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736

Title *

Allostatic Interoception in Frontotemporal Dementia: A Scoping Review Protocoluse asterix (*) to get italics

Authors *

Fábio Carneiro, Jessica L. Hazelton, Carlos Campos, Agustín Ibáñez, Fernando Ferreira-SantosPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2024

Picture

Abstract *

<p>Frontotemporal dementia (FTD) encompasses a spectrum of disorders characterized by distinct behavioral, cognitive, and motor symptoms. Deficits in interoception and allostasis have garnered attention, considering the involvement of the allostatic-interoceptive network in FTD, their contribution to canonical social cognitive and affective deficits, and the identification of whole-body biomarkers related to autonomic and allostatic processes. Traditionally, interoception has been defined as the perception of visceral signals, yet contemporary understandings broaden this definition to encompass both the representation and regulation of the physiological state across bodily tissues. Consequently, interoceptive deficits in FTD extend beyond classical viscerosensory paradigms to include pain, temperature, autonomic, metabolic, immune, and neuroendocrine phenomena. Allostasis involves the prospective regulation of energy balance, as well as the anticipation and adaptive response to homeostatic challenges. These repeated challenges result in physiological consequences measurable by markers of allostatic load, spanning various bodily systems. Despite emerging evidence highlighting dysfunction in interoception and allostasis in FTD, the literature remains fragmented, lacking cohesive reviews addressing the diverse mechanisms comprehensively. Thus, this scoping review examines the reciprocal interaction between brain and bodily physiology (interoception) and the physiological responses to environmental demands (allostatic load) in FTD. Following the principles outlined in the PRISMA statement, we will systematically search and screen quantitative primary research studies on patients with FTD, utilizing interoceptive or allostatic metrics. By synthesizing the existing literature, we aim to identify active research areas, delineate primary deficits across physiological systems, uncover syndrome-specific patterns of dysfunction, and identify the most promising and understudied domains in this field.</p>

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Keywords (optional)

Interoception; Allostasis; Autonomic Nervous System; Frontotemporal Dementia; Frontotemporal Lobar Degeneration.

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Medical Sciences

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Submission date

2024-03-08 19:37:35

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Mateo Leganes-Fonteneau

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