Social cognition involves complex processes including empathy, mentalizing, and compassion, which rely on structural connectivity and specifically white matter (WM) integrity. Prior research suggests that deficits in social cognition are linked to deficient structural connectivity, indicating that the latter might be an essential foundation for social cognitive abilities. In the current study, Hansl et al. (2025) explore the relationship between social cognition and white matter (WM) integrity in the brain across different populations, by means of a systematic review and meta-analyses. Using diffusion-weighted imaging data, the authors aim to identify specific WM tracts most associated with social cognition. Meta-analyses of region-of-interest (ROI)-based studies will provide further insights, while meta-regression and subgroup analyses will examine differences across social cognitive constructs, imaging metrics, clinical conditions, and age groups. The findings could clarify global and specific WM contributions to social cognition, guiding future research on brain structure-function relationships in social cognition across various populations.

 

The Stage 1 submission was evaluated by two expert reviewers. After two rounds of revision, the recommender judged that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).

 

URL to the preregistered Stage 1 protocol: https://osf.io/6n3jy (under temporary private embargo)

 

Level of bias control achieved: Level 2. At least some data/evidence that will be used to answer the research question has been accessed and partially observed by the authors, but the authors certify that they have not yet observed the key variables within the data that will be used to answer the research question and they have taken additional steps to maximise bias control and rigour.

 
List of eligible PCI RR-friendly journals:
 

 

 

1. Hansl, R., Maliske, L. Z., Valk, S. L., & Kanske, P. (2025). Social cognition as a matter of structural brain connections? A systematic review and diffusion weighted imaging meta-analysis. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/6n3jy