Mind-wandering broadly refers to the phenomenon by which a person's thoughts are directed towards internally generated states as opposed to being directed towards those that are task-relevant. It has been proposed that mind-wandering and cognitive control are supported by overlapping neural systems. While neuroimaging work has implicated prefrontal cortex in both mind-wandering and cognitive control, studies testing its causal role using transcranial direct current stimulation (tDCS) have been inconclusive.

 

In this study, Rasmussen and colleagues will test whether the effects of prefrontal cortex tDCS on mind-wandering are mediated by dopaminergic availablility, which is known to be important for cognitive control. Using noninvasive brain stimuluation (prefrontal cortex tDCS vs sham) and a pharmacological intervention (levodopa vs. placebo), the authors will test for a causal role of both prefrontal cortex and dopamine availability in mind-wandering, and whether dopamine availability alters the effect of tDCS on mind-wandering.

 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).

 

URL to the preregistered Stage 1 protocol: https://osf.io/ujp7e
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. 
 
List of eligible PCI RR-friendly journals:
 

• Advances in Cognitive Psychology
• Brain and Neuroscience Advances
• Cortex
• Imaging Neuroscience
• NeuroImage: Reports
• Peer Community Journal
• PeerJ
• Psychology of Consciousness: Theory, Research, and Practice
• Royal Society Open Science
• Studia Psychologica

 

 

1. Rasmussen, T., Dux, P. E. & Filmer, H. (2024). On the neural substrates of mind wandering and dynamic thought: A drug and brain stimulation study. In principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/ujp7e