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57 records found
IdTitleAuthorsAbstractPictureThematic fieldsRecommenderReviewersSubmission date
23 Jan 2023
STAGE 1
toto

Genetically-modified animals as models of neurodevelopmental conditions: an umbrella review

Evaluating the quality of systematic reviews in preclinical animal studies of neurodevelopmental conditions

Recommended by based on reviews by Marietta Papadatou-Pastou and Richel Bilderbeek
Single gene alterations have been estimated to account for nearly half of neurodevelopmental conditions (NDCs), providing a crucial opportunity for animal models to understand the underlying mechanisms, causes and potential treatments. The use of systematic reviews (SRs) can, in principle, provide a powerful means to synthesise this evidence-base; however, the reporting quality of previous SRs in preclinical animal research has been found lacking (Hunniford et al., 2021). In the current study, Wilson et al. (2023) will undertake an umbrella review – a systematic review of systematic reviews – to assess the characteristics and reporting quality of SRs that, in turn, synthesise research in genetically-modified animals to model NDCs. In particular, the authors will extract key features of reviews (including, among others, the aim and primary research questions, relevant animal model, and number of studies in the SR), in addition to quality indicators such as risk of bias and completeness of reporting. In doing so, the authors aim to enhance guidance on the conduct and reporting of systematic reviews in this area.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/952qk
 
Level of bias control achieved: Level 4. At least some of the data/evidence that will be used to answer the research question already exists AND is accessible in principle to the authors BUT the authors certify that they have not yet accessed any part of that data/evidence.
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Hunniford V. T., Montroy J., Fergusson D. A., Avey M. T., Wever K. E., McCann S. K., Foster M., Fox G., Lafreniere M., Ghaly M., Mannell S., Godwinska K., Gentles A., Selim S., MacNeil J., Sikora L., Sena E. S., Page M. J., Macleod M., Moher D., & Lalu M. M. (2021). Epidemiology and reporting characteristics of preclinical systematic reviews. PLOS Biology, 19:e3001177. https://doi.org/10.1371/journal.pbio.3001177
 
2. Wilson, E., Currie, G., Macleod, M., Kind, P. & Sena, E. S. (2023). Genetically-modified animals as models of neurodevelopmental conditions: an umbrella review, in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/952qk
Genetically-modified animals as models of neurodevelopmental conditions: an umbrella reviewEmma Wilson; Gillian Currie; Malcolm Macleod; Peter Kind; Emily S Sena<p><strong>Objective</strong><br>Using genetically-modified animals to model neurodevelopmental conditions (NDCs) helps better our understanding of their underlying biology. In vivo research has unique characteristics not shared with clinical rese...Life SciencesChris Chambers2022-08-29 12:08:51 View
23 Jan 2023
STAGE 1
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Comparing time versus money in sunk cost effects: Replication of Soman (2001)

Are sunk cost effects weaker for time than money?

Recommended by based on reviews by Johanna Peetz, Christopher Olivola, David Ronayne, Johannes Leder and Dilip Soman
The sunk cost fallacy is a cognitive bias in which people persist with a decision that is no longer optimal because of previous resources they have invested (now considered to be spent or “sunk”). Most of us will have heard sunk costs reflected in the saying “throwing good money after bad”, but sunk costs can, in theory, occur more broadly, whether for money, time or any other resource-limited investment. The sunk cost effect for money has been widely studied and appears robust; in contrast, the sunk cost effect for time is more uncertain, and is potentially moderated by the age of respondents (and likely resource availability), the fact that time is irreplaceable, and the tendency for people to account for time less easily than they do for money. In an impactful study, Soman (2001) found that the sunk cost effect for time was indeed weaker than for money, although this finding has not been widely replicated.
 
In the current study, Petrov et al. (2023) propose a replication of three studies from Soman (2001), asking whether sunk costs are weaker for time than for money, and then testing whether the relative absence of a sunk time cost arises from the inability of participants to account for time or due to more rational beliefs in the evaluation of past time investments.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/u34zb
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Soman, D. (2001). The mental accounting of sunk time costs: Why time is not like money. Journal of Behavioral Decision Making,14, 169-185. https://doi.org/10.1002/bdm.370
 
2. Petrov, N. B., Chan, Y. K., Lau, C. N., Kwok, T. H., Chow, L. C., Lo, W. Y. V, Song W., & Feldman, G. (2023). Sunk cost effects for time versus money: Replication of Soman (2001) [Registered Report Stage 1], in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/u34zb
Comparing time versus money in sunk cost effects: Replication of Soman (2001) Nikolay Petrov, Wenkai Song, Yin Kan (Megan) CHAN, Cheuk Nam (Chris) LAU, Tin Ho (Donald) KWOK, Lok Ching (Estelle) CHOW, Wai Yan (Vivian) LO, Gilad Feldman (gfledman@hku.hk)<p>This is a scheduled PCI-RR snap shot for a planned project: "Comparing time versus money in sunk cost effects: Replication of Soman (2001) ​"</p>Social sciencesChris Chambers2022-02-23 10:39:42 View
23 Jan 2023
STAGE 1
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Responding to Online Toxicity: Which Strategies Make Others Feel Freer to Contribute, Believe That Toxicity Will Decrease, and Believe that Justice Has Been Restored?

Testing antidotes to online toxicity

Recommended by based on reviews by Corina Logan and Marcel Martončik
Social media is a popular tool for online discussion and debate, bringing with it various forms of hostile interactions –  from offensive remarks and insults, to harassment and threats of physical violence. The nature of such online toxicity has been well studied, but much remains to be understood regarding strategies to reduce it. Existing theory and evidence suggests that a range of responses – including those that emphasise prosociality and empathy – might be effective at mitigating online toxicity. But do such strategies work in practice?
 
In the current study, Young Reusser et al (2023) propose an experiment to test the effectiveness of three types of responses to online toxicity – Benevolent Correction (including disagreement), Benevolent Going Along (including joking/agreement), or Retaliation (additional toxicity) – on how able participants feel to contribute to conversations, their belief that the toxicity would be reduced by the intervention, and their belief that justice had been restored. The findings promise to shed light on approaches for improving the health of online discourse.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/hfjnb (under temporary private embargo)
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Young Reusser, A. I., Veit, K. M., Gassin, E. A., & Case, J. P. (2023). Responding to Online Toxicity: Which Strategies Make Others Feel Freer to Contribute, Believe That Toxicity Will Decrease, and Believe that Justice Has Been Restored? In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/hfjnb
Responding to Online Toxicity: Which Strategies Make Others Feel Freer to Contribute, Believe That Toxicity Will Decrease, and Believe that Justice Has Been Restored?Alison I. Young Reusser, Houghton University; Kristian Veit, Olivet Nazarene University; Lisa Gassin, Olivet Nazarene University; Jonathan Case, Houghton University<p>When we encounter toxic comments online, how might individual efforts to reply to those comments improve others’ experiences conversing in that forum? Is it more helpful for others to publicly, but benevolently (with a polite tone, demonstrated...Social sciencesChris Chambers2022-06-08 18:35:48 View
20 Jan 2023
STAGE 2
(Go to stage 1)
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No reliable effect of task-irrelevant cross-modal statistical regularities on distractor suppression

Failure to learn cross-modally to suppress distractors

Recommended by based on reviews by Miguel Vadillo and 1 anonymous reviewer
There are two fundamental processes that the brain engages in: statistical learning and selection. Indeed, past work has shown these processes often come together: People can use a task-irrelevant stimulus to predict a target stimulus even in different modalities (crossmodal statistical learning), thereby enhancing the processing of the target stimulus (selection). Further, people can learn where a distractor will be in order to efficiently suppress it (selecting out), using task irrelevant stimuli in the same modality (within-modality statistical learning).
 
In two experiments Jagini and Sunny found that people did not learn to use a task-irrelevant stimulus from a different modality (cross modal statistical learning) to suppress a distractor (selecting out). They also found that people had little awareness of the relation between the predictor task-irrelevant stimulus and the location of the distractor. The results may reflect limits on what can be achieved unconsciously.
 
Following peer review, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
 
URL to the preregistered Stage 1 protocol: https://osf.io/qjbmg
 
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question existed prior to Stage 1 in-principle acceptance.
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Jagini, K. K. & Sunny, M. M. (2023). No reliable effect of task-irrelevant cross-modal statistical regularities on distractor suppression. Stage 2 Registered Report, acceptance of Version 4 by Peer Community in Registered Reports. https://doi.org/10.31234/osf.io/d8wes
No reliable effect of task-irrelevant cross-modal statistical regularities on distractor suppressionKishore Kumar Jagini, Meera Mary Sunny<p>Our sensory systems are known to extract and utilize statistical regularities in sensory inputs across space and time for efficient perceptual processing. Past research has shown that participants can utilize statistical regularities of target ...Humanities, Life Sciences, Social sciencesZoltan Dienes2022-11-21 15:30:30 View
18 Jan 2023
STAGE 1
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Beneath the label: Assessing video games’ compliance with ESRB and PEGI loot box warning label industry self-regulation

How effective is self-regulation in loot box labelling?

Recommended by based on reviews by Pete Etchells and Jim Sauer
Paid loot boxes – items bought for real-world money that offer randomised rewards – are a prevalent feature of contemporary video games (Zendle et al., 2020). Because they employ random chance to provide rewards after spending real money, loot boxes have been considered a form of gambling, raising concerns about risk of harm to children and other vulnerable users. In response, some countries have taken legal steps to regulate and even ban the use of loot boxes, with only limited success so far (Xiao, 2022). At the same time, the Entertainment Software Rating Board (ESRB) and PEGI (Pan-European Game Information) now expect games that contain loot boxes to be marked with warning labels that, in theory, will enable users (including parents) to make more informed decisions. These requirements by ESRB/PEGI are not legally binding and may be considered a form of industry self-regulation.
 
In the current study, Xiao (2023) will investigate the effectiveness of self-regulation in the use of loot box labels. Study 1 examines the consistency of warning labels by the ESRB and PEGI, with the expectation that if self-regulation works as it should then these labels should always (or nearly always) co-occur. Study 2 establishes the compliance rate for labelling among popular games that are known to contain loot boxes, with a rate of ≥95% considered to be successful. The findings should prove useful in identifying the success or failure of self-regulation as a means of ensuring industry compliance with loot box labelling.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/e6qbm
 
Level of bias control achieved: Level 3. At least some data/evidence that will be used to the answer the research question has been previously accessed by the authors (e.g. downloaded or otherwise received), but the authors certify that they have not yet observed ANY part of the data/evidence.
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Zendle, D., Meyer, R., Cairns, P., Waters, S., & Ballou, N. (2020). The prevalence of loot boxes in mobile and desktop games. Addiction, 115(9), 1768-1772. https://doi.org/10.1111/add.14973

2. Xiao, L. Y. (2022). Breaking Ban: Belgium’s ineffective gambling law regulation of video game loot boxes. Stage 2 Registered Report, acceptance of Version 2 by Peer Community in Registered Reports. https://doi.org/10.31219/osf.io/hnd7w 
 
3. Xiao, L. Y. (2023). Beneath the label: Assessing video games’ compliance with ESRB and PEGI loot box warning label industry self-regulation, in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/e6qbm
Beneath the label: Assessing video games’ compliance with ESRB and PEGI loot box warning label industry self-regulationLeon Y. Xiao<p>Loot boxes in video games are a form of in-game transactions with randomised elements. Concerns have been raised about loot boxes’ similarities with gambling and their potential harms (e.g., overspending). Recognising players’ and parents’ conc...Humanities, Social sciencesChris Chambers2022-09-17 00:14:51 View
17 Jan 2023
STAGE 1
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How long does it take to form a habit?: A Multi-Centre Replication

How much practice is needed before daily actions are performed in a way that feels habitual?

Recommended by based on reviews by Benjamin Gardner, Wendy Wood and Adam Takacs
Even small changes in daily life can have a significant impact on one’s health, for example going to the gym at regular times and eating a healthy breakfast. But how long must we do something before it becomes a habit? Lally et al. (2010) tracked the subjective automaticity of a novel, daily (eating or exercise-related) routine. Based on 39 participants, they found a median time of 66 days. This estimate has never been replicated with their exact procedure, so the question remains of how well this holds up. Yet the estimate is useful for knowing how long we have to effortfully make ourselves perform an action until we will do it automatically.
 
In the current study, de Wit et al. (2023) propose a four-centre near-exact replication of Lally et al. (2010), for which they aim to test 800 subjects to provide a precise estimate of the time it takes to form a habit.
 
The Stage 1 manuscript was evaluated over four rounds of review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/bj9r2
 
Level of bias control achieved: Level 4. At least some of the data/evidence that will be used to answer the research question already exists AND is accessible in principle to the authors (e.g. residing in a public database or with a colleague), BUT the authors certify that they have not yet accessed any part of that data/evidence.
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Lally, P., van Jaarsveld, C. H. M., Potts, H. W. W., & Wardle, J. (2010). How are habits formed: Modelling habit formation in the real world. European Journal of Social Psychology, 40, 998–1009. https://doi.org/10.1002/ejsp.674
 
2. de Wit, S., Bieleke, M., Fletcher, P. C., Horstmann, A., Schüler, J., Brinkhof, L. P., Gunschera, L. J., AND Murre, J. M. J. (2023). How long does it take to form a habit?: A Multi-Centre Replication, in principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/bj9r2
How long does it take to form a habit?: A Multi-Centre Replicationde Wit, S., Bieleke, M., Fletcher, P.C., Horstmann, A., Schüler, J., Brinkhof, L.P., Gunschera, L.J., Murre, J.M.J.<p>How long does it take to form a habit? This question will be addressed by an innovative study by Lally et al. (2010), in which they tracked the subjective automaticity of a novel, daily (eating or exercise-related) routine, using the Self-Repor...Social sciencesZoltan Dienes2022-05-26 09:54:26 View
17 Jan 2023
STAGE 1
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Similarities and differences in a global sample of song and speech recordings

Exploring cross-cultural variation in speech and song

Recommended by based on reviews by Bob Slevc, Nai Ding and 1 anonymous reviewer
For centuries, the ubiquity of language and music across human societies has prompted scholars to speculate about their cross-cultural origins as well as their shared and unique characteristics. Depending on the extent to which contemporary theories emphasise the role of biology vs. culture, a range of hypotheses have been proposed concerning expected similarities and differences in song and speech. One class of hypotheses stemming from cultural relativism assumes a lack of universal regularities in song and speech, and therefore predicts no systematic cross-cultural relationships. On the other hand, more recent evolutionary hypotheses such as the social bonding hypothesis, motor constraint hypothesis, and sexual selection hypothesis all predict differences or similarities in specific characteristic of vocalisations, such as pitch regularity, pitch interval size, and melodic contour. Existing results are mixed in their support of these predictions.
 
In the current study, Ozaki et al. (2022) embark on an ambitious project to elucidate cross-cultural similarities and differences between speech and song in 81 different linguistic varieties spanning 23 language families. Understanding precisely how song and speech are related is methodologically challenging due to the multitude of confounds that can arise in comparing natural recordings. Here the authors overcome these difficulties with four types of carefully controlled recordings: singing, recitation of sung lyrics, spoken description of the song, and instrumental version of the sung melody. The authors will then examine six features that are amenable to reliable comparison, including pitch height, temporal rate, pitch stability, timbral brightness, pitch interval size, and pitch declination. With this data in hand, the authors will ask which acoustic features differ reliably between song and speech across cultures, with the expectation that song will exhibit higher pitch, slower rate and more stable pitch than speech. At the same time, the authors expect song and speech to be reliably similar in the characteristics of timbral brightness, pitch intervals and pitch contours. In addition to these confirmatory tests, the authors will explore variation across a range of additional stimulus characteristics and ancillary research questions.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/jdhtz
 
Level of bias control achieved: Level 2. At least some data/evidence that will be used to answer the research question has been accessed and partially observed by the authors, but the authors certify that they have not yet observed the key variables within the data that will be used to answer the research question AND they have taken additional steps to maximise bias control and rigour.

List of eligible PCI RR-friendly journals:
 
 
References
 
1. Ozaki, Y., Savage P. E. et al. (2022). Similarities and differences in a global sample of song and speech recordings, in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/jdhtz
Similarities and differences in a global sample of song and speech recordingsCorresponding authors: Yuto Ozaki and Patrick E. Savage (Keio University, Japan). Full list of 80 authors is in the manuscript<p>What, if any, similarities and differences between song and speech are consistent across cultures? Both song and speech are found in all known human societies and are argued to share evolutionary roots and cognitive resources, yet no studies ha...Social sciencesChris Chambers Bob Slevc, Nai Ding2022-09-16 16:03:10 View
02 Dec 2022
STAGE 1
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Revisiting the link between anthropomorphism and loneliness with an extension to free will belief: Replication and extensions of Epley et al. (2008)

Are loneliness and free will beliefs associated with anthropomorphism?

Recommended by based on reviews by John Protzko and Marieke Wieringa
Anthropomorphism is a widespread phenomenon in which people instil non-human entities or objects with human-like characteristics, such as motivations, intentions, and goals. Although common, the tendency to anthropomorphise varies between people, and a growing body of psychological research has examined the importance of various individual differences. One major theoretical account of anthropomorphism (Epley et al. 2007) suggests that sociality motivation – the drive to establish social relationships – is a key moderator of the phenomenon. In support of this account, some evidence suggests that people who experience greater loneliness (a proposed marker of sociality motivation) are more likely to anthropomorphise. In an influential series of studies, Epley et al. (2008) found that anthropomorphism and loneliness were positively correlated and that inducing participants experimentally to feel more lonely led to greater anthropomorphism. Later studies, however, produced more mixed results, particularly concerning the effectiveness of the experimental interventions.
 
In the current study, Elsherif et al. (2022) propose a partial replication of Epley et al. (2008), focusing on the correlational relationship between anthropomorphism and loneliness, with extensions to examine free will beliefs, anthropomorphism for supernatural beings (in addition to objects/gadgets), and the extent to which participants judged objects/gadgets to be controllable.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/by89c
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Epley, N., Waytz, A., & Cacioppo, J. T. (2007). On seeing human: A three-factor theory of anthropomorphism. Psychological Review, 114, 864–886. https://doi.org/10.1037/0033-295X.114.4.864 
 
2. Epley, N., Akalis, S., Waytz, A., & Cacioppo, J. T. (2008). Creating social connection through inferential reproduction: Loneliness and perceived agency in gadgets, Gods, and greyhounds. Psychological Science, 19, 114–120. https://doi.org/10.1111/j.1467-9280.2008.02056.x 
 
3. Elsherif, M., Pomareda, C., Xiao, Q., Chu, H. Y., Tang, M. C., Wong, T. H., Wu, Y. &  Feldman, G. (2022). Revisiting the positive association between loneliness and anthropomorphism with an extension to belief in free will: Replication and extensions of Epley et al. (2008), in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/by89c
Revisiting the link between anthropomorphism and loneliness with an extension to free will belief: Replication and extensions of Epley et al. (2008)Mahmoud Elsherif, Christina Pomareda, Qinyu Xiao, Hoi Yan Chu, Ming Chun Tang, Ting Hin (Angus) Wong, Yiming Wu, Gilad Feldman<p>This is a scheduled PCI-RR snap shot for a planned project: "Revisiting the link between anthropomorphism and loneliness with an extension to free will belief: Replication and extensions of Epley et al. (2008)​"</p>Social sciencesChris Chambers2022-02-16 07:03:50 View
01 Dec 2022
STAGE 1
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Cerebral lateralization of writing in students at risk for dyslexia using functional Transcranial Doppler ultrasonography

Lateralisation for written language in primary school students at risk for dyslexia

Recommended by based on reviews by Margriet Groen and Todd Richards
While cerebral lateralisation for oral language is well-characterised, cerebral lateralisation for written language is much less well-understood. In this study, Papadopoulou et al. (2022) will use functional transcranial Doppler ultrasonography to assess lateralisation for written language in 7- to 9-year-old children at risk for dyslexia and neurotypical children. They will use tasks that assess efficiency in reading and writing names as well as speed and fluency in writing. The findings of this manuscript will highlight whether children with dyslexia showed atypical lateralisation for language in a written task. In addition, the authors plan to explore the correlation between lateralisation and writing competence. 
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on the edits made to the manuscript, and detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/u54tk (under temporary private embargo)
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Papadopoulou, A.-K., Vlachos, F., Pervanidou, P., Anesiadou, S., Antoniou, F., Phylactou, P., Badcock, N.A. & Papadatou-Pastou, M. (2022). Cerebral lateralization of writing in students at risk for dyslexia using functional Transcranial Doppler ultrasonography, in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/u54tk (under temporary private embargo)
Cerebral lateralization of writing in students at risk for dyslexia using functional Transcranial Doppler ultrasonographyAnastasia-Konstantina Papadopoulou, Filippos Vlachos, Panagiota Pervanidou, Sofia Anesiadou, Faye Antoniou, Phivos Phylactou, Nicholas A. Badcock, Marietta Papadatou-Pastou<p>It is well established that the left hemisphere is dominant in oral language in the majority of neurotypical individuals, while a more symmetrical pattern of activation in shown in cases of language disorders, such as dyslexia. Cerebral lateral...Humanities, Life Sciences, Social sciencesSaloni Krishnan Margriet Groen, Todd Richards2022-06-06 09:00:26 View
22 Nov 2022
STAGE 1
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Estimating the Effect of Reward on Sleep-Dependent Memory Consolidation – A Registered Report

How does reward influence the effect of sleep on memory?

Recommended by based on reviews by 2 anonymous reviewers
Sleep and reward each have an important role in human memory. According to the active system consolidation hypothesis, memory consolidation during sleep originates from the repeated reactivation of memory representations that were encoded during wake (Rasch & Born, 2013). Research has also consistently shown that memory performance is enhanced for items or stimuli associated with higher vs. lower rewards. While these lines of evidence are relatively clear, the role of sleep in shaping the interaction between reward and memory is more opaque, likely due to a combination of methodological variation between studies but also due to the field’s reliance on small-N designs and biased reporting practices. Clarifying this three-way relationship, and setting field benchmarks for effect sizes, is crucial not only for building richer neurocognitive models of memory, but for clinical applications such as targeted sleep interventions to treat addiction and other forms of mental illness. 
 
Using a large, stratified online German sample (N=1750), Morgan et al. (2022) will study the three-way relationship between sleep, reward and memory by asking whether, and if so how, reward influences the magnitude of sleep-dependent memory consolidation. Using an AM:PM-PM:AM design in combination with a motivated learning task, the authors will address three main questions: first, whether sleep yields greater memory performance compared to an equivalent period of wake; second whether information associated with higher reward leads to greater memory performance compared to lower reward; and third, the crucial interaction of whether sleep causes greater recognition memory performance for higher vs. lower reward items. The design also includes a series of rigorous positive controls to confirm testability of the hypotheses, while measuring a host of additional moderating variables for exploratory analyses (including age, education status, mental health, and more).
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/q5pk8
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Rasch, B. & Born, J. (2013). About Sleep's Role in Memory. Physiological Revews, 93, 681–766. https://doi.org/10.1152%2Fphysrev.00032.2012
 
2. Morgan, D. P., Nagel, J., Cagatay Gürsoy, N., Kern, S. & Feld, G. B. (2022). Estimating the effect of reward on sleep-dependent memory consolidation – A Registered Report, in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/q5pk8
Estimating the Effect of Reward on Sleep-Dependent Memory Consolidation – A Registered ReportDavid P. Morgan, Juliane Nagel, N. Cagatay Gürsoy, Simon Kern & Gordon B. Feld<p>Rewards play an important role in guiding which memories are formed. Dopamine has been shown to be an important neuromodulator mediating the effect of rewards on memory. In rodents dopaminergic activity during learning has been shown to enhance...Life Sciences, Social sciencesChris Chambers2022-05-16 10:12:18 View