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Latest recommendations
| Id | Title * ▲ | Authors * | Abstract * | Picture | Thematic fields * | Recommender | Reviewers | Submission date | |
|---|---|---|---|---|---|---|---|---|---|
02 Jun 2024
STAGE 1
Mapping Cross-Disciplinary Perspectives on Responsible Conduct of Research: A Delphi StudyCapturing Perspectives on Responsible Research Practice: A Delphi StudyRecommended by Charlotte Pennington and Maanasa Raghavan based on reviews by Moin Syed, Veli-Matti Karhulahti, Thomas Evans, Priya Silverstein and Sean Grant
The responsible conduct of research (RCR) is crucial for the health of the research ecosystem: high quality research should lead to more credible findings and increase public trust. However, the dimensions and responsibilities that make up RCR differ across disciplines, who together can learn from one another to ensure rigorous, transparent, and reliable research and foster healthier research culture.
Bridging this gap, in their Stage 1 Registered Report, Field and colleagues (2024) outline their plans for a large-scale Delphi study to evaluate academics' perceived levels of importance of the most crucial elements of RCR and how these align and differ across disciplines. First, they plan to assemble a Delphi panel of RCR experts across multiple disciplines who will evaluate a list of RCR dimensions to suggest any additions. Then, these same panellists will judge each RCR dimension on its importance within their discipline of expertise, with iterative rounds of ratings until stability is reached. In this latter phase, the goal is to probe which items are more broadly appreciated by the sample (i.e., those that are perceived as a universally valuable RCR practice), versus which might be more discipline specific. The findings will present the median importance ratings and categories of response agreement across the entire panel and between different disciplines. Finally, to contextualise these findings, the team will analyse qualitative findings from open-ended text responses with a simple form of thematic analysis. From this, the team will develop a framework, using the identified RCR dimensions, that reflects the needs of the academic community.
By mapping a broader multidisciplinary perspective on RCR, this research will fill the gap between the two extremes that existing conceptualisations of RCR tend to fall under: high-level frameworks designed to be universally applicable across all disciplines (e.g., the Singapore Statement on Research Integrity) and prescriptive guides tailored to the practical instruction of researchers within a specific discipline or field (e.g., RCR training designed for members of a university department). The hope is that this will stimulate a more nuanced understanding and discussion of cross-disciplinary conceptions of RCR.
Five expert reviewers with field expertise assessed the Stage 1 manuscript over two rounds of in-depth review. Based on detailed and informed responses to the reviewer’s comments, the recommenders judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/xmnu5 Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References
Field, S. M., Thompson, J., van Drimmelen, T., Ferrar, J., Penders, B., de Rijcke, S., & Munafò, M. R. (2024). Mapping Cross-Disciplinary Perspectives on Responsible Conduct of Research: A Delphi Study. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/xmnu5
| Mapping Cross-Disciplinary Perspectives on Responsible Conduct of Research: A Delphi Study | Sarahanne M. Field, Jackie Thompson, Tom van Drimmelen, Jennifer Ferrar, Bart Penders, Sarah de Rijcke, and Marcus R. Munafò | <p>Responsible conduct of research (RCR) is generally agreed to be a laudable goal. It promotes high quality research practices, which should lead to more credible findings, and instill confidence in the research community. However, it is as yet u... | Social sciences | Charlotte Pennington | 2023-05-19 15:27:54 | |||
21 Apr 2024
STAGE 1
Mechanisms of secularization: Testing between three causal pathwaysUnderstanding links between secularization, rationalisation and insecurityRecommended by Adrien Fillon based on reviews by Chris Chambers and 1 anonymous reviewer
What relationship can be expected between secularization, rationalisation and insecurity? While some authors argue that rationalisation reduces the willingness to belong to religious groups, others have suggested that insecurity increases this need to belong to religious groups.
In the current study, Lang and Chvaja (2024) will adjudicate between these two possibilities using an economics game in participants from two countries: US and Poland. The central question posed by the authors is whether cooperative insecurity increases the probability of joining a religious normative group. They will test the relationship between an environment (secure and insecure) and institution (which related to the norm context: religious and secular) on the probability of choosing the normative group in an experimental setting. Therefore, the study will be a quantitative analysis.
The authors included an adequate power analysis, alternatives for non-supported hypotheses, and filtering to ensure a high quality of data collection. They also undertook a pilot study to ensure the quality of the procedure and sensitivity of the analyses.
The Stage 1 manuscript was evaluated over one round of in-depth review. Based on detailed responses to reviewers’ and the recommender’s comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.
URL to the preregistered Stage 1 protocol: https://osf.io/yzgek
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals:
References 1.Lang, M. & Chvaja, R. (2024). Mechanisms of secularization: Testing between the rationalization and existential insecurity theories. In principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/yzgek
| Mechanisms of secularization: Testing between three causal pathways | Martin Lang, Radim Chvaja | <p>The study tests two competing explanations of the secularization process related to rationalizing worldviews and decreasing existential insecurity. While the former explanation argues that people are unwilling to join religious groups because o... | Social sciences | Adrien Fillon | 2023-11-22 11:17:30 | |||
22 Oct 2023
STAGE 1
Michotte's research on perceptual impressions of causality: a pre-registered replication studyGaining confidence in Michotte’s classic studies on the perception of causalityRecommended by Moin Syed based on reviews by Maxine Sherman and 1 anonymous reviewer
Making causal judgements are part of everyday life, whether seeking to understand the action of complex humans or the relations between inanimate objects in our environments. Albert Michotte’s (1963) classic book, The perception of causality, contained an extensive report of experiments demonstrating not only that observers perceive causality of inanimate shapes, but do so in manifold ways, creating different “causal impressions.” This work has been highly influential across psychology and neuroscience.
In the current study, White (2023) proposes a series of experiments to replicate and extend Michotte’s work. Despite the fact that this research is foundational to current work on perception and understanding of causal relations, it has never been subjected to rigorous replication. Moreover, like many research studies from that era, Michotte was sparse on details about methodology and did not rely on statistical analysis. White has proposed an ambitious set of 14 experiments that directly replicate and, in some cases, extend Michotte’s experiments.
The Stage 1 manuscript was evaluated over three rounds of in-depth review, the first two rounds consisting of detailed comments from two reviewers and the third round consisting of a close read by the recommender. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and was therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/5jx8f
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI-RR-friendly journals:
References
1. Michotte, A. (1963). The perception of causality (T. R. Miles & E. Miles, trans.). London: Methuen. (English translation of Michotte, 1954).
2. White, P. A. (2023). Michotte's research on perceptual impressions of causality: A registered replication study. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/5jx8f
| Michotte's research on perceptual impressions of causality: a pre-registered replication study | Peter A. White | <p> Michotte (1946/1954/1963) showed that visual impressions of causality can occur in perception of simple animations of moving geometrical objects. In the launching effect, one object is perceived as maki... | Life Sciences, Social sciences | Moin Syed | 2023-05-03 13:04:00 | |||
14 Feb 2022
STAGE 1
Minimal mindfulness of the world as an active control for a full mindfulness of mental states intervention: A Registered Report and Pilot studyTesting the metacognitive basis and benefits of mindfulness trainingRecommended by Robert McIntosh based on reviews by Chris Noone and Julieta Galante
Mindfulness is inherently metacognitive in that it requires monitoring of one’s own thoughts and attention in order to remain on task. Mindfulness practice is especially metacognitive when focused on internal mental states, rather than on the external world. This Registered Report will compare remote training in mindfulness of mental states with remote training in mindfulness of the world, and a wait list control, to test the idea that mindfulness of mental states has an additional metacognitive component, and that this has benefits for (self-reported) mental health. A comparison of participant expectancies between mindfulness conditions will be used to establish whether mindfulness of the world can be considered a true ‘active control’ condition. Additional comparisons will test whether this mindfulness control has benefits over the (inactive) waiting list condition. The study plan is informed by prior research, including pilot data presented in the Stage 1 report, and a sample of up to 300 participants will be tested. The Stage 1 plan has been evaluated through two round of signed external review, and a further two rounds of minor revisions, with the recommender obtaining specialist advice on key points from a relevant external expert. The recommender has judged that the manuscript now meets all Stage 1 criteria, and has awarded In Principle Acceptance (IPA). URL to the preregistered Stage 1 protocol: https://osf.io/tx54k Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References Lovell, M., & Dienes, Z. (2022). Minimal mindfulness of the world as an active control for a full mindfulness of mental states intervention: A Registered Report and Pilot study, in principle acceptance of version 4 by Peer Community in Registered Reports. https://osf.io/tx54k | Minimal mindfulness of the world as an active control for a full mindfulness of mental states intervention: A Registered Report and Pilot study | Max Lovell, Zoltan Dienes | <p>Mindfulness is a continual renewal of non-elaborative attention on an object of focus, without clinging or aversion, and with equanimity. As this requires the capacity to monitor and control the extent to which one is on task, it is a metacogni... | Social sciences | Robert McIntosh | 2021-06-21 16:49:39 | |||
13 Jul 2023
STAGE 1
Modulatory effects of instructions on extinction efficacy in appetitive and aversive learning: A registered reportNeurocognitive insights on instructed extinction in the context of painRecommended by Chris Chambers based on reviews by Tom Beckers, Gaëtan Mertens and Karita Ojala
Rapid learning in response to pain is a crucial survival mechanism, relying on forming associations between cues in the environment and subsequent pain or injury. Existing evidence suggests that associations between conditioned stimuli (cues) and unconditioned aversive stimuli (such as pain) are learned faster than for appetitive stimuli that signal pain relief. In addition, when the link between a conditioned and unconditioned stimulus is broken (by unpairing them), the extinction of this learning effect is slower for aversive that appetitive stimuli, resulting in a flatter extinction slope. Understanding why extinction slopes are reduced for aversive stimuli is important for advancing theoretical models of learning, and for devising ways of increasing the slope (and thus facilitating extinction learning) could help develop more effective methods of pain relief, particularly in the treatment of chronic pain.
In the current programmatic submission, Busch et al. (2023) will undertake two Registered Reports to test whether a verbal instruction intervention that explicitly informs participants about contingency changes between conditioned and unconditioned stimuli facilitates extinction learning, especially for aversive (painful) stimuli, and how changes in extinction learning relate to neural biomarkers of functional connectivity. In the first Registered Report, they will initially seek to replicate previous findings including faster acquisition of aversive than appetitive conditioned stimuli as well as incomplete extinction of aversive conditioned stimuli without verbal instruction. They will then test how the instruction intervention alters extinction slopes and the completeness of extinction for appetitive and aversive stimuli, using a range of behavioral measures (expectancy and valence ratings) and physiological measures (pupillometry, skin conductance responses). To shed light on the neural correlates of these processes, in the second Registered Report the authors will use functional magnetic resonance imaging (fMRI) to ask firstly how acquisition and extinction of aversive and appetitive conditioned responses are related to resting state brain connectivity within a network that includes ventromedial prefrontal cortex, amygdala, and striatum, and secondly, whether the effectiveness of instruction on extinction learning is associated with differences in resting state connectivity across this network.
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/cj75p (under temporary private embargo)
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References
1. Busch, L., Wiech, K., Gamer, M., Knicses, B., Spisak, T., Schmidt, K., & Bingel, U. (2023). Modulatory effects of instructions on extinction efficacy in appetitive and aversive learning: A registered report. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/cj75p
| Modulatory effects of instructions on extinction efficacy in appetitive and aversive learning: A registered report | Lea Busch, Katja Wiech, Matthias Gamer, Balint Kincses, Tamas Spisak, Katharina Schmidt, Ulrike Bingel | <p>In the context of pain, extinction learning has been shown to be slower or incomplete for aversive compared to appetitive cues (i.e., cues signaling pain exacerbation and pain relief, respectively), potentially due to their higher biological re... | Medical Sciences | Chris Chambers | 2022-10-15 19:45:48 | |||
08 Feb 2022
STAGE 1
Motivational Control of Habits: A Preregistered fMRI StudyPutting the Expected Value of Control (EVC) theory to the test in explaining habitual actionRecommended by Chris Chambers based on reviews by 2 anonymous reviewers
What are the neurocognitive mechanisms underlying the formation of habits? In this Stage 1 Registered Report, Eder and colleagues propose an fMRI study to test a key prediction of the Expected Value of Control (EVC) theory: that the dorsal anterior cingulate cortex (dACC) – a region heavily implicated in reward processing, cognitive control, and action selection – will show increased activity during the presentation of Pavlovian cues that are associated with devalued outcomes. In combination with a series of behavioural positive controls, this observation would provide evidence in support of EVC theory, whereas failure to do so may support alternative accounts that propose independence of habits from the representations of outcomes. The Stage 1 manuscript was evaluated over two rounds of in-depth specialist review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA). This IPA recommendation was issued on 8 Feb 2022, and was initially provisional due to lack of ethics approval. The recommendation was then updated and confirmed on 21 Feb 2022 following confirmation that ethics approval had been granted. URL to the preregistered Stage 1 protocol: https://osf.io/k8ygb Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals: References Eder, A. B., Dignath, D. & Gamer, M. (2022). Motivational Control of Habits: A Preregistered fMRI Study. Stage 1 preregistration, in principle acceptance of version 3 by Peer Community in Registered Reports. https://osf.io/k8ygb | Motivational Control of Habits: A Preregistered fMRI Study | Andreas B. Eder, David Dignath, Matthias Gamer | <p>Habitual action is typically distinguished from goal-directed action by its insensitivity to changes in the reward value. There is an ongoing discussion whether this insensitivity is an intrinsic design feature of habits or, rather, a function ... | Social sciences | Chris Chambers | 2021-10-05 11:51:08 | |||
17 Jun 2024
STAGE 1
Neophobia across social contexts in juvenile Herring gullsDoes social context influence neophobia in juvenile herring gulls (Larus argentatus)?Recommended by Ljerka Ostojic based on reviews by 2 anonymous reviewers
Many animals are increasingly reliant on living close or in urban environments. For them, neophobia – a trait that denotes the fearfulness of novelty (Mettke-Hoffmann, 2022) – may influence how well the species but also individuals of the same species adjust to the (human-induced) changes that characterise these environments (Lowry et al., 2013).
Typically, neophobia in non-human animals is assessed through behavioural tests, most often by measuring the time it takes an individual to approach a novel object or food that is positioned next to a novel object. Increasingly, resarchers are acknowledging that the social context may influence the behaviour of individuals in such situations, and several hypotheses have been proposed to explain a potential influence of social context on neophobic responses.
In the current study, Allaert et al. (2024) will use a within-subject design to test three hypotheses with juvenile herring gulls (Larus argentatus): 1) the risk dilution hypothesis, accoding to which gulls will exhibit smaller neophobic responses when tested in a group than when tested alone, 2) the negotiation hypothesis, according to which gulls will exhibit stronger neophobic responses when tested in a group than when tested alone, and 3) the social conformity hypothesis, according to which those more neophobic individuals will show a smaller neohobic response when tested in a group than when tested alone while less neophobic individuals will exhibit the opposite pattern.
The Stage 1 manuscript was evaluated by two reviewers over two rounds of revisions. During the revisions, the authors clarified the conceptual arguments of the manuscript (including why juveniles are being tested), and edited the methods, including timing of testing, adjustments to the way that the experimental and control conditions will be run, how the planned sample size will be ensured given that at the time of testing, some chicks may be of a different species (this will become evident later on), how relatedness between the chicks will be dealt with, as well as how the behavioural coding will be conducted. Thus, the recommender judged that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/u4b7q
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References
1. Mettke-Hofmann, C. (2022). Neophobia. In: Vonk, J., Shackelford, T.K. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. https://doi.org/10.1007/978-3-319-55065-7_908
2. Lowry, H., Lill, A., & Wong, B. B. (2013). Behavioural responses of wildlife to urban environments. Biological Reviews, 88, 537-549. https://doi.org/10.1111/brv.12012
3. Allaert, R., Knoch, S., Braem, S., Debeer, D, Martel, A., Müller, W., Stienen E., Lens, L., & Verbruggen. F. (2024) In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/u4b7q
| Neophobia across social contexts in juvenile Herring gulls | Reinoud Allaert, Sophia Knoch, An Martel, Wendt Müller, Eric Stienen, Luc Lens, Frederick Verbruggen | <p>Neophobia, the fear or avoidance of the unfamiliar, can have significant fitness consequences. It is typically assessed by exposing individuals to unfamiliar objects when they are alone, but in social species the presence of conspecifics can in... | Life Sciences | Ljerka Ostojic | 2024-02-16 14:50:02 | |||
16 Mar 2022
STAGE 1
Neuroanatomical Correlates of System-justifying Ideologies: A Pre-registered Voxel-based Morphometry Study on Right-Wing Authoritarianism and Social Dominance OrientationWhat are the neuranatomical correlates of system-justifying ideologies?Recommended by Chris Chambers based on reviews by Bonni Crawford and 2 anonymous reviewers
Under the tenets of system justification theory, system-justifying ideologies are beliefs held by individuals to defend and justify the status quo, even when doing do perpetuates social inequalities (Jost and Hunyady, 2005). Two such well-studied ideologies to emerge from political science and social psychology are social dominance orientation (SDO) – the belief that some social groups are superior to others – and right wing authoritarianism (RWA) – the belief that people should follow conventional traditions and authorities, avoiding rebellious ideas. Although considered to be stable traits that may have a heritable basis, there has been little investigation of the neural correlates of SDO and RWA, and it remains unknown whether they are associated with common or distinct brain systems. In the current study, Balagtas et al propose a novel investigation of the neuroanatomical correlates of both SDO and RWA in a Chinese Singaporean sample using voxel-based morphometry. Based on previous research, the authors focus especially on relationships between SDO, RWA and the volume of the amygdala, ventromedial prefrontal cortex, and anterior insula. The Stage 1 manuscript was evaluated over three rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA). URL to the preregistered Stage 1 protocol: https://osf.io/btkwq Level of bias control achieved: Level 4. At least some of the data/evidence that will be used to answer the research question already exists AND is accessible in principle to the authors (e.g. residing in a public database or with a colleague), BUT the authors certify that they have not yet accessed any part of that data/evidence. List of eligible PCI RR-friendly journals:
References 1. Jost, J. T., & Hunyady, O. (2005). Antecedents and consequences of system-justifying ideologies. Current Directions in Psychological Science, 14, 260-265. https://doi.org/10.1111%2Fj.0963-7214.2005.00377.x 2. Balagtas, P. M., Tolomeo, S., Ragunath, B., Rigo, P., Bornstein, M. H. & Esposito, G. (2022). Neuroanatomical Correlates of System-justifying Ideologies: A Pre-registered Voxel-based Morphometry Study on Right-Wing Authoritarianism and Social Dominance Orientation in principle acceptance of version 4 by Peer Community in Registered Reports. https://osf.io/btkwq | Neuroanatomical Correlates of System-justifying Ideologies: A Pre-registered Voxel-based Morphometry Study on Right-Wing Authoritarianism and Social Dominance Orientation | Jan Paolo M. Balagtas, Serenella Tolomeo, Bindiya L. Ragunath, Paolo Rigo, Marc H. Bornstein & Gianluca Esposito | <p style="text-align: justify;">System-justifying ideologies are a cluster of ideals that perpetuate a hierarchical social system despite being fraught with inequalities. Right Wing Authoritarianism (RWA) and Social Dominance Orientation (SDO) are... | Social sciences | Chris Chambers | 2021-08-19 09:48:02 | |||
Neuroanatomical Correlates of System-justifying Ideologies: A Pre-registered Voxel-based Morphometry Study on Right-Wing Authoritarianism and Social Dominance OrientationNo definitive evidence for neuroanatomical correlates of system-justifying ideologiesRecommended by Chris Chambers based on reviews by Bonni Crawford and 1 anonymous reviewer
According to the tenets of system justification theory, system-justifying ideologies are beliefs held by individuals to defend and justify the status quo, even when doing do perpetuates social inequalities (Jost and Hunyady, 2005). Two such well-studied ideologies to emerge from political science and social psychology are social dominance orientation (SDO) – the belief that some social groups are superior to others – and right wing authoritarianism (RWA) – the belief that people should follow conventional traditions and authorities, avoiding rebellious ideas. Although considered to be stable traits that may have a heritable basis, there has been little investigation of the neural correlates of SDO and RWA, and it remains unknown whether they are associated with common or distinct brain systems.
In the current study, Balagtas et al. report a novel investigation of the neuroanatomical correlates of both SDO and RWA in a Chinese Singaporean sample using voxel-based morphometry. Based on previous research, the authors chose to focus especially on relationships between SDO, RWA and the volume of the amygdala, ventromedial prefrontal cortex, and anterior insula.
As predicted, the results showed a reliable positive correlation between measures of RWA and SDO; however, none of the neuroanatomical hypotheses were fully supported. Preregistered whole brain analyses revealed no significant regions associated with either RWA or SDO, while ROI analyses identified overlapping (including the amygdala and ventromedial prefrontal cortex) and non-overlapping regions (including left anterior insula) associated with RWA and SDO. Exploratory robustness checks suggested that the authors' spherical ROI localisation method may have identified clusters that were not within the amygdala or left anterior insula, prompting the need for future replication in a larger sample using more precise, atlas-based analyses.
The Stage 2 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/btkwq
Level of bias control achieved: Level 4. At least some of the data/evidence that was used to answer the research question already existed AND was accessible in principle to the authors (e.g. residing in a public database or with a colleague) BUT the authors certified that they had not yet accessed any part of that data/evidence prior to IPA.
List of eligible PCI RR-friendly journals:
References
1. Jost, J. T., & Hunyady, O. (2005). Antecedents and consequences of system-justifying ideologies. Current Directions in Psychological Science, 14, 260-265. https://doi.org/10.1111%2Fj.0963-7214.2005.00377.x
2. Balagtas, P. M., Tolomeo, S., Ragunath, B., Rigo, P., Bornstein, M. H. & Esposito, G. (2023). Neuroanatomical Correlates of System-justifying Ideologies: A Pre-registered Voxel-based Morphometry Study on Right-Wing Authoritarianism and Social Dominance Orientation. Stage 2 Registered Report, acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/nrqtz
| Neuroanatomical Correlates of System-justifying Ideologies: A Pre-registered Voxel-based Morphometry Study on Right-Wing Authoritarianism and Social Dominance Orientation | Jan Paolo M. Balagtas, Serenella Tolomeo, Bindiya L. Ragunath, Paola Rigo, Marc H. Bornstein & Gianluca Esposito | <p>System-justifying ideologies are a cluster of ideals that perpetuate a hierarchical social system despite being fraught with inequalities. Right Wing Authoritarianism (RWA) and Social Dominance Orientation (SDO) are two ideologies that have rec... | Social sciences | Chris Chambers | 2022-07-27 17:53:26 | |||
15 Jan 2024
STAGE 1
Neurophysiological correlates of plasticity induced by paired associative stimulation (PAS) targeting the motor cortex: a TMS-EEG registered reportCan TMS-evoked potentials act as biomarkers of long-term potentiation or long-term depression induced by paired associative stimulation?Recommended by Grace Edwards based on reviews by Domenica Veniero, Lindsay Oberman and 1 anonymous reviewer
What are the neurophysiological correlates of paired associative stimulation (PAS) in inducing plastic changes in human motor cortex (M1)? Here, Arrigoni and colleagues (2024) will apply transcranial magnetic stimulation (TMS) to left M1 paired with electrical stimulation of the right median nerve at an ISI of 25 ms or 10 ms to induce long-term potentiation (LTP) or long-term depression (LTD), respectively. Arrigoni and colleagues (2024) will determine if these stimulation pairings effect cortical excitability using motor-evoked potentials (MEPs) and TMS-evoked potentials (TEPs). Specifically, they hypothesize PASLTP will increase the peak-to-peak amplitude of MEPs, whereas PASLTD will decrease the amplitude, replicating previous work. They will then extend these previous findings by examining TEPs. The authors anticipate modulation of the P30 and P60, which are TEPs thought to reflect local cortical excitability. They plan to account for the MEP reafference which may also mediate the P60 amplitude by stimulating at sub- and supra- motor threshold. Further, they hypothesize an increase of the N100, a marker of inhibitory processing mediated by GABA, by PASLTD. Finally, the authors will also examine the impact of cortical excitability over time to determine the duration of the PAS effects.
This detailed examination of TEPs following PAS stimulation will determine which TEPs could be used as biomarkers with the induction of LTP and LTD through stimulation. The authors have built in an MEP replication for the PAS stimulation, supporting previous literature and acting as a positive control.
The Stage 1 manuscript was evaluated by three expert reviewers across two rounds. Following in-depth review and responses from the authors, the recommender determined that Stage 1 criteria was met and awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/detjc (under temporary private embargo)
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References 1. Arrigoni, E., Bolognini, N., Pisoni, A. & Guidali, G. (2024). Neurophysiological correlates of plasticity induced by paired associative stimulation (PAS) targeting the motor cortex: a TMS-EEG registered report. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/detjc | Neurophysiological correlates of plasticity induced by paired associative stimulation (PAS) targeting the motor cortex: a TMS-EEG registered report | Eleonora Arrigoni, Nadia Bolognini, Alberto Pisoni, Giacomo Guidali | <p>Paired associative stimulation (PAS) can induce long-term potentiation (LTP) and long-term depression (LTD) in the human motor system by applying transcranial magnetic stimulation (TMS) pulses on the primary motor cortex (M1) paired with electr... | Life Sciences | Grace Edwards | 2023-07-22 10:25:21 |
