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Latest recommendations
| Id | Title * | Authors * | Abstract * | Picture | Thematic fields * | Recommender▲ | Reviewers | Submission date | |
|---|---|---|---|---|---|---|---|---|---|
The effect of covert visual attention on pupil size during perceptual fadingDoes pupil size track high-level attention?Recommended by D. Samuel Schwarzkopf based on reviews by Sander Nieuwenhuis and Martin Rolfs
Higher-level cognitive processes like attention, memory, or mental imagery can produce pupil responses, without any actual difference in luminance of the visual stimulus. Interestingly, the inverse scenario remained untested to date: when a physical luminance difference is perceptually eliminated from awareness, does pupil size still track attention to the stimulus? In this Registered Report, Vilotijević and Mathôt (2024) sought to test this experimentally using a perceptual fading phenomenon where two Gaussian patches with different luminances fade from consciousness and are thus perceived as mid-level uniform grey (or at least the subjective difference is much reduced). This fading manipulation, as well as a control condition without perceptual fading, were presented in separate blocks. Participants were instructed to covertly attend one of the patches.
The authors hypothesised that if pupil size reflects attentional selection, these pupil responses in the fading condition should be eliminated or at least reduced, and this should evolve with time as the stimuli are perceptually fading. Their results show that pupil responses during covert attention are indeed reduced during perceptual fading - but they are not eliminated. Interestingly, this reduction did not depend on time or self-reports of the strength of perceptual fading. The findings therefore suggest that pupil dilation tracks subjective brightness differences. One inherent issue with experiments like these is that the experimental and control conditions necessarily involve a physical difference in the stimulus. Here, the fading condition had the same spatial configuration of light and dark stimuli throughout a block while in the control (non-fading) condition the light and dark stimuli alternated sides between trials. It is therefore impossible to completely rule out that the physical difference affects the results. However, the only alternative to this would be an experimental design in which the stimuli never change, but only the subjective perceptual state varies. Such a design is completely at the mercy of the participant's subjective state and therefore loses experimental control and statistical sensitivity. The present results confirmed the authors' prediction that there are indeed differences in overall pupil responses during the fading and control conditions, irrespective of covert attention.
Critically, the fact that the attention effect did not vary with time or subjective self-reports of the illusion supports the authors' interpretation that this reflects higher-level cognition: the mere act of attending to the dark side - even if the actual appearance has faded - could cause a sustained pupil dilation. This would be consistent with the type of pupil effects for memory and mental imagery that motivated the present study. However, a simpler alternative is that the experience of perceptual fading was incomplete (as possibly suggested by Figures 2D and 2F) but that self-reports fail to capture this subjective experience accurately. Perhaps a future study could compare the magnitude of the attentional pupil effects when the initial stimulus is completely removed. If similar differences in pupil response persist this would suggest that the present results are due to high-level modulation or the residual low-level luminance difference.
The Stage 2 manuscript was evaluated by two reviewers and the recommender over two rounds of review. One reviewer again advised additional robustness checks to rule out eye movement confounds, an issue they had already raised during Stage 1 review. The researchers provide clear evidence that this is unlikely to have confounded their findings. This has been added to the supplementary data repository. Following this review and revision, the recommender judged that the Stage 2 criteria were met and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/bmtp6
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA. List of eligible PCI RR-friendly journals:
References
1. Vilotijević, A. & Mathôt, S. (2024). The effect of covert visual attention on pupil size during perceptual fading [Stage 2]. Acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/ku8qc?view_only=f331df53b50f431386fabba9e386b387
| The effect of covert visual attention on pupil size during perceptual fading | Ana Vilotijević, Sebastiaan Mathôt | <p>Pupil size is modulated by various cognitive factors such as attention, working memory, mental imagery, and subjective perception. Previous studies examining cognitive effects on pupil size mainly focused on inducing or enhancing a subjective e... | Social sciences | D. Samuel Schwarzkopf | 2024-08-17 12:58:58 | |||
04 Feb 2025
STAGE 1
Evaluating Loneliness Measurements across the European UnionMeasuring loneliness in the European UnionRecommended by Elizabeth Renner and Robert McIntosh based on reviews by Thuy-vy Nguyen, Joe Bathelt, Drew Altschul and Mary Louise Pomeroy
Loneliness is increasingly a focus of governments and health systems due to its potential adverse effects. Various ways to measure it have been developed but the psychometric properties of common instruments have not yet been evaluated across all countries in the European Union (EU).
In this study, Paris et al. (2025) will examine three measures of loneliness across 27 EU member countries. An online survey (n = 25,646) incorporated three instruments which were translated into national languages: the De Jong Gierveld Loneliness Scale (6 items), the three-item UCLA Loneliness Scale (3 items), and a single-item measure (“How much of the time, during the past 4 weeks, have you been feeling lonely”). The factor structure, internal consistency, and measurement invariance for the 6- and 3-item measures will be assessed, as well as the construct validity of all three measures using nomological networks. The authors have adopted an n-fold procedure to analyse the data, with a first exploratory fold using half of the data to establish hypotheses for each question and a second confirmatory fold using the remainder of the data to test the hypotheses. The results of the study will provide important information about the psychometric properties of commonly used loneliness instruments, and can indicate which measures are appropriate for loneliness monitoring across the EU.
The study plan was refined across four rounds of in-depth review with input from four reviewers, Thuy-vy Nguyen, Joe Bathelt, Mary Louise Pomeroy, and Drew Altschul, and the recommenders, after which it was judged to meet the Stage 1 criteria and received in-principle acceptance.
URL to the preregistered Stage 1 protocol: https://osf.io/2s38v Level of bias control achieved: Level 3. At least some data/evidence that will be used to the answer the research question has been previously accessed by the authors (e.g. downloaded or otherwise received), but the authors certify that they have not yet observed ANY part of the data/evidence List of eligible PCI RR-friendly journals:
References
Paris, B., Ropovik, I., Silan, M., d'Hombres, B., Casabianca, E., & IJzerman, H. (2025). Evaluating Loneliness Measurements across the European Union. In principle acceptance of Version 4 by Peer Community in Reigstered Reports. https://osf.io/2s38v
| Evaluating Loneliness Measurements across the European Union | Bastien Paris, Ivan Ropovik, Miguel Silan, Béatrice d'Hombres, Elizabeth Casabianca, Hans IJzerman | <p>Loneliness has been associated with several detrimental effects for individuals and societies, making it a priority for monitoring across the European Union. While many loneliness measures currently exist, notable gaps exist regarding knowledge... | Social sciences | Elizabeth Renner | 2023-11-17 14:30:30 | |||
25 Mar 2024
STAGE 1
The role of positive and negative emotions on multiple components of episodic memory (“what”, “when”, “in which context”) in older compared to younger adults: a pre-registered studyThe role of emotion and age on different facets of episodic memory (“what”, “when”, “in which context”)Recommended by Elizabeth Wonnacott based on reviews by Mara Mather and 1 anonymous reviewer
How does emotion influence item memory (what?) temporal memory (when?) and associative memory (in which context?), and does this differ for younger and older adults? Previous research has found inconsistent results, possibly due to small sample sizes. In this study, Laulan and Rimmele (2024) and will build on the paradigm in Palombo et al. (2021) in which participants see images embedded in videos and are asked to remember the images (what?), their temporal position within the videos (where?), and the association between the images and the videos (in which context?). Image valence (positive vs negative vs neutral) and participant age-group (18-30 vs 60-80 yr olds) are manipulated. Pre-registered analyses will first look at the two age groups separately to test for an effect of valence for each of the memory components, and second test for modulating effects of age-group. To be cost-effective, a sequential analysis approach with statistical analyses conducted at three time points and a maximum sample size of 150 younger and 150 older adults is planned.
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/z4e8j
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References 1. Laulan, P. & Rimmele, U. (2024). The role of positive and negative emotions on multiple components of episodic memory (“what”, “when”, “in which context”) in older compared to young adults: a pre-registered study. In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/z4e8j
2. Palombo, D. J., Te, A. A., Checknita, K. J. & Madan, C. R. (2021). Exploring the Facets of Emotional Episodic Memory: Remembering “What,” “When,” and “Which”. Psychological Science, 32, 1104–1114. https://doi.org/10.1177/0956797621991548
| The role of positive and negative emotions on multiple components of episodic memory (“what”, “when”, “in which context”) in older compared to younger adults: a pre-registered study | Pierrick Laulan, Ulrike Rimmele | <p>Emotion and age modulate episodic memory. In both young and older adults, emotion has a beneficial effect on item memory, with an advantage for positive vs. negative stimuli in older adults. In young adults, emotion has also been shown to enhan... | Social sciences | Elizabeth Wonnacott | 2023-04-12 16:58:21 | |||
07 Dec 2023
STAGE 1
Investigating individual differences in linguistic statistical learning and their relation to rhythmic and cognitive abilities: A speech segmentation experiment with online neural trackingIndividual differences in linguistic statistical learning and the relationship to rhythm perceptionRecommended by Elizabeth Wonnacott based on reviews by 2 anonymous reviewers
Previous research has demonstrated that experimental participants – both adults and infants – can track syllable co-occurrences in an artificial speech stream. This statistical learning (SL) is thought to support word segmentation and to be a core component of language acquisition. There is also some evidence that SL, as measured through artificial language tasks, is related to individual differences in language learning. What is not well understood is the underpinnings of individual differences in SL. In the current study, van der Wulp et al. (2023) will investigate the relationship between auditory SL and musical – specifically rhythmic – abilities. This work takes advantage of recent methodological innovations which allow online assessment of SL via electroencephalography (EEG) measures of neural entrainment. Up to N=105 participants will be recruited (using a well specified optional stopping procedure) and will be exposed to an artificial language using this EEG method to measure their response to the language through the exposure phase. In addition, post-tests will assess participants’ learning of the artificial language using behavioural tasks, as well as their abilities in a battery of tasks measuring rhythmic, musical, and cognitive abilities, and their vocabulary size. Core analyses will investigate whether the neural signature of statistical learning is found at a group level (i.e. replicating previous work) and whether at the individual level this is related to rhythm perception. Bayes factors will be used to assess the extent of evidence for these hypothesized relationships over the null. Exploratory analyses will explore other relationships, including with working memory and vocabulary size.
The topic of individual differences in language learning and is important, but work in this area is often underpowered, and the correlational nature of the research makes it vulnerable to HARKing. In this context, the current RR looks set to make an important contribution. The Stage 1 manuscript was evaluated over two rounds of in-depth review by the recommender and two expert reviewers, and one additional round of review by the recommender, before issuing in-principle acceptance.
URL to the preregistered Stage 1 protocol: https://osf.io/2y6sx
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals: References
1. van der Wulp, I. M., Struiksma, M. E., Batterink, L. J., & Wijnen, F. N. K. (2023). Investigating individual differences in linguistic statistical learning and their relation to rhythmic and cognitive abilities: A speech segmentation experiment with online neural tracking. In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/2y6sx | Investigating individual differences in linguistic statistical learning and their relation to rhythmic and cognitive abilities: A speech segmentation experiment with online neural tracking | Iris van der Wulp, Marijn Struiksma, Laura Batterink, Frank Wijnen | <p><strong>Objective:</strong> Statistical Learning (SL) is an essential mechanism for speech segmentation. Importantly, individual differences in SL ability are associated with language acquisition. For instance, better SL correlated with a large... | Humanities, Social sciences | Elizabeth Wonnacott | 2023-05-03 10:53:51 | |||
01 Jul 2024
STAGE 1
The Influence of Bilingualism on Statistical Word Learning: A Registered ReportComparing statistical word learning in bilinguals and monolingualsRecommended by Elizabeth Wonnacott based on reviews by 2 anonymous reviewers
Many studies have investigated the extent to which word learning is underpinned by statistical learning, i.e. tracking probabilistic relationships between forms and referents. Previous literature has investigated whether these processes differ in bilingual learners – who have to track two such sets of mappings in their linguistic environment. However, the evidence is mixed: some say bilinguals have a learning advantage and some find no evidence of differences.
The current study by Simonetti et al. (2024) aims to further explore this in an experiment using the cross-situational word learning paradigm. In this paradigm participants hear words and view arrays of object across a series of trials. Taking each trial in isolation the word is ambiguous, but there are consistent co-occurrences of words with referents across the trials. Two groups of participants will be compared: monolingual English speaker and English-German bilinguals. Using this paradigm, the study can track learning over time as well as looking at individual trial by trial analyses. The researchers predict specifically that bilingual learners will have a specific advantage in learning 1:2 mappings, where one-word maps to two objects. The study will use Bayes Factors as the method of inference when analysing the data, allowing them to differentiate evidence for "no difference" from ambiguous evidence from which no conclusion can be drawn.
The Stage 1 manuscript was evaluated over four rounds of review. Based on detailed responses to the reviewers' and recommender's comments, the recommender judged that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/8n5gh
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals: References Simonetti, M. E., Lorenz, M. G., Koch, I., & Roembke, T. C. (2024). The Influence of Bilingualism on Statistical Word Learning: A Registered Report. In principle acceptance of Version 5 by Peer Community in Registered Reports. https://osf.io/8n5gh
| The Influence of Bilingualism on Statistical Word Learning: A Registered Report | Simonetti, M. E., Lorenz, M. G., Koch, I., & Roembke, T. | <p>While statistical word learning has been the focus of many studies on monolinguals, it has<br>received little attention in bilinguals. The results of existing studies on statistical word learning<br>in bilinguals are inconsistent, with some res... | Social sciences | Elizabeth Wonnacott | 2023-06-28 15:37:58 | |||
22 Jul 2024
STAGE 1
Replication of “Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions”Replicating, Revising and Reforming: Unpicking the Apparent Nanoparticle Endosomal Escape ParadoxRecommended by Emily Linnane and Yuki Yamada based on reviews by Cecilia Menard-Moyon and Zeljka Krpetic
Context
Over the past decade there has been an exponential increase in the number of research papers utlising nanoparticles for biological applications such as intracellular sensing [1, 2], theranostics [3-5] and more recently drug delivery and precision medicine [6, 7]. Despite the success stories, there is a disconnect regarding current dogma on issues such as nanoparticle uptake and trafficking, nanoparticle delivery via the enhanced permeability and retention (EPR) effect, and endosomal escape. Critical re-evaluation of these concepts both conceptually and experimentally is needed for continued advancement in the field.
For this preregistration, Said et al. (2024) focus on nanoparticle intracellular trafficking, specifically endosomal escape [8]. The current consensus in the literature is that nanoparticles enter cells via endocytosis [9, 10] but reportedly just 1-2% of nanoparticles/ nanoparticle probes escape endosomes and enter the cytoplasm [11-13]. There is therefore an apparent paradox over how sensing nanoparticles can detect their intended targets in the cytoplasm if they are trapped within the cell endosomes. To address this fundamental issue of nanoparticle endosomal escape, Lévy and coworkers are carrying out replication studies to thoroughly and transparently replicate the most influential papers in the field of nanoparticle sensing. The aim of these replication studies is twofold: to establish a robust methodology to study endosomal escape of nanoparticles, and to encourage discussions, transparency and a step-change in the field.
Replication of “Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions”
For this replication study, the authors classified papers on the topic of nanoparticle sensing and subsequently ranked them by number of citations. Based on this evaluation they selected a paper by Zhu and colleagues [14] entitled “Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions” for their seminal replication study. To determine the reproducibility of the results from Zhu et al., the authors aim to establish the proportion of endosomal escape of the nanoparticles, and to examine the data in a biological context relevant to the application of the probe.
Beyond Replication
The authors plan to replicate the exact conditions reported in the materials and methods section of the selected paper such as nanoparticle probe synthesis of CdSe@C-TPEA nanoparticles, assessment of particle size, stability and reactivity and effect on cells (TEM, pH experiments, fluorescent responsivity to metal ions and cell viability). In addition, Said et al., plan to include further experimental characterisation to complement the existing study by Zhu and colleagues. They will incorporate additional controls and methodology to determine the intracellular location of nanoparticle probes in cells including: quantifying excess fluorescence in the culture medium, live cell imaging analysis, immunofluorescence with endosomal and lysosomal markers, and electron microscopy of cell sections. The authors will also include supplementary viability studies to assess the impact of the nanoparticles on HeLa cells as well as an additional biologically relevant cell line (for use in conjunction with the HeLa cells as per the original paper).
The Stage 1 manuscript underwent two rounds of thorough in-depth review. After considering the detailed responses to the reviewers' comments, the recommenders determined that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).
The authors have thoughtfully considered their experimental approach to the replication study, whilst acknowledging any potential limitations. Given that conducting such a replication study is novel in the field of Nanotechnology and there is currently no ‘gold standard’ approach in doing so, the authors have showed thoughtful regard of statistical analysis and unbiased methodology where possible.
Based on current information, this study is the first use of preregistration via Peer Community in Registered Reports and the first formalised replication study in Nanotechnology for Biosciences. The outcomes of this of this study will be significant both scientifically and in the wider context in discussion of the scientific method.
URL to the preregistered Stage 1 protocol: https://osf.io/qbxpf
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly Journals:
References
1. Howes, P. D., Chandrawati, R., & Stevens, M. M. (2014). Colloidal nanoparticles as advanced biological sensors. Science, 346(6205), 1247390. https://doi.org/10.1126/science.1247390
2. Liu, C. G., Han, Y. H., Kankala, R. K., Wang, S. B., & Chen, A. Z. (2020). Subcellular performance of nanoparticles in cancer therapy. International Journal of Nanomedicine, 675-704. https://doi.org/10.2147/IJN.S226186
3. Tang, W., Fan, W., Lau, J., Deng, L., Shen, Z., & Chen, X. (2019). Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics. Chemical Society Reviews, 48(11), 2967-3014. https://doi.org/10.1039/C8CS00805A
4. Yoon, Y. I., Pang, X., Jung, S., Zhang, G., Kong, M., Liu, G., & Chen, X. (2018). Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics. Journal of Materials Chemistry B, 6(20), 3235-3239. https://doi.org/10.1039%2FC8TB00368H
5. Lin, H., Chen, Y., & Shi, J. (2018). Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy. Chemical Society Reviews, 47(6), 1938-1958. https://doi.org/10.1039/C7CS00471K
6. Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021). Lipid nanoparticles for mRNA delivery. Nature Reviews Materials, 6(12), 1078-1094. https://doi.org/10.1038/s41578-021-00358-0
7. Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021). Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery, 20(2), 101-124. https://doi.org/10.1038/s41573-020-0090-8
8. Said, M., Gharib, M., Zrig, S., & Lévy, R. (2024). Replication of “Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions”. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/qbxpf
9. Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., ... & Mahmoudi, M. (2017). Cellular uptake of nanoparticles: Journey inside the cell. Chemical Society Reviews, 46(14), 4218-4244. https://doi.org/10.1039/C6CS00636A
10. de Almeida, M. S., Susnik, E., Drasler, B., Taladriz-Blanco, P., Petri-Fink, A., & Rothen-Rutishauser, B. (2021). Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine. Chemical society reviews, 50(9), 5397-5434. https://doi.org/10.1039/D0CS01127D
11. Smith, S. A., Selby, L. I., Johnston, A. P., & Such, G. K. (2018). The endosomal escape of nanoparticles: toward more efficient cellular delivery. Bioconjugate Chemistry, 30(2), 263-272. http://dx.doi.org/10.1021/acs.bioconjchem.8b00732
12. Cupic, K. I., Rennick, J. J., Johnston, A. P., & Such, G. K. (2019). Controlling endosomal escape using nanoparticle composition: current progress and future perspectives. Nanomedicine, 14(2), 215-223. https://doi.org/10.2217/nnm-2018-0326
13. Wang, Y., & Huang, L. (2013). A window onto siRNA delivery. Nature Biotechnology, 31(7), 611-612. https://doi.org/10.1038/nbt.2634
14. Zhu, A., Qu, Q., Shao, X., Kong, B., & Tian, Y. (2012). Carbon-dot-based dual-emission nanohybrid produces a ratiometric fluorescent sensor for in vivo imaging of cellular copper ions. Angewandte Chemie (International ed. in English), 51(29), 7185-7189. https://doi.org/10.1002/anie.201109089
| Replication of “Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions” | Maha Said, Mustafa Gharib, Samia Zrig, Raphaël Lévy | <p>In hundreds of articles published over the past two decades, nanoparticles have been described as probes for sensing and imaging of a variety of intracellular cytosolic targets. However, nanoparticles generally enter cells by endocytosis with o... | | Life Sciences, Medical Sciences, Physical Sciences | Emily Linnane | 2023-11-29 19:14:03 | ||
14 Aug 2023
STAGE 1
Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception?Understanding oscillatory correlates of pain expectationRecommended by Gemma Learmonth based on reviews by Zoltan Dienes, Chris Chambers and Markus Ploner
Recent studies using an EEG frequency tagging approach have reported modulations of alpha, beta and theta bands at the stimulation frequency during nociceptive/painful thermal stimulation compared to non-nociceptive/non-painful vibrotactile stimulation. Prior expectations of the intensity of upcoming painful stimuli are known to strongly modulate the subjective experience of those stimuli. Thus, modulating the expectation of pain should result in a change in the modulation of oscillations if these factors are indeed linked.
In this study, Leu, Glineur and Liberati will modulate expectations of pain (low or high intensity) prior to delivering thermal cutaneous stimulation (low, medium or high intensity). They will record how intense participants expect the pain to be, and how intense they felt it to be, as well as record EEG to assess oscillatory differences across the expectation and intensity conditions.
The Stage 1 manuscript was reviewed over 5 rounds by 3 reviewers. Based on detailed responses to the reviewers’ comments and edits to the Stage 1 report, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.
URL to the preregistered Stage 1 protocol: https://osf.io/y6fb8
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals: References
1. Leu, C., Glineur, E. & Liberati, G. (2023). Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception? In principle acceptance of Version 5 by Peer Community in Registered Reports. https://osf.io/y6fb8 | Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception? | Chiara Leu, Esther Glineur, Giulia Liberati | <p>A promising stream of investigations is targeting ongoing neural oscillations and whether their modulation could be relevant for the perception of pain. Specifically, sustained periodic thermonociceptive stimuli have been shown to modulate ongo... | Medical Sciences | Gemma Learmonth | Zoltan Dienes | 2023-03-15 14:41:03 | ||
25 Oct 2023
STAGE 1
Does pupillometry provide a valid measure of spatial attentional bias (pseudoneglect)?Assessing visuospatial biases (pseudoneglect) using pupillometry: A replication and extension of Strauch et al. (2022)Recommended by Gemma Learmonth based on reviews by Christoph Strauch and Bianca Hatin
‘Pseudoneglect’ is a small, lateralised bias of visuospatial attention towards the left side of space, and is typically observed in healthy adults. Recently, Strauch et al. (2022) reported that bright stimuli presented in the left visual field induced a greater constriction of the pupil (the pupillary light reflex) compared to the same bright stimuli presented in the right visual field. Further, the pupillary restriction bias was positively correlated with a behavioural measure of pseudoneglect (the greyscales task). This is potentially an important development for attention research, because the passive nature of the task, in addition to the ability to track the time course of the bias measures, could provide a new, and highly sensitive, method of studying spatial attention.
In this report, Burns and McIntosh (2023) aim to replicate and extend the study of Strauch et al. (2022). The extension centres around investigating whether the pupillary biases are influenced by recording pupillary responses from the right or left eye. In their pilot replication data, Burns & McIntosh identified a larger constriction in response to stimuli on the right side when recording from the right eye. They hypothesise that pupillary biases may be stronger to stimuli presented in the ipsilateral, rather than contralateral, side of space.
The Stage 1 manuscript was reviewed over 2 rounds by 2 reviewers, including the authors of the study being replicated. Based on detailed responses to the reviewers’ comments and edits to the Stage 1 report, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.
URL to the preregistered Stage 1 protocol: https://osf.io/ua9jn
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI-RR-friendly journals:
References
1. Strauch, C., Romein, C., Naber, M., Van der Stigchel, S. & Ten Brink, A. F. (2022). The orienting response drives pseudoneglect—Evidence from an objective pupillometric method. Cortex, 151, 259-271.
2. Burns, N. E. & McIntosh, R. D. (2023). Does pupillometry provide a valid measure of spatial attentional bias (pseudoneglect)? In principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/ua9jn | Does pupillometry provide a valid measure of spatial attentional bias (pseudoneglect)? | Nicola E. Burns, and Robert D. McIntosh | <p>Strauch et al. (2022) introduced a novel approach to assess biases of visual attention, by measuring pupillary constriction in response to split-field stimuli, in which a bright patch is presented to one visual field and a dark patch to the oth... | Social sciences | Gemma Learmonth | Christoph Strauch | 2023-07-12 18:27:28 | ||
Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception? A Registered ReportUnderstanding oscillatory correlates of pain expectationRecommended by Gemma Learmonth based on reviews by Zoltan Dienes, Chris Chambers and Markus Ploner
Recent studies using an EEG frequency tagging approach have reported modulations of alpha, beta and theta bands at the stimulation frequency during nociceptive/painful thermal stimulation compared to non-nociceptive/non-painful vibrotactile stimulation. Prior expectations of the intensity of upcoming painful stimuli are known to strongly modulate the subjective experience of those stimuli. Thus, modulating the expectation of pain should result in a change in the modulation of oscillations if these factors are indeed linked.
In this study, Leu, Glineur and Liberati modulated expectations of pain (low or high intensity) in 40 participants prior to delivering thermal cutaneous stimulation (low, medium or high intensity). They recorded how intense participants expected the pain to be, and how intense they felt it to be, as well as EEG to assess oscillatory differences across the expectation and intensity conditions.
The results confirmed that there was a strong effect of expectation on the perceived stimulus intensity. However, contrary to the hypotheses, this was not reflected in the cortical oscillations. Overall this indicates a possible dissociation between perceived pain and modulation of ongoing oscillations in the theta, alpha and beta bands.
The Stage 2 manuscript was evaluated over one round of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/y6fb8
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA. List of eligible PCI RR-friendly journals: References
1. Leu, C., Glineur, E. & Liberati, G. (2023). Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception? [Stage 2] Acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/awrge | Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception? A Registered Report | Chiara Leu, Esther Glineur, Giulia Liberati | <p style="text-align: justify;">A promising stream of investigations is targeting ongoing neural oscillations and whether their modulation could be related to the perception of pain. Using an electroencephalography (EEG) frequency tagging approach... | Life Sciences, Medical Sciences | Gemma Learmonth | 2024-01-23 19:35:39 | |||
22 Jul 2024
STAGE 1
From Thought to Senses: Assessing the Presence of a Relationship Between the Generation Effect and Multisensory FacilitationExploring multi-sensory benefits in the generation effect of memoryRecommended by Gidon Frischkorn based on reviews by Vanessa Loaiza, Sharon Bertsch and Vanessa Loaiza
This study by Ritchie and Wilbiks (2024) investigates whether the generation effect, a memory advantage for self-generated verbal information, is enhanced under multisensory conditions. It is designed to explore a gap in the literature regarding the interplay between the generation effect and multisensory facilitation, with potential applications in educational settings.
Exploring multisensory aspects of the generation effect, the study has the potential to provide new insights into cognitive processing and memory enhancement. It is well rooted in established theories of the generation effect and multisensory facilitation, deducing a reasonable hypothesis that multisensory processing amplifies the generation effect. By implementing a 2 (Task Type: generate vs. read) x 3 (Sensory Modality: auditory, visual, multisensory) factorial design, it ensures a comprehensive evaluation of multisensory benefits in the generation effect. The findings could inform multisensory learning strategies in educational contexts, enhancing teaching methods and learning outcomes. Based on these considerations and two rounds of in-depth review, the recommender awarded in-principle acceptance of the study proposal. Its strong theoretical foundation and well-conceived methodology make it a valuable contribution to the fields of cognitive and educational psychology. URL to the preregistered Stage 1 protocol: https://osf.io/3u7eh
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
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References
Ritchie, M. & Wilbiks, J. (2024). From Thought to Senses: Assessing the Relationship Between the Generation Effect and Multisensory Facilitation. In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/3u7eh
| From Thought to Senses: Assessing the Presence of a Relationship Between the Generation Effect and Multisensory Facilitation | Michaela Ritchie, Jonathan Wilbiks | <p>The proposed study will investigate the relationship between the generation effect, a memory advantage for self-generated verbal information, and the multisensory facilitation effect, a phenomenon wherein congruent sensory inputs enhance cognit... | Social sciences | Gidon Frischkorn | 2024-02-01 18:34:15 |
