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Latest recommendations

IdTitle * Authors * Abstract * PictureThematic fields * RecommenderReviewersSubmission date
19 Jan 2024
STAGE 1

A systematic review of social connection inventories

Improving the measurement of social connection

Recommended by ORCID_LOGO based on reviews by Jacek Buczny, Richard James and Alexander Wilson
This is an ambitious systematic review that uses a combination of quantitative and qualitative methods to make the measurement of the construct of social connection more rigorous. Social connection is a heterogeneous construct that includes aspects of structure, function and quality. Here, Paris et al. (2024) will use predefined methods to create a database of social connection measures, and will assess heterogeneity of items using human coders and ChatGPT. This database will form the basis of a second systematic review which will look at evidence for validity and measurement properties. This study will also look at the population groups and country of origin for which different measures were designed, making it possible to see how far culturally specific issues affect the content of measures in this domain.
 
The questions asked by this study are exploratory and descriptive and so the importance of pre-registration is in achieving clear criteria for how each question is addressed, rather than evidential criteria for hypothesis-testing.
 
The authors responded comprehensively to three reviewer reports. This study will provide a wealth of useful information for those studying social connection, and should serve to make the literature in this field more psychometrically robust and less fragmented.
 
URL to the preregistered Stage 1 protocol: https://osf.io/796uv
 
Level of bias control achieved: Level 3. At least some data/evidence that will be used to the answer the research question has been previously accessed by the authors (e.g. downloaded or otherwise received), but the authors certify that they have not yet observed ANY part of the data/evidence. 
 
List of eligible PCI RR-friendly journals:
 
 
References
 

1. Paris, B., Brickau, D., Stoianova, T., Luhmann, M., Mikton, C., Holt-Lunstad, J., Maes, A., & IJzerman, H. (2024). A systematic review of social connection inventories. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/796uv

A systematic review of social connection inventoriesBastien Paris, Debora Brickau, Tetiana Stoianova, Maike Luhmann, Christopher Mikton, Julianne Holt-Lunstad, Marlies Maes, Hans IJzerman<p>Social connection is vital to health and longevity. To date, a plethora of instruments exists to measure social connection, assessing a variety of aspects of social connection like loneliness, social isolation, or social support. For comparabil...Social sciencesDorothy Bishop Jacek Buczny, Alexander Wilson, Richard James2023-07-09 21:33:01 View
28 Jan 2025
STAGE 2
(Go to stage 1)

Unveiling the Positivity Bias on Social Media: A Registered Experimental Study On Facebook, Instagram, And X

Social media positivity bias, or just positivity bias?

Recommended by ORCID_LOGO based on reviews by Marcel Martončik, Julius Klingelhoefer and 1 anonymous reviewer
Both research and public debates around social media use tend to involve a premise of positivity bias, which refers to presenting one’s life in an overly positive light by various different means. This premise contributes to multiple potentially important follow-up hypotheses, such as the fear of missing out and low self-image effects, due to repeated consumption of positive social media content (e.g., Bayer et al. 2020, for a review). The positivity bias of social media use, itself, has received limited research attention. 
 
In the present study, Masciantonio and colleagues (2025) tested positivity bias in the context of three social media platforms: Facebook, Instagram, and X. The experiment involved recruiting participants (n=312) into platform-specific user groups and crafting posts to be shared with friends as well as respective social media audiences. For social media positivity bias to differ from everyday positivity bias, posts in the former should introduce more positive valence in comparison to offline sharing—and if the platforms differ in their encouragement of positivity bias, they should introduce significant between-platform differences in valence.
 
Based on how the participants reported events, the study found no significant differences between everyday and social media positivity bias, but messages posted on Twitter/X had a more negative valence than posts in other social media platforms. The results would be consistent with the implication that people's positive actions in social media simply follow the natural human tendency to present oneself positively to others—a hypothesis that should be investigated in follow-up work. More research attention should also be given to specific design features, which may contribute to platform-specific differences in user habits, as suggested by the distinct valence rate found in relation to Twitter/X.
 
The Stage 2 manuscript was evaluated by three experts (areas: experimental methods, social media, statistics) via in-depth peer review across two rounds, with one reviewer returning to validate analysis code and methdological accuracy on a final round. Based on the authors’ careful responses and revisions, the revised manuscript was judged to meet the Stage 2 criteria and was awarded a positive recommendation. 
 
URL to the preregistered Stage 1 protocol: https://osf.io/9z6hm
 
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA.  
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Bayer, J. B., Triệu, P., & Ellison, N. B. (2020). Social media elements, ecologies, and effects. Annual review of psychology, 71, 471-497. https:// doi.org/10.1146/annurev-psych-010419-050944
 
2. Masciantonio, A., Heiser, N., & Cherbonnier, A. (2025). Unveiling the Positivity Bias on Social Media: A Registered Experimental Study On Facebook, Instagram, And X [Stage 2]. Acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/s93yu 
Unveiling the Positivity Bias on Social Media: A Registered Experimental Study On Facebook, Instagram, And XAlexandra Masciantonio, Neele Heiser, Anthony Cherbonnier<p>Social media has transformed how people engage with the world around them. The positivity bias on social media, in particular, warrants in-depth investigation. This is particularly true as previous research has concentrated on one specific plat...Social sciencesVeli-Matti Karhulahti Marcel Martončik2024-09-23 11:20:07 View
31 May 2024
STAGE 1

Unveiling the Positivity Bias on Social Media: A Registered Experimental Study On Facebook, Instagram, And X

Social media positivity bias

Recommended by ORCID_LOGO based on reviews by Linda Kaye, Marcel Martončik, Julius Klingelhoefer and 1 anonymous reviewer
Both research and public debates around social media use tend to involve a premise of positivity bias, which refers to presenting one’s life in an overly positive light by various different means. This premise contributes to multiple potentially important follow-up hypotheses, such as the fear of missing out and low self-image effects, due to repeated consumption of positive social media content (e.g., Bayer et al. 2020, for a review). The positivity bias of social media use, itself, has received limited research attention, however. 
 
In the present study, Masciantonio and colleagues (2024) will test positivity bias in the context of three social media platforms: Facebook, Instagram, and X. The experiment involves recruiting participants into platform-specific user groups and crafting posts to be shared with friends as well as respective social media audiences. If positivity bias manifests in this context, the social media posts should introduce more positive valence in comparison to offline sharing—and if the platforms differ in their encouragement of positivity bias, they should introduce significant between-platform differences in valence.
 
The Stage 1 plan was reviewed by four independent experts representing relevant areas of methodological and topic expertise. Three reviewers proceeded throughout three rounds of review, after which the study was considered having met all Stage 1 criteria and the recommender granted in-principle acceptance. 
 
URL to the preregistered Stage 1 protocol: https://osf.io/9z6hm
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.  
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Bayer, J. B., Triệu, P., & Ellison, N. B. (2020). Social media elements, ecologies, and effects. Annual review of psychology, 71, 471-497. https:// doi.org/10.1146/annurev-psych-010419-050944
 
2. Masciantonio, A., Heiser, N., & Cherbonnier, A. (2024). Unveiling the Positivity Bias on Social Media: A Registered Experimental Study On Facebook, Instagram, And X. In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/9z6hm
Unveiling the Positivity Bias on Social Media: A Registered Experimental Study On Facebook, Instagram, And XA. Masciantonio, N. Heiser, A. Cherbonnier<p>Social media has transformed how people engage with the world around them. The positivity bias on social media, in particular, warrants in-depth investigation. This is particularly true as previous research has concentrated on one specific plat...Social sciencesVeli-Matti Karhulahti2024-01-15 10:33:52 View
03 Mar 2025
STAGE 1

Shape of SNARC: How task-dependent are Spatial-Numerical Associations? A highly powered online experiment

Shedding light on task influence in the SNARC effect

Recommended by ORCID_LOGO based on reviews by Michele Vicovaro, Christian Seegelke, Peter Wühr and 1 anonymous reviewer
The Spatial-Numerical Association of Response Codes (SNARC) effect (Dehaene et al., 1993) is a key phenomenon in numerical cognition. It describes the tendency for individuals to respond faster to smaller numbers with a left-side key and to larger numbers with a right-side key, suggesting a mental mapping of numerical magnitudes onto space. While this effect has been widely replicated, its precise nature remains debated, particularly regarding its task dependency.
 
In this Stage 1 Registered Report, Roth et al. (2025) present a highly powered study that systematically investigates whether the SNARC effect differs in two widely used numerical cognition tasks: magnitude classification (MC) and parity judgment (PJ). In the MC task, participants determine whether a presented number is smaller or larger than a reference value (typically 5). This task explicitly requires magnitude processing, making numerical magnitude directly relevant to the response. In contrast, the PJ task requires participants to judge whether a number is odd or even, a decision that does not explicitly involve numerical magnitude.
 
The authors address a fundamental theoretical question in numerical cognition: while the SNARC effect in PJ is often considered continuous, does it follow a categorical pattern in MC? To investigate this, the study directly compares continuous and categorical representations of the SNARC effect across these two tasks, using Bayesian statistical approaches to determine the best-fitting model. By systematically analysing the SNARC effect in these widely used paradigms, this work aims to refine our understanding of how numerical magnitudes are mapped onto space and whether this mapping depends on task demands. The findings of this study will provide crucial insights into the cognitive mechanisms underlying numerical-spatial associations, highlighting the extent to which task structure shapes the emergence of the SNARC effect.
 
Three expert reviewers provided valuable feedback across multiple rounds of review. Based on ​detailed responses to the reviewers’ and recommender’s comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.​​​
 
URL to the preregistered Stage 1 protocol: https://osf.io/968ad
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Dehaene, S., Bossini, S., & Giraux, P. (1993). The mental representation of parity and number magnitude. Journal of Experimental Psychology: General, 122(3), 371–396. https://doi.org/10.1037/0096-3445.122.3.371
 
2. Roth, L., Cipora, K., Overlander, A. T., Nuerk, H.-C., & Reips, U.-D. (2025). Shape of SNARC: How task-dependent are Spatial-Numerical Associations? A highly powered online experiment. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/968ad
Shape of SNARC: How task-dependent are Spatial-Numerical Associations? A highly powered online experimentLilly Roth, Krzysztof Cipora, Annika T. Overlander, Hans-Christoph Nuerk, Ulf-Dietrich Reips<p>Spatial-Numerical Associations (SNAs) are fundamental to numerical cognition. They are essential for number representation and mathematics learning. However, SNAs are highly dependent on the experimental situation and task. Understanding this d...Life SciencesMario Dalmaso Peter Wühr2024-05-27 13:14:25 View
25 Oct 2023
STAGE 1

Does pupillometry provide a valid measure of spatial attentional bias (pseudoneglect)?

Assessing visuospatial biases (pseudoneglect) using pupillometry: A replication and extension of Strauch et al. (2022)

Recommended by ORCID_LOGO based on reviews by Christoph Strauch and Bianca Hatin
‘Pseudoneglect’ is a small, lateralised bias of visuospatial attention towards the left side of space, and is typically observed in healthy adults. Recently, Strauch et al. (2022) reported that bright stimuli presented in the left visual field induced a greater constriction of the pupil (the pupillary light reflex) compared to the same bright stimuli presented in the right visual field. Further, the pupillary restriction bias was positively correlated with a behavioural measure of pseudoneglect (the greyscales task). This is potentially an important development for attention research, because the passive nature of the task, in addition to the ability to track the time course of the bias measures, could provide a new, and highly sensitive, method of studying spatial attention.
 
In this report, Burns and McIntosh (2023) aim to replicate and extend the study of Strauch et al. (2022). The extension centres around investigating whether the pupillary biases are influenced by recording pupillary responses from the right or left eye. In their pilot replication data, Burns & McIntosh identified a larger constriction in response to stimuli on the right side when recording from the right eye. They hypothesise that pupillary biases may be stronger to stimuli presented in the ipsilateral, rather than contralateral, side of space.
 
The Stage 1 manuscript was reviewed over 2 rounds by 2 reviewers, including the authors of the study being replicated. Based on detailed responses to the reviewers’ comments and edits to the Stage 1 report, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.
 
URL to the preregistered Stage 1 protocol: https://osf.io/ua9jn

Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI-RR-friendly journals:
 
References
 
1. Strauch, C., Romein, C., Naber, M., Van der Stigchel, S. & Ten Brink, A. F. (2022). The orienting response drives pseudoneglect—Evidence from an objective pupillometric method. Cortex, 151, 259-271.
 
2. Burns, N. E. & McIntosh, R. D. (2023). Does pupillometry provide a valid measure of spatial attentional bias (pseudoneglect)? In principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/ua9jn
Does pupillometry provide a valid measure of spatial attentional bias (pseudoneglect)?Nicola E. Burns, and Robert D. McIntosh<p>Strauch et al. (2022) introduced a novel approach to assess biases of visual attention, by measuring pupillary constriction in response to split-field stimuli, in which a bright patch is presented to one visual field and a dark patch to the oth...Social sciencesGemma Learmonth Christoph Strauch2023-07-12 18:27:28 View
23 Jan 2025
STAGE 1

Mapping methodological variation in experience sampling research from design to data analysis: A systematic review

Methodological Variation in the Experience Sampling Methods: Can We Do ESM Better?

Recommended by ORCID_LOGO based on reviews by Priya Silverstein and 1 anonymous reviewer
The replication crisis/credibility revolution has driven a vast number of changes to our research environment (Korbmacher et al., 2023) including a much needed spotlight on issues surrounding measurement (Flake & Fried, 2020). As general understanding and awareness has increased surrounding the 'garden of forking paths' or 'researcher degrees of freedom' (Simmons et al., 2011), and the various decisions made during the scientific process that could impact the conclusions drawn by the process, so too should our interest in meta-research that tells us more about the methodological processes we follow, and how discretionary decisions may influence the design, analysis and reporting of a project.
 
Peeters et al. (2025) have proposed a systematic literature review of this nature, mapping the methodological variation in experience sampling methods (ESM) from the design stage all the way to dissemination. It starts this journey by mapping how ESM studies vary e.g., in design, considering a variety of factors like sample size, number of measurements, and sampling scheme. It also evaluates reporting quality, rationales provided, and captures the extent of open science practices adopted. Covering many parts of the research process that get assumed, unreported or otherwise unjustified, the proposed work looks set to springboard an important body of work that can tell us more effectively how to design, implement and report ESM studies.
 
The Stage 1 submission was reviewed over one round of in-depth review with two reviewers. Based on detailed responses to reviewers’ feedback, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.
 
URL to the preregistered Stage 1 protocol: https://osf.io/ztvn3
 
Level of bias control achieved: Level 1. At least some of the data/evidence that will be used to the answer the research question has been accessed and observed by the authors, including key variables, but the authors certify that they have not yet performed any of their preregistered analyses, and in addition they have taken stringent steps to reduce the risk of bias.
 
List of eligible PCI-RR-friendly journals:
 
References
 
1. Flake, J. K., & Fried, E. I. (2020). Measurement schmeasurement: Questionable measurement practices and how to avoid them. Advances in Methods and Practices in Psychological Science, 3, 456-465. https://doi.org/10.1177/2515245920952393
 
2. Korbmacher, M., Azevedo, F., Pennington, C. R., Hartmann, H., Pownall, M., Schmidt, K., ... & Evans, T. (2023). The replication crisis has led to positive structural, procedural, and community changes. Communications Psychology, 1, 3. https://doi.org/10.1038/s44271-023-00003-2
 
3. Peeters, L., Van Den Noortgate, W., Blanchard, M. A., Eisele, G., Kirtley, O., Artner, R., & Lafit, G. (2025). Mapping Methodological Variation in ESM Research from Design to Data Analysis: A Systematic Review. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/ztvn3
 
4. Simmons, J. P., Nelson, L. D., & Simonsohn, U. (2011). False-positive psychology: Undisclosed flexibility in data collection and analysis allows presenting anything as significant. Psychological Science, 22, 1359-1366. https://doi.org/10.1177/0956797611417632
Mapping methodological variation in experience sampling research from design to data analysis: A systematic reviewLisa Peeters, Wim Van Den Noortgate, M. Annelise Blanchard, Gudrun Eisele, Olivia Kirtley, Richard Artner, Ginette Lafit<p><strong>Aim</strong>. The Experience Sampling Method (ESM) has become a widespread tool to study time-varying constructs across many subfields of psychological and psychiatric research. This large variety in subfields of research and constructs...Social sciencesThomas Evans2024-09-04 10:39:37 View
14 Apr 2023
STAGE 1

Can playing Dungeons and Dragons be good for you? A registered exploratory pilot program using offline Tabletop Role-Playing Games (TTRPGs) to mitigate social anxiety and reduce problematic involvement in multiplayer online videogames

Expanding the Intervention Potential of Tabletop Role-Playing Games

Recommended by ORCID_LOGO based on reviews by Charlotte Pennington, Matúš Adamkovič and Matti Vuorre
The human capacity and need for play has been recognized as a central psychotherapeutic component for a long time (e.g. Winnicott 1971). More recently, experts have started developing specialized digital gameplay to be used as therapeutic tools and even utilizing existing videogames for similar purposes (see Ceranoglu 2010). On the other hand, the concerns about some players becoming overinvolved in videogames also led the World Health Organization to include “gaming disorder” in the 11th edition of the International Classification of Diseases, which echoes the nuance required to address human-technology relationships in general.  
 
In the present registered report, Billieux et al. (2023) make use of analog structured role-play in a new intervention aiming to mitigate social anxiety and problematic gaming patterns in online gamers. The authors carry out an exploratory pilot to test a 10-week protocol over three modules inspired by the well-known Dungeons & Dragons franchise. Through multiple single-case design, the authors explore the feasibility of the intervention and its effectiveness on social skills, self-esteem, loneliness, assertiveness, and gaming disorder symptoms.
 
The Stage 1 manuscript was evaluated over two rounds by three experts with experimental specializations in psychopathology and gaming. Based on the comprehensive responses to the reviewers' feedback, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/h7qat

Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals
 
 
References
 
1. Billieux  J., Bloch J., Rochat L., Fournier L., Georgieva I., Eben C., Andersen M. M., King D. L., Simon O., Khazaal Y. & Lieberoth A. (2023). Can playing Dungeons and Dragons be good for you? A registered exploratory pilot program using offline Tabletop Role-Playing Games (TTRPGs) to mitigate social anxiety and reduce problematic involvement in multiplayer online videogames. In principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/h7qat
 
2. Ceranoglu, T. (2010). Video Games in Psychotherapy. Review of General Psychology, 14 (2). https://doi.org/10.1037/a0019439
 
3. Winnicott, D. (1971/2009). Playing and Reality. Routledge.
Can playing Dungeons and Dragons be good for you? A registered exploratory pilot program using offline Tabletop Role-Playing Games (TTRPGs) to mitigate social anxiety and reduce problematic involvement in multiplayer online videogamesJoël Billieux, Jonathan Bloch, Lucien Rochat, Loïs Fournier, Iliyana Georgieva, Charlotte Eben, Marc Malmdorf Andersen, Daniel Luke King, Olivier Simon, Yasser Khazaal, Andreas Lieberoth<p><strong>Background</strong>. Gamers with poor self-concept, high social anxiety, and high loneliness are more at risk of problematic involvement in videogames and particularly in massively multiplayer online role-playing games (MMORPGs) than ot...Social sciencesVeli-Matti Karhulahti Matti Vuorre, Charlotte Pennington, Matúš Adamkovič2023-02-06 11:09:55 View
21 Jan 2025
STAGE 2
(Go to stage 1)

Can playing Dungeons and Dragons be good for you? A registered exploratory pilot program using offline Tabletop Role-Playing Games (TTRPGs) to mitigate social anxiety and reduce problematic involvement in multiplayer online video games

Expanding the Intervention Potential of Tabletop Role-Playing Games

Recommended by ORCID_LOGO based on reviews by Charlotte Pennington, Matúš Adamkovič and Matti Vuorre
The human capacity and need for play has been recognized as a central psychotherapeutic component for a long time (e.g. Winnicott 1971). More recently, experts have started developing specialized digital gameplay to be used as therapeutic tools and even utilizing existing videogames for similar purposes (see Ceranoglu 2010). On the other hand, the concerns about some players becoming overinvolved in videogames also led the World Health Organization to include “gaming disorder” in the 11th edition of the International Classification of Diseases, which echoes the nuance required to address human-technology relationships in general.  
 
In the present registered report, Billieux et al. (2024) make use of analog structured role-play in a new intervention aiming to mitigate social anxiety and problematic gaming patterns in online gamers. The authors carried out an exploratory pilot to test a 10-week protocol over three modules inspired by the well-known Dungeons & Dragons franchise. Through a multiple single-case design with a 3-month follow-up, the authors carried out the pilot with 20 participants (two dropped out), which enabled collecting valuable early data about the feasibility and potential of the intervention. 
 
Weekly psychometric assessments indicated that the intervention may support participants and it should continue to be studied in order to comprehensively evaluate its effectiveness. Feedback obtained from participants and other parts of the pilot project enabled identifying elements (e.g., difficulty adjustments), which can be given attention usefully in intervention development. Without question, the study by Billieux et al. (2024) is to be commended for highly transparent documentation of the project, which allows future researchers and intervention developers to learn from the pilot beyond initial results. Among other relevant materials, the supplements provide a detailed case study and item-level psychometric reporting, which can help the development of technical solutions and new hypotheses.
 
Taken together, the study by Billieux et al. (2024) paves the way for open science invention piloting in the field. The Stage 2 manuscript was evaluated by three experts (areas: experimental methods, psychopathology, gaming) via in-depth peer review across two rounds. Based on the authors’ careful responses and revisions, the revised manuscript was judged to meet the Stage 2 criteria and was awarded a positive recommendation. 
 
URL to the preregistered Stage 1 protocol: https://osf.io/h7qat

Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA.
 
List of eligible PCI RR-friendly journals
 
 
References
 
1. Billieux, J., Fournier, L., Rochat, L., Georgieva, I., Eben, C., Malmdorf Andersen, M., King, D., Simon, O., Khazaal, Y., Lieberoth, A. & Blocha., J. (2024) Can playing Dungeons and Dragons be good for you? A registered exploratory pilot program using offline Tabletop Role-Playing Games (TTRPGs) to mitigate social anxiety and reduce problematic involvement in multiplayer online videogames [Stage 2 RR]. Acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/z32d5
 
2. Ceranoglu, T. (2010). Video Games in Psychotherapy. Review of General Psychology, 14 (2). https://doi.org/10.1037/a0019439
 
3. Winnicott, D. (1971/2009). Playing and Reality. Routledge.
Can playing Dungeons and Dragons be good for you? A registered exploratory pilot program using offline Tabletop Role-Playing Games (TTRPGs) to mitigate social anxiety and reduce problematic involvement in multiplayer online video gamesJoël Billieux, Loïs Fournier, Lucien Rochat, Iliyana Georgieva, Charlotte Eben, Marc Malmdorf Andersen, Daniel L. King, Olivier Simon, Yasser Khazaal, Andreas Lieberoth, Jonathan Bloch<p><strong>Background</strong>. Gamers with poor self-concept, high social anxiety, and high loneliness are more at risk of problematic involvement in video games, particularly in massively multiplayer online role-playing games (MMORPGs). There is...Social sciencesVeli-Matti Karhulahti Matúš Adamkovič, Matti Vuorre, Charlotte Pennington2024-08-30 11:29:55 View
26 Nov 2024
STAGE 1

The Importance of Long- and Short-Acting Pharmacological Treatment Options for Time Use and Quality of Life in Individuals with Opioid Use Disorder: An Observational, Cross-Sectional, Survey-Based Study

Examining distinct patterns of time-use and their associations with quality of life in individuals receiving treatment for opioid use disorder

Recommended by based on reviews by Chris Chambers, Cathy Montgomery and 1 anonymous reviewer
Drug use is a time-consuming endeavour, particularly for opioids, whereby substantial time is required to seek out, prepare and consume drugs. This prioritization of drug use reduces the time that is available for substance-free alternatives that contribute positively to quality of life, such as socialization, education, employment, physical activity and self-care (Acuff et al., 2019). Given the time commitments, daily supervised treatment of opioid use disorder has poor adherence (Strang et al., 2020). As such, there is an interest in long-acting injectable medications, which can overcome these adherence issues (Saunders et al 2020). However, little is known about how patients on long-acting medications for opioid use disorder adapt to the increased free-time they have, and where this has downstream impacts on their well-being, quality of life and experience of stigma.
 
In the current study, Trøstheim and colleagues plan to conduct an observational investigation of >500 individuals from Norway with opioid use disorder who were receiving pharmacological treatment. Their primary hypothesis is that individuals with opioid use disorder will exhibit distinct time use profiles, which will be examined using latent profile analysis to identify time use patterns based on 17 measured time use variables e.g. ‘How many days in the past week have you done paid work, voluntary work, or community service’. Secondary analyses will test the associations between medication type, time use (based on the latent profile analysis), well-being, stigma and life-satisfaction. Findings from this study will provide a greater understanding of how long-acting medications for opioid use disorder impact free-time and quality of life.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review by two reviewers and the recommender. Following a response and revision, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/vbpjg
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI-RR-friendly journals:
 
 
References
 
1. Acuff, S. F., Dennhardt, A. A., Correia, C. J., & Murphy, J. G. (2019). Measurement of substance-free reinforcement in addiction: A systematic review. Clinical Psychology Review, 70, 79-90. https://doi.org/10.1016/j.cpr.2019.04.003
 
2. Saunders, E. C., Moore, S. K., Walsh, O., Metcalf, S. A., Budney, A. J., Scherer, E., & Marsch, L. A. (2020). Perceptions and preferences for long-acting injectable and implantable medications in comparison to short-acting medications for opioid use disorders. Journal of Substance Abuse Treatment, 111, 54-66. https://doi.org/10.1016/j.jsat.2020.01.009
 
3. Strang, J., Volkow, N. D., Degenhardt, L., Hickman, M., Johnson, K., Koob, G. F., ... & Walsh, S. L. (2020). Opioid use disorder. Nature Reviews Disease Primers, 6, 3. https://doi.org/10.1038/s41572-019-0137-5
 
4. Trøstheim, M., Leknes, S., Solli, K. K., Carlyle, M., Ernst, G., & Eikemo, M. (2024). The Importance of Long- and Short-Acting Pharmacological Treatment Options for Time Use and Quality of Life in Individuals with Opioid Use Disorder: An Observational, Cross-Sectional, Survey-Based Study. In principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/vbpjg
The Importance of Long- and Short-Acting Pharmacological Treatment Options for Time Use and Quality of Life in Individuals with Opioid Use Disorder: An Observational, Cross-Sectional, Survey-Based StudyMartin Trøstheim, Siri Leknes, Kristin K. Solli, Molly Carlyle, Gernot Ernst, Marie Eikemo<p><strong>Background. </strong>Pharmacological treatment for opioid use disorder with new, long-acting medications (e.g., injectable and implantable buprenorphine) frees up a considerable amount of patients’ time otherwise spent seeking illicit o...Medical Sciences, Social sciencesAndrew Jones Chris Chambers, Cathy Montgomery2024-06-28 11:11:22 View
11 Apr 2023
STAGE 2
(Go to stage 1)

Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery

Is childhood adversity associated with a heightened response to opioids?

Recommended by ORCID_LOGO based on reviews by Zoltan Dienes, Yuki Yamada and 1 anonymous reviewer
A convergence of evidence suggests that early life adversity may cause dysfunction in opioid-sensitive reward systems. Childhood adversity is associated with opioid use, potentially by altering reward and motivation networks, and experimental models in animals have found that early life adversity increases and consolidates opioid seeking behaviours. Further, in a recent controlled experiment, Carlyle et al. (2021) found that opioid administration produced stronger positive responses, and weaker negative responses, in adults with a history of childhood abuse and neglect.
 
In the current study, Carlyle et al. (2023) tested the generalisability of these previous findings in a pre-operative clinical setting. Using partially observed data from an existing cohort study (N=155), the authors asked whether patients with greater experience of childhood trauma in turn exhibit a larger mood boost and express greater subjective pleasure following opioid administration.
 
In contrast to previous findings, the results did not support the hypotheses that more experiences of childhood adversity would heighten ratings of drug liking and feeling good following opioid administration. Regression analyses instead revealed a statistically significant negative association between childhood adversity and post-opioid liking and no significant relationship with feeling good. The authors suggest that the discrepancy between the current and previous results may be due to stress related to the pre-surgical setting, the brief duration of drug exposure, and the relatively limited levels of high childhood adversity in the study sample. Nevertheless, these findings cast some doubt on the theory that adversity elevates risk of opioid addiction by altering sensitivity to subjectively pleasurable effects.
 
Following one round of in-depth review, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
 
URL to the preregistered Stage 1 protocol: https://osf.io/7ymts
 
Level of bias control achieved: Level 2. At least some data/evidence that was used to answer the research question had been accessed and partially observed by the authors prior to IPA, but the authors certify that they had not yet observed the key variables within the data that were used to answer the research question AND they took additional steps to maximise bias control and rigour. 
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Carlyle M., Broomby R., Simpson G., Hannon R., Fawaz L., Mollaahmetoglu O.M., Drain, J., Mostazir, M., & Morgan C. (2021). A randomised, double‐blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine. Addiction Biology, 26(6):e13047. https://doi.org/10.1111/adb.13047
 
2. Carlyle, M., Kvande, M., Meier, I. M., Trøstheim, M., Buen, K., Jensen, E. N., Ernst, G. & Leknes, S. & Eikemo, M. (2023). Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery, acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/9kt3a?view_only=4238d2ee3d654c4f908a94efea82a027
Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgeryMolly Carlyle1*, Malin Kvande*, Isabell M. Meier, Martin Trøstheim, Kaja Buen, Eira Nordeng Jensen, Gernot Ernst, Siri Leknes, Marie Eikemo (*denotes equal contribution)<p><strong>Introduction</strong>: Opioid analgesic treatment during surgery entails risk of persistent use. Experiences of childhood adversity have been shown to increase opioid reward in preclinical models, a finding recently extended to healthy ...Medical Sciences, Social sciencesChris Chambers2023-02-02 08:29:18 View