods: We will analyze demographic, imaging and behavioral data from the prospective population-based Hamburg City Health Study.<br>Using a fully prespecified analysis pipeline, we will estimate discrete brain states from structural and resting-state functional magnetic resonance imaging (MRI).<br>In a multiverse analysis we will vary brain parcellations and functional MRI confound regression strategies.<br>Severity of cSVD will be operationalised as the volume of white matter hyperintensities of presumed vascular origin.<br>Processing speed and executive dysfunction are quantified by the trail making test (TMT).</p> <p>Hypotheses: We hypothesize a) that greater volume of supratentorial white matter hyperintensities is associated with less time spent in functional MRI-derived brain states of high fractional occupancy;<br>and b) that less time spent in these high-occupancy brain states is associated with longer time to completion in part B of the TMT.&nbsp;</p>
You should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://
You should fill this box only if you chose 'Scripts were used to obtain or analyze the results'. URL must start with http:// or https://
You should fill this box only if you chose 'Codes have been used in this study'. URL must start with http:// or https://
cerebral small vessel disease, functional connectivity, brain states, magnetic resonance imaging, cognitive impairment, co-activation patterns
NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).
Life Sciences, Medical Sciences
No need for them to be recommenders of PCI Registered Reports. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct
e.g. John Doe [john@doe.com]
2022-11-19 14:21:28
Robert McIntosh