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IdTitle * Authors * Abstract * PictureThematic fields * RecommenderReviewersSubmission date
24 Apr 2024
STAGE 1

Synaesthesia as a Model for Assessing Individual Differences in Visual Perception and Memory Performance

What can synaesthesia tell us about links between perception and memory?

Recommended by ORCID_LOGO based on reviews by Janina Neufeld, David Brang and Tessa van Leeuwen
What is the relationship between perception and memory? Although these topics are typically investigated separately, there is evidence that these cognitive processes may be related: for example, individuals with synaesthesia may experience both enhancements in visual acuity and visual memory; and individuals with amnesia may also show deficits in visual perceptual processing. However, comprehensive evidence for the relationship between perception and different forms of memory (both short-term and long-term) is currently lacking.
 
In this Stage 1 manuscript, Whelan et al. (2024) seek to elucidate this relationship by investigating individual differences in perception and memory in a general population sample (i.e., in synaesthetes, non-synaesthetic relatives, and controls). There are two accounts that may explain enhanced perception and memory in synaesthesia: a ‘dual-coding’ account, which suggests that the extra perceptual information often experienced in synaesthesia (e.g., seeing colors for different letters of the alphabet) may contribute to encoding richer information in sensory memory; and an ‘enhanced processing’ account, which posits that enhanced perception and memory in synaesthesia may be due to genetic or environmental factors not directly related to synaesthetic experiences. In the former case, synaesthetes should perform more similarly to each other than to their non-synaesthetic relatives; in the latter case, non-synaesthetic relatives of synaesthetes should show similar perceptual and memory benefits. The current study should therefore find evidence in favor of one of these accounts over the other. In addition to this, the authors will generate multidimensional cognitive profiles of synaesthetes and their relatives, compared to non-synaethetes, including perception, memory, mental imagery and cognitive styles. 
 
The Stage 1 submission was evaluated by the recommender and two expert reviewers. Following revisions, the recommender judged that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/6h8dx (under temporary private embargo)
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Whelan, E., Sachdeva, C., Ovalle-Fresa, R., Rothen R., & Ward, J. (2024). Synaesthesia as a Model for Assessing Individual Differences in Visual Perception and Memory Performance. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/6h8dx
Synaesthesia as a Model for Assessing Individual Differences in Visual Perception and Memory PerformanceEmily Whelan, Chhavi Sachdeva, Rebecca Ovalle-Fresa, Nicolas Rothen and Jamie Ward<p>In this study, the cognitive profile of synaesthesia (a perceptual condition in which primary experiences, such as perceiving digits or words, elicit extra secondary sensations) is used as a model system to assess visual perceptual abilities an...Social sciencesReshanne Reeder2023-11-07 13:02:39 View
28 Sep 2023
STAGE 1

Investigating the barriers and enablers to data sharing behaviours: A qualitative Registered Report

Capability, Opportunity, and Motivation in Data Sharing Behaviour

Recommended by ORCID_LOGO based on reviews by Moin Syed, Peter Branney and Libby Bishop
In the past two decades, most academic fields have witnessed an open science revolution that has led to significant increases in open access publishing, reproducibility efforts, and scientific transparency in general (e.g., Spellman et al. 2018). One of the key areas in this ongoing change is data sharing. Although some evidence already points at progress in data sharing practices, many new datasets remain unshared (see Tedersoo et al. 2021).
 
In the present registered report, Henderson et al. (2023) empirically explore the factors that either hinder or facilitate data sharing in the UK. By means of semi-structured interviews, the team will chart researchers’ experiences of sharing and non-sharing. Thematic template analysis will be applied to organise the data into a hierarchical map of capabilities, opportunities, and motivations in a theoretical domains framework (COM-B-TDF). The research plan itself meets the highest open science standards and reflects on the authors own positions, from which the current qualitative interview data sharing efforts will be made.
 
The Stage 1 manuscript was reviewed over three rounds by three experts with familiary of the UK cultural context and specializations in open science practices, qualitative research, and data infrastructures. Based on careful revisions and detailed responses to the reviewers’ comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.
 
URL to the preregistered Stage 1 protocol: https://osf.io/2gm5s (under temporary private embargo)
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.  
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Henderson, E., Marcu, A., Atkins, L. & Farran, E.K. (2023). Investigating the barriers and enablers to data sharing behaviours: A qualitative Registered Report. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/2gm5s
 
2. Spellman, B. A., Gilbert, E. A. & Corker, K. S. (2018). Open Science. Stevens' Handbook of Experimental Psychology and Cognitive Neuroscience, 5, 1-47. https://doi.org/10.1002/9781119170174.epcn519
 
3. Tedersoo, L., Küngas, R., Oras, E., Köster, K., Eenmaa, H., Leijen, Ä., ... & Sepp, T. (2021). Data sharing practices and data availability upon request differ across scientific disciplines. Scientific data, 8, 192. https://doi.org/10.1038/s41597-021-00981-0
Investigating the barriers and enablers to data sharing behaviours: A qualitative Registered ReportEmma L Henderson, Afrodita Marcu, Lou Atkins, Emily K Farran<p>Data sharing describes the process of making research data available for reuse. The availability of research data is the basis of transparent, effective research systems that democratise access to knowledge and advance discovery. Despite a broa...Social sciencesVeli-Matti Karhulahti2023-05-11 19:18:48 View
28 Feb 2024
STAGE 2
(Go to stage 1)

Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting quality

Evidence for mixed quality of systematic reviews in preclinical animal studies of neurodevelopmental conditions

Recommended by ORCID_LOGO based on reviews by Marietta Papadatou-Pastou
Single gene alterations have been estimated to account for nearly half of neurodevelopmental conditions (NDCs), providing a crucial opportunity for animal models to understand the underlying mechanisms, causes and potential treatments. The use of systematic reviews (SRs) can, in principle, provide a powerful means to synthesise this evidence-base; however, the reporting quality of previous SRs in preclinical animal research has been found lacking (Hunniford et al., 2021). In the current study, Wilson et al. (2023) will undertook a review of systematic reviews to assess the characteristics and reporting quality of SRs that, in turn, synthesise research in genetically-modified animals to model NDCs. In particular, the authors extracted key features of reviews (including, among others, the aim and primary research questions, relevant animal model, and number of studies in the SR), in addition to quality indicators such as risk of bias and completeness of reporting. In doing so, the authors aimed to enhance guidance on the conduct and reporting of systematic reviews in this area.
 
Of twelve publications that met the preregistered search criteria, the completeness and quality of reporting was variable. Among the better reported characteristics were search strategies (9 of 12 articles), reporting of funding sources (10 of 12 articles) and use of animal data (11 of 12 articles). In contrast, only two articles reported whether the study protocol was preregistered, only three articles reported methods for assessing risk of bias, and just one included methods to analyse publication bias. In addition, the authors identified 19 review registrations via PROSPERO, most of which remained unpublished after their anticipated end dates. Overall, the results highlight the importance of adherence to reporting guidelines for increasing the transparency and reproducibility of SRs in this field.
 
The Stage 2 manuscript was evaluated over one round of in-depth review. Based on detailed responses by the authors, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
 
URL to the preregistered Stage 1 protocol: https://osf.io/952qk
 
Level of bias control achieved: Level 4. At least some of the data/evidence that was used to answer the research question already existed prior to IPA and was accessible in principle to the authors, but the authors certify that they did not access any part of that data/evidence prior to IPA.
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Hunniford V. T., Montroy J., Fergusson D. A., Avey M. T., Wever K. E., McCann S. K., Foster M., Fox G., Lafreniere M., Ghaly M., Mannell S., Godwinska K., Gentles A., Selim S., MacNeil J., Sikora L., Sena E. S., Page M. J., Macleod M., Moher D., & Lalu M. M. (2021). Epidemiology and reporting characteristics of preclinical systematic reviews. PLOS Biology, 19:e3001177. https://doi.org/10.1371/journal.pbio.3001177
 
2. Wilson, E., Currie, G., Macleod, M., Kind, P. & Sena, E. S. (2023). Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting quality [Stage 2]. Acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/s5xd4
Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting qualityEmma Wilson, Gillian Currie, Malcolm Macleod, Peter Kind, and Emily S Sena<p><strong>Objective</strong><br>Using genetically-modified animals to model neurodevelopmental conditions (NDCs) helps better our understanding of biology underlying these conditions. Animal research has unique characteristics not shared with cli...Medical SciencesChris Chambers2023-11-22 10:26:44 View
23 Jan 2023
STAGE 1

Genetically-modified animals as models of neurodevelopmental conditions: an umbrella review

Evaluating the quality of systematic reviews in preclinical animal studies of neurodevelopmental conditions

Recommended by ORCID_LOGO based on reviews by Marietta Papadatou-Pastou and Richel Bilderbeek
Single gene alterations have been estimated to account for nearly half of neurodevelopmental conditions (NDCs), providing a crucial opportunity for animal models to understand the underlying mechanisms, causes and potential treatments. The use of systematic reviews (SRs) can, in principle, provide a powerful means to synthesise this evidence-base; however, the reporting quality of previous SRs in preclinical animal research has been found lacking (Hunniford et al., 2021). In the current study, Wilson et al. (2023) will undertake an umbrella review – a systematic review of systematic reviews – to assess the characteristics and reporting quality of SRs that, in turn, synthesise research in genetically-modified animals to model NDCs. In particular, the authors will extract key features of reviews (including, among others, the aim and primary research questions, relevant animal model, and number of studies in the SR), in addition to quality indicators such as risk of bias and completeness of reporting. In doing so, the authors aim to enhance guidance on the conduct and reporting of systematic reviews in this area.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/952qk
 
Level of bias control achieved: Level 4. At least some of the data/evidence that will be used to answer the research question already exists AND is accessible in principle to the authors BUT the authors certify that they have not yet accessed any part of that data/evidence.
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Hunniford V. T., Montroy J., Fergusson D. A., Avey M. T., Wever K. E., McCann S. K., Foster M., Fox G., Lafreniere M., Ghaly M., Mannell S., Godwinska K., Gentles A., Selim S., MacNeil J., Sikora L., Sena E. S., Page M. J., Macleod M., Moher D., & Lalu M. M. (2021). Epidemiology and reporting characteristics of preclinical systematic reviews. PLOS Biology, 19:e3001177. https://doi.org/10.1371/journal.pbio.3001177
 
2. Wilson, E., Currie, G., Macleod, M., Kind, P. & Sena, E. S. (2023). Genetically-modified animals as models of neurodevelopmental conditions: an umbrella review, in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/952qk
Genetically-modified animals as models of neurodevelopmental conditions: an umbrella reviewEmma Wilson; Gillian Currie; Malcolm Macleod; Peter Kind; Emily S Sena<p><strong>Objective</strong><br>Using genetically-modified animals to model neurodevelopmental conditions (NDCs) helps better our understanding of their underlying biology. In vivo research has unique characteristics not shared with clinical rese...Life SciencesChris Chambers2022-08-29 12:08:51 View
08 Sep 2023
STAGE 1

Evaluation of spatial learning and wayfinding in a complex maze using immersive virtual reality. A registered report

Evaluation of an immersive virtual reality wayfinding task

Recommended by ORCID_LOGO based on reviews by Conor Thornberry, Gavin Buckingham and 1 anonymous reviewer
The Virtual Maze Task (VMT) is a digital desktop 2D spatial learning task that has been used for research into the effect of sleep and dreaming on memory consolidation (e.g. Wamsley et al, 2010). One limitation of this task has been low rates of reported dream incorporation. Eudave and colleagues (2023) have created an immersive virtual reality (iVR) version of the VMT, which they believe might be more likely to be incorporated into dreams. As an initial step in validating this task for research, they propose a within-subjects study to compare three measures of spatial learning between the 2D desktop and iVR versions. Based on a review of relevant literature, the prediction is that performance will be similar between the two task versions. The planned sample size (n = 62) is sufficient for a .9 power test of equivalence within effect size bounds of d = -.47 to .47. Additional independent variables (gender, perspective-taking ability) and dependent measures (self-reported cybersickness and sense of presence) will be recorded for exploratory analyses.
 
The study plan was refined across four rounds of review, with input from two external reviewers and the recommender, after which it was judged to satisfy the Stage 1 criteria for in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/wba2v
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 
 
References
 
Eudave, L., Martínez, M., Valencia, M., & Roth D. (2023). Evaluation of spatial learning and wayfinding in a complex maze using immersive virtual reality. A registered report. In principle acceptance of Version 5 by Peer Community in Registered Reports.
 
Wamsley, E. J., Tucker, M., Payne, J. D., Benavides, J. A., & Stickgold, R. (2010). Dreaming of a learning task is associated with enhanced sleep-dependent memory consolidation. Current Biology, 20, 850–855. https://doi.org/10.1016/j.cub.2010.03.027
 
† There is one minor change that the authors should make to the Methods section, which is sufficiently small that it can be incorporated at Stage 2: "if both tests reject the null hypothesis (observed data is less/greater than the lower/upper equivalence bounds), conditions are considered statistically equivalent" >> suggest changing "less/greater" to "greater/lesser" for correct correspondence with "lower/upper".
Evaluation of spatial learning and wayfinding in a complex maze using immersive virtual reality. A registered reportEudave L., Martínez M., Valencia M., Roth D.<p style="text-align: justify;"><strong>Objectives</strong>: Mazes have traditionally been used as tools for evaluating spatial learning and navigational abilities in humans. They have been also utilized in sleep and dream research, as wayfinding ...Life SciencesRobert McIntosh2023-03-31 17:21:20 View
29 Jun 2022
STAGE 1
article picture

Go above and beyond: Does input variability affect children’s ability to learn spatial adpositions in a novel language?

Can discriminative learning theory explain productive generalisation in language?

Recommended by ORCID_LOGO based on reviews by Julien Mayor, Natalia Kartushina, Caroline Rowland and 1 anonymous reviewer
One of the major challenges in studies of language learning is understanding productive generalisation – the ability to use words and linguistic structures in novel settings that the learner has never encountered previously. According to discriminative learning theory, this skill arises from an iterative process of prediction and error-correction that gradually reduces uncertainty, allowing learners to discriminate linguistic outcomes and to identify informative, invariant cues for generalisation to novel cases. In the current study, Viviani et al (2022) use computational modelling to propose a central hypothesis stemming from this theory that children will learn the meaning and use of spatial adpositions (words such as “above” and “below” that describe relative positions) more effectively when there is more variability in the use of the nouns within the spatial sentences. They will also test a range of additional hypotheses, including that learning and generalisation to novel contexts will be enhanced when children learn from skewed distributions that are similar to those found in natural languages.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/37dxr
 
Level of bias control achieved: Level 6. Some of the data that will be used in the preregistered analyses was obtained in the second of two pilot experiments. However, since no further revisions to the analysis plan were made after this pilot, the risk of bias due to prior data observation remains zero, and the manuscript therefore qualifies for Level 6.
 
List of eligible PCI RR-friendly journals:
 
References
 
1. Viviani, E., Ramscar, M. & Wonnacott, E. (2022). Go above and beyond: Does input variability affect children’s ability to learn spatial adpositions in a novel language? In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/37dxr
Go above and beyond: Does input variability affect children’s ability to learn spatial adpositions in a novel language?Eva Viviani1, Michael Ramscar2, Elizabeth Wonnacott1 [1: University of Oxford, 2: University of Tübingen]<p>Human language is characterized by productivity, that is, the ability to use words and structures in novel contexts. How do learners acquire these productive systems? Under a <em>discriminative learning approach,</em> language learning involves...Social sciencesChris Chambers2021-11-15 15:04:42 View
31 Dec 2024
STAGE 1

Allostatic Interoception in Frontotemporal Dementia: A Scoping Review Protocol

What is the evidence for interoceptive and allostatic dysfunction in frontotemporal dementia?

Recommended by ORCID_LOGO based on reviews by Mallory Feldman, Eliza Bliss-Moreau and 1 anonymous reviewer
Frontotemporal dementia (FTD) refers to a range of neurodegenerative diseases involving progressive deterioration of frontal and temporal brain networks. This scoping review protocol by Carneiro et al. (2024) promises to make a valuable contribution to the conceptualization of dysregulated interoception (the ability to sense and interpret internal bodily signals) and allostasis (anticipation and adjustment of energy use in response to environmental demands) in the context of FTD. The work also has broader implications, potentially offering key insights into the interplay between sensory and regulatory signals, which hold relevance not only for dementia but also for other mental disorders characterized by maladaptive allostatic adaptations, such as addiction. This broader applicability underscores the potential impact of the review across multiple domains of mental health research.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on ​detailed responses to reviewers’ and the recommender’s comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.​​​
 
URL to the preregistered Stage 1 protocol: https://osf.io/skebz
 
Level of bias control achieved: Level 2. At least some data/evidence that will be used to answer the research question has been accessed and partially observed by the authors, but the authors certify that they have not yet observed the key variables within the data that will be used to answer the research question.
 
List of eligible PCI-RR-friendly journals:
 
 
References

Carneiro, F., Hazelton, J. L., Campos, C., Ibáñez, A., & Ferreira-Santos, F. (2024). Allostatic interoception in frontotemporal dementia: a scoping review protocol. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/skebz
Allostatic Interoception in Frontotemporal Dementia: A Scoping Review ProtocolFábio Carneiro, Jessica L. Hazelton, Carlos Campos, Agustín Ibáñez, Fernando Ferreira-Santos<p>Frontotemporal dementia (FTD) encompasses a spectrum of disorders characterized by distinct behavioral, cognitive, and motor symptoms. Deficits in interoception and allostasis have garnered attention, considering the involvement of the allostat...Medical SciencesMateo Leganes-Fonteneau2024-03-08 19:37:35 View
14 Nov 2023
STAGE 1

Scrolling to wisdom: the impact of social media news exposure on knowledge perception

Might we know less about current events than we think we do?

Recommended by ORCID_LOGO based on reviews by Adrien Fillon, Erik Løhre and Moritz Ingendahl
​​We are bombarded with news about current events from multiple sources: print media, digital media, friends, family, and more. At the same time, there is an imperative to “stay informed” and be knowledgeable of happenings both local and global. But how much knowledge do we actually gain from this bombardment of information? How informed are we really? It turns out that our perceptions of our knowledge tends to overstate our actual knowledge of a topic. This “illusion of knowledge” effect has been studied across a wide variety of contexts, but is especially relevant for understanding how people learn about and interact with politicized topics.
 
In the current study, Ruzzante et al. (2023) propose to further our understanding of the illusion of knowledge effect in the context of news exposure on social media. They will use an online pre-post experimental design that assesses participants’ perceived knowledge of a number of topics prior to the manipulation, which involves exposure to different social media news feeds, coming two weeks later. Central to the study, participants will be randomized to news stories that differ in their degree of self-involvement, that is how emotionally involved the topics are. Ruzzante et al. will test the hypothesis that more highly self-involved topics (e.g., abortion) will lead to a greater illusion of knowledge effect than less self-involved topics (e.g., feline immunodeficiency).
 
The Stage 1 manuscript was evaluated over two rounds of in-depth peer review, the first consisting of substantial comments from three scholars with relevant expertise, and the second consisting of a close review by the recommender. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and was therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/qa7tb
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Ruzzante, F., Cevolani, G., & Panizza, F. (2023). Scrolling to wisdom: The impact of social media news exposure on knowledge perception. In principle acceptance of Version 5 by Peer Community in Registered Reports. https://osf.io/qa7tb
Scrolling to wisdom: the impact of social media news exposure on knowledge perceptionFederica Ruzzante, Gustavo Cevolani, Folco Panizza<p>The present study aims to test the effect of exposure to news in a social media environment on people’s perceived knowledge of selected topics and on the “illusion of knowledge” effect, i.e., the overestimation of one’s perceived knowledge rela...Social sciencesMoin Syed2022-10-12 21:16:51 View
30 Oct 2023
STAGE 1

The role of spatial location in irrelevant speech revisited: A pre-registered replication

Does auditory stream segregation reduce the irrelevant speech effect?

Recommended by ORCID_LOGO based on reviews by Massimo Grassi and 2 anonymous reviewers
The irrelevant-speech effect (ISE) is a laboratory phenomenon in which performance at memory recall is impaired by the presence of irrelevant auditory stimuli during the initial encoding phase. In a typical ISE experiment, participants are asked to remember a sequence of letters presented visually (e.g. F, K, L, M, Q, R, Y in a shuffled random order between trials) while irrelevant speech is played over headphones. The typical finding is that recall performance is impaired by the presentation of speech compared with silence. The ISE has been influential in cognitive psychology, prompting the advancement of two broad classes of competing explanations: one in which the irrelevant sounds gain automatic access to memory processes without any specified role for attentional selection, and another in which the ISE is explained by irrelevant speech drawing attention away from the relevant items to be recalled.
 
In the current study, Kattner et al. (2023) propose a replication of a seminal study by Jones and Macken (1995) that provided a foundation for the automatic access (or ‘interference-by-process’) class of theories. In their original set of experiments, Jones and Macken reported that the segregating individual components of the irrelevant speech (the spoken letters V, J, and X) into different lateralized locations reduced the magnitude of the ISE by converting a single ‘changing-state’ stream three separate ‘steady-state’ streams. Here, Kattner et al. ask firstly whether this classic finding can be successfully replicated in a well-powered sample, and secondly whether the streaming-by-location effect in Jones and Macken reduces the ISE to the same level as observed during a steady-state baseline condition in which a single letter is repeated from each location. If the answer to either question is No then doubts will have been raised about interference-by-process theories, opening the door (even more) to alternative theoretical explanations of the ISE.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/2tb8e
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 

References
 
1. Jones, D. M. & Macken, W. J. (1995). Organizational factors in the effect of irrelevant speech: The role of spatial location and timing. Memory & Cognition, 23, 192–200. https://doi.org/10.3758/BF03197221 
 
2. Kattner, F., Hassanzadeh, M. & Ellermeier, W. (2023). The role of spatial location in irrelevant speech revisited: A registered replication of Jones and Macken (1995). In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/2tb8e
The role of spatial location in irrelevant speech revisited: A pre-registered replicationFlorian Kattner, Mitra Hassanzadeh, & Wolfgang Ellermeier<p>The goal of the present investigation is to perform a preregistered replication of Jones and Macken’s (1995b) study, which showed that the segregation of a sequence of sounds to distinct spatial locations reduced the detrimental effects of irre...Social sciencesChris Chambers2023-04-26 17:01:57 View
06 Feb 2023
STAGE 1

Investigating the impact of vascular risk factors on the progression of white matter lesions

Understanding predictors of white matter lesions in the human brain

Recommended by ORCID_LOGO based on reviews by Max Elliott, Isabel Garcia Garcia and 1 anonymous reviewer
Cerebral small vessel disease (CSVD) is a common and multi-faceted set of pathologies that affect the small arteries, arterioles, venules and capillaries of the brain. The disease manifests through a range of symptoms and conditions, including psychiatric disorders, abnormal gait, and urinary incontinence, while accounting for 25% of strokes and nearly 50% of dementia.
 
The presence of CSVD is associated with white matter lesions (WML) detected using neuroimaging, which have in turn been shown to predict future stroke, cognitive decline and dementia. While vascular risk factors of CSVD (such as hypertension and obesity) are also associated with CSVD, a complete picture of the predictive relationship between WML, cognitive decline, and blood pressure remains to be determined, as does the role of sex/gender. These inter-relationships are important to determine for improving the diagnosis and treatment of CSVD.
 
In the current study, Beyer et al. will analyse a large emerging dataset from the LIFE-Adult project – a longitudinal, two-wave, population-based study – to ask whether higher blood pressure predicts a greater increase in WML, and whether progression of WML is associated with measures of memory and executive function. In addition, the authors will explore the relationship between abdominal obesity and WML progression, and the extent to which WML progression, and its interaction with vascular risk factors, depends on sex/gender.
 
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/qkbgj
 
Level of bias control achieved: Level 2. At least some data/evidence that will be used to answer the research question has been accessed and partially observed by the authors, but the authors certify that they have not yet observed the key variables within the data that will be used to answer the research question.
 
List of eligible PCI RR-friendly journals:
 
 
References
 
1. Beyer, F., Lammer, L., Loeffler, M., Riedel-Heller, S., Villringer, A. & Witte, V. (2023). Investigating the impact of vascular risk factors on the progression of white matter lesions, in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/qkbgj
Investigating the impact of vascular risk factors on the progression of white matter lesionsFrauke Beyer,Laurenz Lammer, Markus Loeffler, Steffi Riedel-Heller, Arno Villringer, Veronica Witte<p>Cerebral small vessel disease (cSVD) is a major brain pathology contributing to cognitive decline and dementia. Vascular risk factors have been associated with imaging markers of cSVD such as white matter lesions, yet longitudinal studies have ...Life SciencesChris Chambers Isabel Garcia Garcia, Max Elliott2022-10-07 13:44:11 View