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Title *

Investigating the impact of vascular risk factors on the progression of white matter lesionsuse asterix (*) to get italics

Authors *

Frauke Beyer,Laurenz Lammer, Markus Loeffler, Steffi Riedel-Heller, Arno Villringer, Veronica WittePlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2023

Picture

Abstract *

<p>Cerebral small vessel disease (cSVD) is a major brain pathology contributing to cognitive decline and dementia. Vascular risk factors have been associated with imaging markers of cSVD such as white matter lesions, yet longitudinal studies have not comprehensively assessed these effects for abdominal obesity or reported sex-specific effects. In this pre-registered analysis of a longitudinal population-based neuroimaging cohort, we aim to fill this gap by providing a comprehensive analysis of the association of blood pressure on the progression of white matter lesions in sex-stratified analyses. We will also investigate the link of white matter lesion progression and cognitive performance. Further, we will explore the contribution of baseline abdominal obesity to white matter lesion progression and explore whether the vascular risk factors are associated with specific locations of white matter lesions.</p>

Indicate the full web address (DOI or URL) giving public access to these data (if you have any problems with the deposit of your data, please contact contact@rr.peercommunityin.org). *

You should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://

Indicate the full web address (DOI or URL) giving public access to these scripts (if you have any problems with the deposit of your scripts, please contact contact@rr.peercommunityin.org). *

You should fill this box only if you chose 'Scripts were used to obtain or analyze the results'. URL must start with http:// or https://

Indicate the full web address (DOI, SWHID or URL) giving public access to these codes (if you have any problems with the deposit of your codes, please contact contact@rr.peercommunityin.org). *

You should fill this box only if you chose 'Codes have been used in this study'. URL must start with http:// or https://

Keywords (optional)

MRI, small vessel disease, white matter lesions, healthy aging, prevention, obesity, hypertension, vascular risk

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Life Sciences

Suggested reviewers - Suggest up to 10 reviewers (provide names and Email addresses). (Optional)

e.g. John Doe john@doe.com

No need for them to be recommenders of PCI Registered Reports. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct

Opposed reviewers - Suggest up to 5 people not to invite as reviewers. (Optional)

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Submission date

2022-10-07 13:44:11

Recommender

Chris Chambers

Reviewers

Isabel Garcia Garcia, Max Elliott

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