Causal dynamics of task-relevant rule and stimulus processing in prefrontal cortexuse asterix (*) to get italics

Jade Buse Jackson Runhao Lu Alex WoolgarPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

2023

<p>The dorsolateral prefrontal cortex (dlPFC) is understood to be important for cognitive flexibility, enabling us to switch between different contexts or rules, and to selectively attend to the relevant aspects of a task. Conversely, the dorsomedial prefrontal cortex (dmPFC), a region of the default mode network, has been shown to deactivate in response to externally focused tasks and is typically thought to have a contrasting function to dlPFC, for example engaging in self-reflection and internally generated thought. In this study we will test the causal role of these regions by delivering transcranial magnetic stimulation (TMS) during a task that requires participants to select the relevant rule and then attend to the relevant stimulus feature of a novel object. We will apply a train of 3 suprathreshold TMS pulses (13 Hz) at one of two time windows on every trial, with the aim of interrupting processes involved in either selecting the relevant rule and/or the relevant stimulus feature. Time windows will be selected based on the dynamics of rule and stimulus coding from magnetoencephalography (MEG) data on the same paradigm. Behavioural errors will be categorised as rule- or stimulus-based dependent on the button pressed. We will examine how rule and stimulus-based errors vary with stimulation time window (early, late), and condition (active dlPFC, sham dlPFC, active dmPFC, sham dmPFC). We predict a higher percentage of rule-based errors in the active dlPFC compared to the sham dlPFC condition and at the earlier stimulation time window compared to the later stimulation time window, while the later compared to the earlier stimulation time window will result in a higher percentage of stimulus-based errors. The data from this study will have the potential to temporally distinguish between different stages of task processing and the contributing role of dlPFC compared to dmPFC in a causal framework.&nbsp;</p>

Selective attention; Cognitive control; TMS; dlPFC; Rule; Default Mode Network

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Life Sciences

Patrick Bissett [pbissett@stanford.edu] suggested: Hi Chris, , Patrick Bissett [pbissett@stanford.edu] suggested: Thanks for reaching out, and I'm sorry that I won't be able to review this one for a couple reasons: I'm overcommitted at the moment and this seems like it might be a bit outside my expertise. However, please keep me in mind for future reviews. , Patrick Bissett [pbissett@stanford.edu] suggested: You might consider asking Jan Wessel (jan-wessel@uiowa.edu), given his experience with multimodal studies of control and control adjustments. , Patrick Bissett [pbissett@stanford.edu] suggested: Best, , Patrick Bissett [pbissett@stanford.edu] suggested: Patrick, Jan Wessel [jan-wessel@uiowa.edu] suggested: Chris, I'm swamped right now with study section, sorry. You may try Jiefeng Jiang or Eliot Hazeltine in my department at Iowa. Same Email layout (first-last@uiowa.edu). , Jan Wessel [jan-wessel@uiowa.edu] suggested: Jan, Eva Feredoes [e.a.feredoes@reading.ac.uk] suggested: I am sorry! I would actually love to review this, but have a conflict of interest (we're working together on manuscript + collaborating). , Eva Feredoes [e.a.feredoes@reading.ac.uk] suggested: I can recommend these alternative reviewers who specialise in TMS and/or cognitive control research: , Eva Feredoes [e.a.feredoes@reading.ac.uk] suggested: 1. Derek Nee, Florida State University: derek.evan.nee@gmail.com , Eva Feredoes [e.a.feredoes@reading.ac.uk] suggested: 2. Jeff Johnson, North Dakota State University: jeffrey.s.johnson@ndsu.edu , Eva Feredoes [e.a.feredoes@reading.ac.uk] suggested: 3. Jason Samaha, University of California Santa Cruz: jsamaha@ucsc.edu , Eva Feredoes [e.a.feredoes@reading.ac.uk] suggested: 4. Nathan Rose, Notre Dame University: nrose1@nd.edu , Eva Feredoes [e.a.feredoes@reading.ac.uk] suggested: I hope this helps! , Eva Feredoes [e.a.feredoes@reading.ac.uk] suggested: Apologies again for not being able to help with this one. , Eva Feredoes [e.a.feredoes@reading.ac.uk] suggested: Eva, Emiel Cracco suggested: Carina Giesen, Senne Braem, Carina Giesen [carina.giesen@health-and-medical-university.de] suggested: Please try the following colleagues: , Carina Giesen [carina.giesen@health-and-medical-university.de] suggested: Dr Christoph Geissler, Uni Trier: geisslerc@uni-trier.de , Carina Giesen [carina.giesen@health-and-medical-university.de] suggested: Prof Christian Frings, Uni Trier: chfrings@uni-trier.de, Derek Nee [derek.evan.nee@gmail.com] suggested: Apologies - I am over-extended on service activities at the moment. Some alternate suggestions: , Derek Nee [derek.evan.nee@gmail.com] suggested: p.muhle-karbe@bham.ac.uk , Derek Nee [derek.evan.nee@gmail.com] suggested: akiyonaga@ucsd.edu , Derek Nee [derek.evan.nee@gmail.com] suggested: theresa_desrochers@brown.edu, Anastasia Kiyonaga suggested: Justin Riddle, jriddle@fsu.edu , Anastasia Kiyonaga suggested: Derek Nee, nee@psy.fsu.edu, Max Friehs suggested: Sorry but I just am not free currently to invest time into this even though the manuscript is of great interest to me. , Max Friehs suggested: I suggest contacting for example Philipp Kuhnke kuhnke@cbs.mpg.de, Gesa Hartwigsen hartwigsen@cbs.mpg.de or Bernhard Pastötter pastoetter@uni-trier.de, Bernhard Pastötter [pastoetter@uni-trier.de] suggested: Thank you very much for your invitation. Unfortunately, I am not an expert on TMS. , Bernhard Pastötter [pastoetter@uni-trier.de] suggested: Reviewer Suggestion: , Bernhard Pastötter [pastoetter@uni-trier.de] suggested: Moritz Julian Maier, Center for Responsible Research and Innovation at the Fraunhofer IAO, Hardenbergstraße 20, 10623 Berlin, Germany. , Bernhard Pastötter [pastoetter@uni-trier.de] suggested: Email: Moritz-julian.maier@iao.fraunhofer.de

e.g. John Doe john@doe.com

No need for them to be recommenders of PCI Registered Reports. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct

2023-09-28 13:13:30

Chris Chambers