Frontotemporal dementia (FTD) refers to a range of neurodegenerative diseases involving progressive deterioration of frontal and temporal brain networks. This scoping review protocol by Carneiro et al. (2024) promises to make a valuable contribution to the conceptualization of dysregulated interoception (the ability to sense and interpret internal bodily signals) and allostasis (anticipation and adjustment of energy use in response to environmental demands) in the context of FTD. The work also has broader implications, potentially offering key insights into the interplay between sensory and regulatory signals, which hold relevance not only for dementia but also for other mental disorders characterized by maladaptive allostatic adaptations, such as addiction. This broader applicability underscores the potential impact of the review across multiple domains of mental health research.

 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on ​detailed responses to reviewers’ and the recommender’s comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.​​​
 
URL to the preregistered Stage 1 protocol: https://osf.io/skebz
 
Level of bias control achieved: Level 2. At least some data/evidence that will be used to answer the research question has been accessed and partially observed by the authors, but the authors certify that they have not yet observed the key variables within the data that will be used to answer the research question.
 
List of eligible PCI-RR-friendly journals:

 

• Cortex
• In&Vertebrates
• Peer Community Journal
• PeerJ
• Royal Society Open Science
• Studia Psychologica

 
References

Carneiro, F., Hazelton, J. L., Campos, C., Ibáñez, A., & Ferreira-Santos, F. (2024). Allostatic interoception in frontotemporal dementia: a scoping review protocol. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/skebz