Associations between anxiety-related traits and fear acquisition and extinction - an item-based content and meta-analysisuse asterix (*) to get italics

Maria Bruntsch, Samuel E Cooper, Rany Abend, Marian Boor, Anastasia Chalkia, Mana Ehlers, Artur Czeszumski, Dave Johnson, Maren Klingelhöfer-Jens, Jayne Morriss, Erik Mueller, Ondrej Zika, Tina Lonsdorf Please use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

2024

<p>Background: Deficits in learning and updating of fear and safety associations have been reported in patients suffering from anxiety- and stress-related disorders. Also in healthy individuals, anxiety-related traits have been linked to altered fear conditioning and extinction performances in the literature. Yet, different studies focus on different experimental phases, specific outcome measures and specific questionnaires to assess anxiety-related traits. What is missing at this point is an integrative approach on how anxiety-related traits are associated with fear conditioning and extinction performance, limiting effective translation of experimental insight on these etiology- and treatment-relevant processes to the clinic.&nbsp;</p> <p>Methods: To address this gap we will conduct a systematic literature search and meta-analysis following PRISMA guidelines. We will use a series of nested random effects models to investigate the associations between anxiety-related traits and frequently used outcome measures of fear conditioning and extinction (e.g. psychophysiological and self-reports). Different questionnaires used in these studies to assess anxiety-related traits will be further used as moderators to inform us on whether the association between fear conditioning and extinction performance might be contingent on the specific questionnaire used.<br>Furthermore, we will conduct an item-based content analysis of the questionnaires used in the identified studies to assess anxiety-related traits. The Jaccard similarity coefficient will be used to evaluate the content overlap between pairs of questionnaires. This analysis will help to evaluate the similarities (or dissimilarities) between anxiety-related traits as assessed through different questionnaires and to further inform the interpretation of the meta-analytical results.</p>

Fear learning, threat learning, aversive learning, fear conditioning, acquisition, extinction, individual differences, anxiety-related traits, meta-analysis

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Life Sciences

Yoann Stussi suggested: Dr. M. Alexandra Kredlow (xandra.kredlow@tufts.edu) , Yoann Stussi suggested: Dr. Gaëtan Mertens (G.Mertens@tilburguniversity.edu) , Yoann Stussi suggested: Juliana Sporrer (juliana.sporrer.18@ucl.ac.uk) , Yoann Stussi suggested: Dr. Matthias J. Wieser (wieser@essb.eur.nl) , Gaëtan Mertens suggested: Dear Sara, , Gaëtan Mertens suggested: This looks like very interesting work, however in this specific period I am quite swamped with educational tasks and I am unfortunately not able to submit a full review within 5 days in this period. , Gaëtan Mertens suggested: As alternative reviewers, I can recommend reaching out to Alex Wong (h.k.wong@essb.eur.nl), Yannick Boddez (Yannick.Boddez@UGent.be), Rachel Sjouwerman (), and/or Bart Endhoven (b.endhoven@uu.nl). , Gaëtan Mertens suggested: Kind regards, , Gaëtan Mertens suggested: Gaetan

e.g. John Doe john@doe.com

No need for them to be recommenders of PCI Registered Reports. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct

2024-03-15 14:48:20

Sara Garofalo

Anonymous, Marco Badioli, Yoann Stussi, Luigi Degni