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344

Title *

Oxytocin, individual differences, and trust game behavior: a registered large-scale replicationuse asterix (*) to get italics

Authors *

Charlotte F. Kroll, Koen Schruers, Wolfgang Viechtbauer, Claudia Vingerhoets, Leonie Seidel, Arno Riedl, and Dennis HernausPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2023

Picture

Abstract *

<p>The neuropeptide oxytocin (OXT) is thought to modulate important aspects of prosocial behavior. In a seminal paper, Kosfeld et al. (2005) reported that intranasally administered OXT modulated trusting behavior in an economic trust game. Several attempts to conceptually replicate these findings yielded mixed results, which might be partly due to small sample sizes that can reduce the ability to detect, or reject, meaningful effects. Here, we propose to perform a large-scale replication (N=220) of Kosfeld et al. (2005) with specific attention for small effects and subpopulations whose trusting behavior may be sensitive to OXT manipulations. Moreover, we will conduct the largest-ever pooled analysis by merging our data with data from a previous replication by Declerck et al. (2020). Using additional (equivalence) analyses, we aim to refute effect sizes of OXT on interpersonal trust that will not be worthwhile pursuing in most lab-based contexts. Our study will contribute to a more refined understanding of OXT’s involvement in human social behavior, for example by identifying boundary conditions that will delineate when OXT-induced effects on prosocial behavior may occur. Critically, we anticipate that our work will offer a more realistic perspective on the effect sizes that can be expected when using intranasal OXT to modulate prosocial behavior.</p>

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Keywords (optional)

Oxytocin, trust game, replication, individual differences, pooled analysis

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Life Sciences, Social sciences

Suggested reviewers - Suggest up to 10 reviewers (provide names and Email addresses). (Optional)

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No need for them to be recommenders of PCI Registered Reports. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct

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Submission date

2022-11-25 18:07:23

Recommender

Romain Espinosa

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