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Latest recommendations
| Id | Title | Authors▲ | Abstract | Picture | Thematic fields | Recommender | Reviewers | Submission date | |
|---|---|---|---|---|---|---|---|---|---|
18 May 2023
STAGE 1
A multilab investigation into the N2pc as an indicator of attentional selectivity: Direct replication of Eimer (1996)Is the N2pc a correlate of attentional selection? An #EEGManyLabs multi-lab registered replication of Eimer (1996)Recommended by Maxine Sherman based on reviews by Reny Baykova and Clayton Hickey
The N2pc is a lateralised ERP component that is often interpreted as a marker of attentional allocation, so much so that it is frequently used a tool in the attention literature for inferring that a stimulus was attentionally processed. This interpretation of N2pc can be traced back to the seminal work of Eimer (1996), which has been conceptually replicated many times but has never been replicated directly.
This registered direct replication by Constant et al. (2023) forms part of a larger series of large-scale, multi-lab replications of highly influential EEG papers by the #EEGManyLabs project (Pavlov et al., 2021). Seven labs (with the potential for more to sign up later), will conduct high-powered replications of the critical Experiment 2 of Eimer (1996), where in the crucial conditions, participants discriminate a target letter (M vs W) or colour (blue vs green) in the presence of a distractor. Using four preprocessing pipelines, including the original, the authors will test whether the N2pc is observed over parieto-occipital electrodes contralateral to target presentation.
The Stage 1 manuscript was evaluated over one round of in-depth review and one additional round of minor corrections. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/dw68r
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA (so-called “primary RR”)
List of eligible PCI RR-friendly journals:
References
1. Constant, M., Mandal, A., Asanowicz, D., Yamaguchi, M., Gillmeister, H., Kerzel, D., Luque, D., Pesciarelli, F., Fehr, T., Mushtaq, F., Pavlov, Y. G. & Liesefeld, H. R. (2023). A multilab investigation into the N2pc as an indicator of attentional selectivity: Direct replication of Eimer (1996), in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/dw68r
2. Eimer, M. (1996). The N2pc component as an indicator of attentional selectivity. Electroencephalography and Clinical Neurophysiology, 99, 225-234. https://doi.org/10.1016/0013-4694(96)95711-9
3. Pavlov, Y. G., Adamian, N., Appelhoff, S., Arvaneh, M., Benwell, C. S., Beste, C., ... & Mushtaq, F. (2021). #EEGManyLabs: Investigating the replicability of influential EEG experiments. Cortex, 144, 213-229. https://doi.org/10.1016/j.cortex.2021.03.013
| A multilab investigation into the N2pc as an indicator of attentional selectivity: Direct replication of Eimer (1996) | Martin Constant, Ananya Mandal, Dariusz Asanowicz, Motonori Yamaguchi, Helge Gillmeister, Dirk Kerzel, David Luque, Francesca Pesciarelli, Thorsten Fehr, Faisal Mushtaq, Yuri G. Pavlov, Heinrich R. Liesefeld | <p>The N2pc is widely employed as an electrophysiological marker of an attention allocation. This interpretation was in no small part driven by the observation of an N2pc elicited by an isolated relevant target object, which was reported as Experi... | Life Sciences, Social sciences | Maxine Sherman | 2023-02-24 11:41:52 | |||
21 Apr 2024
STAGE 1
Mechanisms of secularization: Testing between three causal pathwaysUnderstanding links between secularization, rationalisation and insecurityRecommended by Adrien Fillon based on reviews by Chris Chambers and 1 anonymous reviewer
What relationship can be expected between secularization, rationalisation and insecurity? While some authors argue that rationalisation reduces the willingness to belong to religious groups, others have suggested that insecurity increases this need to belong to religious groups.
In the current study, Lang and Chvaja (2024) will adjudicate between these two possibilities using an economics game in participants from two countries: US and Poland. The central question posed by the authors is whether cooperative insecurity increases the probability of joining a religious normative group. They will test the relationship between an environment (secure and insecure) and institution (which related to the norm context: religious and secular) on the probability of choosing the normative group in an experimental setting. Therefore, the study will be a quantitative analysis.
The authors included an adequate power analysis, alternatives for non-supported hypotheses, and filtering to ensure a high quality of data collection. They also undertook a pilot study to ensure the quality of the procedure and sensitivity of the analyses.
The Stage 1 manuscript was evaluated over one round of in-depth review. Based on detailed responses to reviewers’ and the recommender’s comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.
URL to the preregistered Stage 1 protocol: https://osf.io/yzgek
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals:
References 1.Lang, M. & Chvaja, R. (2024). Mechanisms of secularization: Testing between the rationalization and existential insecurity theories. In principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/yzgek
| Mechanisms of secularization: Testing between three causal pathways | Martin Lang, Radim Chvaja | <p>The study tests two competing explanations of the secularization process related to rationalizing worldviews and decreasing existential insecurity. While the former explanation argues that people are unwilling to join religious groups because o... | Social sciences | Adrien Fillon | 2023-11-22 11:17:30 | |||
14 Feb 2022
STAGE 1
Minimal mindfulness of the world as an active control for a full mindfulness of mental states intervention: A Registered Report and Pilot studyTesting the metacognitive basis and benefits of mindfulness trainingRecommended by Robert McIntosh based on reviews by Chris Noone and Julieta Galante
Mindfulness is inherently metacognitive in that it requires monitoring of one’s own thoughts and attention in order to remain on task. Mindfulness practice is especially metacognitive when focused on internal mental states, rather than on the external world. This Registered Report will compare remote training in mindfulness of mental states with remote training in mindfulness of the world, and a wait list control, to test the idea that mindfulness of mental states has an additional metacognitive component, and that this has benefits for (self-reported) mental health. A comparison of participant expectancies between mindfulness conditions will be used to establish whether mindfulness of the world can be considered a true ‘active control’ condition. Additional comparisons will test whether this mindfulness control has benefits over the (inactive) waiting list condition. The study plan is informed by prior research, including pilot data presented in the Stage 1 report, and a sample of up to 300 participants will be tested. The Stage 1 plan has been evaluated through two round of signed external review, and a further two rounds of minor revisions, with the recommender obtaining specialist advice on key points from a relevant external expert. The recommender has judged that the manuscript now meets all Stage 1 criteria, and has awarded In Principle Acceptance (IPA). URL to the preregistered Stage 1 protocol: https://osf.io/tx54k Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References Lovell, M., & Dienes, Z. (2022). Minimal mindfulness of the world as an active control for a full mindfulness of mental states intervention: A Registered Report and Pilot study, in principle acceptance of version 4 by Peer Community in Registered Reports. https://osf.io/tx54k | Minimal mindfulness of the world as an active control for a full mindfulness of mental states intervention: A Registered Report and Pilot study | Max Lovell, Zoltan Dienes | <p>Mindfulness is a continual renewal of non-elaborative attention on an object of focus, without clinging or aversion, and with equanimity. As this requires the capacity to monitor and control the extent to which one is on task, it is a metacogni... | Social sciences | Robert McIntosh | 2021-06-21 16:49:39 | |||
09 Jun 2022
STAGE 1
Revisiting diversification bias and partition dependence: Replication and extensions of Fox, Ratner, and Lieb (2005) Studies 1, 2, and 5Testing the replicability of diversification bias and partition dependenceRecommended by Chris Chambers based on reviews by Craig Fox and Leo Cohen
When offered a range of options and asked to make multiple selections, how do people choose? Over the last 30 years, a key finding to emerge from behavioural economics is that people distribute their choices more evenly than would be considered optimal – a phenomenon termed “diversification bias” or the “diversification heuristic” (Read & Loewenstein, 1995). For example, when filling a plate from a buffet, you might be inclined to choose a relatively even amount of everything on offer, even when you prefer some foods over others. Similarly, when allocating savings among different investment options, people are prone to spreading their money more evenly than would maximise utility.
In an influential study, Fox et al. (2005) found that diversification bias can be shaped by so-called “partition dependence” – the tendency to allocate resources differently across options depending on how they are subjectively grouped. Such groupings could be arbitrary; so, for example, to return to the buffet example, people might diversify across high-level categories such as cooked and uncooked, savoury and sweet, or surf and turf, and then diversify across the options within those categories. The nature of level of these subjective (and potentially arbitrary) categorisations can strongly influence the final allocation of resources. Diversification bias and partition dependence have important implications for basic theory in judgment and decision-making as well as applications in behavioral economics and finance.
In the current study, Li and Feldman (2022) propose to replicate Studies 1, 2 and 5 from Fox et al. (2002) in a large online sample. In particular, they plan to ask how partitioning influences the allocation of choices between options, and the extent to which partition dependence is reduced in people with greater relevant expertise. The authors also propose extending the original study to explore individual differences in the desire for choice diversity as predictors of partition dependence.
The Stage 1 manuscript was evaluated over one round of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/bx8vq Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals: References 1. Read, D., & Loewenstein, G. (1995). Diversification bias: Explaining the discrepancy in variety seeking between combined and separated choices. Journal of Experimental Psychology: Applied, 1, 34-49. https://doi.org/10.1037/1076-898X.1.1.34
2. Fox, C. R., Ratner, R. K., & Lieb, D. S. (2005). How subjective grouping of options influences choice and allocation: Diversification bias and the phenomenon of partition dependence. Journal of Experimental Psychology: General, 134, 538-551. https://doi.org/10.1037/0096-3445.134.4.538
3. Li, M. Y. & Feldman, G. (2022). Revisiting diversification bias and partition dependence: Replication and extension of Fox, Ratner, and Lieb (2005) Studies 1, 2, and 5, in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/bx8vq | Revisiting diversification bias and partition dependence: Replication and extensions of Fox, Ratner, and Lieb (2005) Studies 1, 2, and 5 | Mei Yee (Alice) Li, Gilad Feldman | <p>This is a scheduled PCI-RR snap shot for a planned project: "Revisiting diversification bias and partition dependence: Replication and extensions of Fox, Ratner, and Lieb (2005) Studies 1, 2, and 5 "</p> | Social sciences | Chris Chambers | Craig Fox, Leo Cohen | 2022-02-15 09:57:51 | ||
17 May 2022
STAGE 1
Revisiting mental accounting classic paradigms: Replication of Thaler (1999) and an extension examining impulsivityMental accounting under the microscopeRecommended by Chris Chambers based on reviews by Barnabas Szaszi and Féidhlim McGowan
In recent years, the study of mental accounting – the thought processes by which people informally record, categorise, and evaluate the costs and benefits of their financial transactions – has been an active research area, drawing attention to a range of biases and distortions that deviate from optimal economic decision-making (Zhang & Sussman, 2018). Although the term “mental accounting” is a relatively recent construction (Thaler, 1999), it stems from a longer history of behavioural economic research on value functions, decision frames, risk-taking, and related concepts.
In the current study, Li and Feldman propose to replicate 17 influential mental accounting problems (or tasks) reviewed by Thaler (1999) in a large online sample. The authors also propose several extensions examining the effects of sunk costs and expenses framing.
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/d6cjk
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals:
References
1. Zhang, C. Y., & Sussman, A. B. (2018). Perspectives on mental accounting: An exploration of budgeting and investing. Financial Planning Review, 1, e1011. https://doi.org/10.1002/cfp2.1011
2. Thaler, R. H. (1999). Mental accounting matters. Journal of Behavioral Decision Making, 12, 183-206. https://doi.org/10.1002/(SICI)1099-0771(199909)12:3%3C183::AID-BDM318%3E3.0.CO;2-F
3. Li, M. & Feldman, G. (2022). Revisiting mental accounting classic paradigms: Replication of the problems reviewed in Thaler (1999), in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/d6cjk
| Revisiting mental accounting classic paradigms: Replication of Thaler (1999) and an extension examining impulsivity | Mengfei Li; Gilad Feldman | <p>This is a scheduled PCI-RR snap shot for a planned project: "Revisiting mental accounting classic paradigms: Replication of Thaler (1999) and an extension examining impulsivity"</p> | Social sciences | Chris Chambers | 2022-01-31 10:18:38 | |||
21 Oct 2022
STAGE 1
Replicating the facilitatory effects of transcranial random noise stimulation on motion processing: A registered reportTesting the facilitatory effect of high-frequency transcranial random noise stimulation through enhancement of global motion processingRecommended by Robert McIntosh based on reviews by Sam Westwood and Filippo Ghin
High frequency transcranial random noise stimulation (hf-tRNS) is a relatively novel form of non-invasive brain stimulation, thought to enhance neural excitability and facilitate processing in targeted brain areas. The evidence for the efficacy of hf-tRNS is mixed, so a high-powered test of the proposed facilitatory effects would be of value to the field. This Registered Report will target the human middle temporal complex (hMT+), an area with a well-established critical role in global motion processing. The protocol is adapted from a study by Ghin and colleagues (2018) but focusing on a sub-set of the original experimental conditions and using a fully within-subjects design (n=42). Global motion processing will be operationalised in terms of the coherence threshold for identification of the dominant direction of random-dot motion. The experiment will test the predicted facilitation of contralateral motion processing (reduced coherence threshold) during hf-tRNS to the left hMT+. The specificity of this effect will be tested by comparison to a sham stimulation control condition and an active stimulation control condition (left forehead). By targeting a brain area with a well-established critical role in behaviour, this study will provide important information about the replicability and specificity of the facilitatory effects of hf-tRNS.
Following two rounds of in-depth review, the recommender judged that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/bce7u Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References
1. Ghin, F., Pavan, A., Contillo, A., & Mather, G. (2018). The effects of high-frequency transcranial random noise stimulation (hf-tRNS) on global motion processing: an equivalent noise approach. Brain Stimulation, 11, 1263–75.
2. Caroll, M. B., Edwards, G. & Baker, C. I. (2022). Replicating the facilitatory effects of transcranial random noise stimulation on motion processing: A registered report, in principle acceptance of Version 7 by Peer Community in Registered Reports. https://osf.io/bce7u
| Replicating the facilitatory effects of transcranial random noise stimulation on motion processing: A registered report | Mica B. Carroll*, Grace Edwards*, Chris I. Baker | <p>Non-invasive brain stimulation (NIBS) techniques have the potential to demonstrate the causal impact of targeted brain regions on specific behaviors, and to regulate or facilitate behavior in clinical applications. Transcranial random noise sti... | Life Sciences | Robert McIntosh | 2022-06-02 21:25:02 | |||
03 May 2022
STAGE 1
Revisiting the links between numeracy and decision making: Replication of Peters et al. (2006) with an extension examining confidenceAssessing the replicability of specific links between numeracy and decision-makingRecommended by Chris Chambers based on reviews by Daniel Ansari and Elena Rusconi
Numeracy – the ability to understand and work with numbers – is associated with a wide range of social and health-related outcomes, including socioeconomic status, employment, literacy, reasoning, and life satisfaction. A substantial body of evidence has also shown links between numeracy and decision-making, prompting the question of how it relates to finer-grained measures of reasoning, judgment and affect/emotion.
In the current study, Zhu and Feldman propose to replicate four influential experiments from a study by Peters et al. (2006), which demonstrated links between numeracy and performance on a variety of decision-making tasks, including attribute framing, frequency-percentage framing, susceptibility to affective influences, and various cognitive biases. The authors also propose several extended questions, including refinements of the original hypotheses and an examination of the relationship between numeracy and confidence in numeric judgments (subjective numeracy).
The Stage 1 manuscript was evaluated over one round of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/r73fb
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals:
References
1. Zhu, M. & Feldman, G. (2022). Revisiting the links between numeracy and decision making: Replication of Peters et al. (2006) with an extension examining confidence, in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/r73fb
2. Peters, E., Västfjäll, D., Slovic, P., Mertz, C. K., Mazzocco, K., & Dickert, S. (2006). Numeracy and decision making. Psychological Science, 17, 407-413. https://doi.org/10.1111%2Fj.1467-9280.2006.01720.x
| Revisiting the links between numeracy and decision making: Replication of Peters et al. (2006) with an extension examining confidence | Minrui Zhu, Gilad Feldman | <p>This is a scheduled PCI-RR snap shot for a planned project: "Revisiting the links between numeracy and decision making: Replication of Peters et al. (2006) with an extension examining confidence"</p> | Social sciences | Chris Chambers | 2022-01-31 10:27:58 | |||
Revisiting the links between numeracy and decision making: Replication Registered Report of Peters et al. (2006) with an extension examining confidenceAssessing the replicability of specific links between numeracy and decision-makingRecommended by Chris Chambers based on reviews by Elena Rusconi
Numeracy – the ability to understand and work with numbers – is associated with a wide range of social and health-related outcomes, including socioeconomic status, employment, literacy, reasoning, and life satisfaction. A substantial body of evidence has also shown links between numeracy and decision-making, prompting the question of how it relates to finer-grained measures of reasoning, judgment and affect/emotion.
In the current study, Zhu and Feldman repeated four influential experiments from a study by Peters et al. (2006), which reported links between numeracy and performance on a variety of decision-making tasks, including attribute framing, frequency-percentage framing, susceptibility to affective influences, and various cognitive biases. The authors also explored several extended questions, including refinements of the original hypotheses and an examination of the relationship between numeracy and confidence in numeric judgments (subjective numeracy).
The results broadly constitute a successful replication, with higher numeracy associated with weaker attribute framing and susceptibility to bias. The relationship between numeracy and the frequency-percentage framing effect – that is, the change in decision-making when numbers are presented as frequencies (e.g. 5 out of 100) rather than percentages (e.g. 5%) – was inconclusive for the main analysis that treated numeracy as a categorical variable (low vs. high); however the link emerged reliably in exploratory analyses that considered numeracy as a continuous variable. The outcomes of the extended analyses were mixed, revealing evidence for a potentially weak relationship between numeracy and confidence.
The Stage 2 manuscript was evaluated over one round of in-depth review. Based on detailed responses to the reviewer's comments, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/r73fb
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA.
List of eligible PCI RR-friendly journals:
References
1. Zhu, M. & Feldman, G. (2022). Revisiting the links between numeracy and decision making: Replication Registered Report of Peters et al. (2006) with an extension examining confidence. Acceptance of Version 5 by Peer Community in Registered Reports. https://osf.io/62wqb
2. Peters, E., Västfjäll, D., Slovic, P., Mertz, C. K., Mazzocco, K., & Dickert, S. (2006). Numeracy and decision making. Psychological Science, 17, 407-413. https://doi.org/10.1111%2Fj.1467-9280.2006.01720.x
| Revisiting the links between numeracy and decision making: Replication Registered Report of Peters et al. (2006) with an extension examining confidence | Minrui Zhu, Gilad Feldman | <p>Numeracy is individuals’ capacity to understand and process basic probability and numerical information required to make decisions. We conducted a Replication Registered Report of Peters et al. (2006) examining numeracy as a predictor of positi... | Social sciences | Chris Chambers | 2023-01-16 10:34:09 | |||
Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgeryIs childhood adversity associated with a heightened response to opioids?Recommended by Chris Chambers based on reviews by Zoltan Dienes, Yuki Yamada and 1 anonymous reviewer
A convergence of evidence suggests that early life adversity may cause dysfunction in opioid-sensitive reward systems. Childhood adversity is associated with opioid use, potentially by altering reward and motivation networks, and experimental models in animals have found that early life adversity increases and consolidates opioid seeking behaviours. Further, in a recent controlled experiment, Carlyle et al. (2021) found that opioid administration produced stronger positive responses, and weaker negative responses, in adults with a history of childhood abuse and neglect.
In the current study, Carlyle et al. (2023) tested the generalisability of these previous findings in a pre-operative clinical setting. Using partially observed data from an existing cohort study (N=155), the authors asked whether patients with greater experience of childhood trauma in turn exhibit a larger mood boost and express greater subjective pleasure following opioid administration.
In contrast to previous findings, the results did not support the hypotheses that more experiences of childhood adversity would heighten ratings of drug liking and feeling good following opioid administration. Regression analyses instead revealed a statistically significant negative association between childhood adversity and post-opioid liking and no significant relationship with feeling good. The authors suggest that the discrepancy between the current and previous results may be due to stress related to the pre-surgical setting, the brief duration of drug exposure, and the relatively limited levels of high childhood adversity in the study sample. Nevertheless, these findings cast some doubt on the theory that adversity elevates risk of opioid addiction by altering sensitivity to subjectively pleasurable effects.
Following one round of in-depth review, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/7ymts Level of bias control achieved: Level 2. At least some data/evidence that was used to answer the research question had been accessed and partially observed by the authors prior to IPA, but the authors certify that they had not yet observed the key variables within the data that were used to answer the research question AND they took additional steps to maximise bias control and rigour. List of eligible PCI RR-friendly journals:
References
1. Carlyle M., Broomby R., Simpson G., Hannon R., Fawaz L., Mollaahmetoglu O.M., Drain, J., Mostazir, M., & Morgan C. (2021). A randomised, double‐blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine. Addiction Biology, 26(6):e13047. https://doi.org/10.1111/adb.13047
2. Carlyle, M., Kvande, M., Meier, I. M., Trøstheim, M., Buen, K., Jensen, E. N., Ernst, G. & Leknes, S. & Eikemo, M. (2023). Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery, acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/9kt3a?view_only=4238d2ee3d654c4f908a94efea82a027
| Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery | Molly Carlyle1*, Malin Kvande*, Isabell M. Meier, Martin Trøstheim, Kaja Buen, Eira Nordeng Jensen, Gernot Ernst, Siri Leknes, Marie Eikemo (*denotes equal contribution) | <p><strong>Introduction</strong>: Opioid analgesic treatment during surgery entails risk of persistent use. Experiences of childhood adversity have been shown to increase opioid reward in preclinical models, a finding recently extended to healthy ... | Medical Sciences, Social sciences | Chris Chambers | 2023-02-02 08:29:18 | |||
24 Oct 2022
STAGE 1
Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgeryIs childhood adversity associated with a heightened response to opioids?Recommended by Chris Chambers based on reviews by Zoltan Dienes, Yuki Yamada and 1 anonymous reviewer
A convergence of evidence suggests that early life adversity may cause dysfunction in opioid-sensitive reward systems. Childhood adversity is associated with opioid use, potentially by altering reward and motivation networks, and experimental models in animals have found that early life adversity increases and consolidates opioid seeking behaviours. Further, in a recent controlled experiment, Carlyle et al. (2021) found that opioid administration produced stronger positive responses, and weaker negative responses, in adults with a history of childhood abuse and neglect.
In the current study, Carlyle et al. seek to test the generalisability of these previous findings in a pre-operative clinical setting. Using partially observed data from an existing cohort study (N=155), the authors will test whether patients with greater experience of childhood trauma in turn exhibit a larger mood boost and express greater subjective pleasure following opioid administration. Although not a randomised experimental design, this study provides the opportunity to examine the relationship between opioid response and history of childhood adversity in a naturalistic setting, and thus has the potential to either support or cast doubt on the theory that adversity elevates risk of opioid addiction by altering sensitivity to subjectively pleasurable effects.
Following three rounds of in-depth review, the recommender judged that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/7ymts Level of bias control achieved: Level 2. At least some data/evidence that will be used to answer the research question has been accessed and partially observed by the authors, but the authors certify that they have not yet observed the key variables within the data that will be used to answer the research question AND they have taken additional steps to maximise bias control and rigour. List of eligible PCI RR-friendly journals:
References
1. Carlyle M., Broomby R., Simpson G., Hannon R., Fawaz L., Mollaahmetoglu O.M., Drain, J., Mostazir, M., & Morgan C. (2021). A randomised, double‐blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine. Addiction Biology, 26(6):e13047.
2. Carlyle, M., Kvande, M., Leknes, S., Meier, I., Buen, K., Jensen, E. N., Ernst, G. & Eikemo, M. (2022). Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery, in principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/7ymts
| Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery | Molly Carlyle*, Malin Kvande*, Siri Leknes, Isabell Meier, Kaja Buen, Eira Nordeng Jensen, Gernot Ernst, Marie Eikemo. *denotes equal contribution. | <p>PCI-RR Snapshot only</p> | Life Sciences, Medical Sciences, Social sciences | Chris Chambers | 2022-03-15 10:07:29 |
