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Title *

Arithmetic deficits in Parkinson's Disease? A registered reportuse asterix (*) to get italics

Authors *

Hannah D. Loenneker, Inga Liepelt-Scarfone, Klaus Willmes, Hans-Christoph Nuerk, & Christina ArtemenkoPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2022

Picture

Abstract *

<p>Elderly people and patients with neurodegenerative diseases such as Parkinson’s Disease (PD) immensely rely on arithmetic skills to lead an independent life. Activities such as medication management, financial transactions or using public transport require intact abilities to manipulate numbers with different arithmeticoperations. However, research on cognitive deficits in PD has been focussing on domain-general functions such as executive functions, attention or working memory so far – largely neglecting potential domain-specific aspects of numerical cognition (e.g., carry or problem size effect). These aspects should be addressed, as PD-immanent deterioration of domain-specific numerical areas and domain-general functions suggests mechanisms of both primary and secondary (mediated by other cognitive deficits) arithmetic deficits, respectively. The current study will systematically investigate arithmetic performance and effects in PD patients differing in cognitive impairment for the first time, targeting domain-specific cognitive representations of arithmetic as well as the influence of domain-general factors. Besides healthy controls (HC), PD patients with normal cognition (PD-NC) and PD patients with mild cognitive impairment (PD-MCI) will be compared in arithmetic performance in the four basic operations (addition, subtraction, multiplication, division). Discriminant analysis will be employed to assess whether performance in arithmetic tasks can differentiate between a healthy control group and both PD groups. The study results will help us to understand the underlying mechanisms of arithmetic deficits faced by PD patients in daily life.</p>

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Keywords (optional)

Parkinson’s disease, mild cognitive impairment, arithmetic operation, calculation, place × value system

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Life Sciences

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Submission date

2021-06-29 19:23:53

Recommender

Zoltan Dienes

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