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Title

Functional MRI brain state occupancy in the presence of cerebral small vessel disease -- pre-registration for a replication analysis of the Hamburg City Health Studyuse asterix (*) to get italics

Authors

Eckhard SchlemmPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year

2022

Picture

Abstract

Objective: To replicate recent findings about the association between the extent of cerebral small vessel disease (cSVD), functional brain network dedifferentiation and cognitive impairment. Methods: We will analyze demographic, imaging and behavioral data from the prospective population-based Hamburg City Health Study. Using a fully prespecified analysis pipeline, we will estimate discrete brain states from structural and resting-state functional magnetic resonance imaging (MRI). In a multiverse analysis we will vary brain parcellations and functional MRI confound regression strategies. Severity of cSVD will be operationalised as the volume of white matter hyperintensities of presumed vascular origin. Processing speed and executive dysfunction are quantified by the trail making test (TMT). Hypotheses: We hypothesize a) that greater volume of supratentorial white matter hyperintensities is associated with less time spent in functional MRI-derived brain states of high fractional occupancy; and b) that less time spent in these high-occupancy brain states is associated with longer time to completion in part B of the TMT.

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Keywords

cerebral small vessel disease, functional connectivity, brain states, magnetic resonance imaging, cognitive impairment, co-activation patterns

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields

Life Sciences, Medical Sciences

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Submission date

2022-11-19 14:21:28

Recommender

Robert McIntosh

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