Thank you for your revised submission. I have now received comments on your Stage 2 manuscript from the one reviewer (Bonni Crawford) with major concerns, particularly regarding the ROI analyses. As you will see, most issues are now resolved, but there are some remaining clarifications required concerning the details and reporting of the new analyses. These issues appear to be readily addressable. I will evaluate your next (and hopefully final) revision/response at desk, and provided you are able to comprehensively address these points, I anticipate being able to award a final Stage 2 recommendation without further in-depth review.

I now have two evaluations of your Stage 2 manuscript, kindly provided by the two reviewers who assessed the proposal at Stage 1. As you will see, one of the reviewers is broadly satisfied, asking for minor changes (including some key adjustments to the language). However, the other reviewer (Bonni Crawford) notes a potential error, or at least imprecision, in the ROI localisation method that we need to attend to carefully before proceeding with full acceptance. At Stage 2, is unusual for additional analyses to be required, but in this case I think that the reviewer's suggestion for an additional exploratory analysis is well made, and indeed likely to be essential to ensure that Stage 2 Criterion 2E is met (that the conclusions are based on the evidence). Note that the original analysis should be maintained, and this additional analysis added as transparently post hoc. I look forward to your revision and response, which I will return to the reviewer for further consideration. Note also that changes to the Introduction section should be minimal.