In the past two decades, most academic fields have witnessed an open science revolution that has led to significant increases in open access publishing, reproducibility efforts, and scientific transparency in general (e.g., Spellman et al. 2018). One of the key areas in this ongoing change is data sharing. Although some evidence already points at progress in data sharing practices, many new datasets remain unshared (see Tedersoo et al. 2021).
 
In the present registered report, Henderson et al. (2023) empirically explore the factors that either hinder or facilitate data sharing in the UK. By means of semi-structured interviews, the team will chart researchers’ experiences of sharing and non-sharing. Thematic template analysis will be applied to organise the data into a hierarchical map of capabilities, opportunities, and motivations in a theoretical domains framework (COM-B-TDF). The research plan itself meets the highest open science standards and reflects on the authors own positions, from which the current qualitative interview data sharing efforts will be made.
 
The Stage 1 manuscript was reviewed over three rounds by three experts with familiary of the UK cultural context and specializations in open science practices, qualitative research, and data infrastructures. Based on careful revisions and detailed responses to the reviewers’ comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance.
 
URL to the preregistered Stage 1 protocol: https://osf.io/2gm5s (under temporary private embargo)
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.  
 
List of eligible PCI RR-friendly journals:

 

 

References
 
1. Henderson, E., Marcu, A., Atkins, L. & Farran, E.K. (2023). Investigating the barriers and enablers to data sharing behaviours: A qualitative Registered Report. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/2gm5s

 

2. Spellman, B. A., Gilbert, E. A. & Corker, K. S. (2018). Open Science. Stevens' Handbook of Experimental Psychology and Cognitive Neuroscience, 5, 1-47. https://doi.org/10.1002/9781119170174.epcn519

 

3. Tedersoo, L., Küngas, R., Oras, E., Köster, K., Eenmaa, H., Leijen, Ä., ... & Sepp, T. (2021). Data sharing practices and data availability upon request differ across scientific disciplines. Scientific data, 8, 192. https://doi.org/10.1038/s41597-021-00981-0

Single gene alterations have been estimated to account for nearly half of neurodevelopmental conditions (NDCs), providing a crucial opportunity for animal models to understand the underlying mechanisms, causes and potential treatments. The use of systematic reviews (SRs) can, in principle, provide a powerful means to synthesise this evidence-base; however, the reporting quality of previous SRs in preclinical animal research has been found lacking (Hunniford et al., 2021). In the current study, Wilson et al. (2023) will undertake an umbrella review – a systematic review of systematic reviews – to assess the characteristics and reporting quality of SRs that, in turn, synthesise research in genetically-modified animals to model NDCs. In particular, the authors will extract key features of reviews (including, among others, the aim and primary research questions, relevant animal model, and number of studies in the SR), in addition to quality indicators such as risk of bias and completeness of reporting. In doing so, the authors aim to enhance guidance on the conduct and reporting of systematic reviews in this area.

 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/952qk

 

Level of bias control achieved: Level 4. At least some of the data/evidence that will be used to answer the research question already exists AND is accessible in principle to the authors BUT the authors certify that they have not yet accessed any part of that data/evidence.

 
List of eligible PCI RR-friendly journals:

 

 

1. Hunniford V. T., Montroy J., Fergusson D. A., Avey M. T., Wever K. E., McCann S. K., Foster M., Fox G., Lafreniere M., Ghaly M., Mannell S., Godwinska K., Gentles A., Selim S., MacNeil J., Sikora L., Sena E. S., Page M. J., Macleod M., Moher D., & Lalu M. M. (2021). Epidemiology and reporting characteristics of preclinical systematic reviews. PLOS Biology, 19:e3001177. https://doi.org/10.1371/journal.pbio.3001177

 

2. Wilson, E., Currie, G., Macleod, M., Kind, P. & Sena, E. S. (2023). Genetically-modified animals as models of neurodevelopmental conditions: an umbrella review, in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/952qk

One of the major challenges in studies of language learning is understanding productive generalisation – the ability to use words and linguistic structures in novel settings that the learner has never encountered previously. According to discriminative learning theory, this skill arises from an iterative process of prediction and error-correction that gradually reduces uncertainty, allowing learners to discriminate linguistic outcomes and to identify informative, invariant cues for generalisation to novel cases. In the current study, Viviani et al (2022) use computational modelling to propose a central hypothesis stemming from this theory that children will learn the meaning and use of spatial adpositions (words such as “above” and “below” that describe relative positions) more effectively when there is more variability in the use of the nouns within the spatial sentences. They will also test a range of additional hypotheses, including that learning and generalisation to novel contexts will be enhanced when children learn from skewed distributions that are similar to those found in natural languages.

 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
 
URL to the preregistered Stage 1 protocol: https://osf.io/37dxr

 

Level of bias control achieved: Level 6. Some of the data that will be used in the preregistered analyses was obtained in the second of two pilot experiments. However, since no further revisions to the analysis plan were made after this pilot, the risk of bias due to prior data observation remains zero, and the manuscript therefore qualifies for Level 6.
 
List of eligible PCI RR-friendly journals:

 

 

1. Viviani, E., Ramscar, M. & Wonnacott, E. (2022). Go above and beyond: Does input variability affect children’s ability to learn spatial adpositions in a novel language? In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/37dxr

The irrelevant-speech effect (ISE) is a laboratory phenomenon in which performance at memory recall is impaired by the presence of irrelevant auditory stimuli during the initial encoding phase. In a typical ISE experiment, participants are asked to remember a sequence of letters presented visually (e.g. F, K, L, M, Q, R, Y in a shuffled random order between trials) while irrelevant speech is played over headphones. The typical finding is that recall performance is impaired by the presentation of speech compared with silence. The ISE has been influential in cognitive psychology, prompting the advancement of two broad classes of competing explanations: one in which the irrelevant sounds gain automatic access to memory processes without any specified role for attentional selection, and another in which the ISE is explained by irrelevant speech drawing attention away from the relevant items to be recalled.

 

In the current study, Kattner et al. (2023) propose a replication of a seminal study by Jones and Macken (1995) that provided a foundation for the automatic access (or ‘interference-by-process’) class of theories. In their original set of experiments, Jones and Macken reported that the segregating individual components of the irrelevant speech (the spoken letters V, J, and X) into different lateralized locations reduced the magnitude of the ISE by converting a single ‘changing-state’ stream three separate ‘steady-state’ streams. Here, Kattner et al. ask firstly whether this classic finding can be successfully replicated in a well-powered sample, and secondly whether the streaming-by-location effect in Jones and Macken reduces the ISE to the same level as observed during a steady-state baseline condition in which a single letter is repeated from each location. If the answer to either question is No then doubts will have been raised about interference-by-process theories, opening the door (even more) to alternative theoretical explanations of the ISE.
 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).

 

URL to the preregistered Stage 1 protocol: https://osf.io/2tb8e
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 

 

1. Jones, D. M. & Macken, W. J. (1995). Organizational factors in the effect of irrelevant speech: The role of spatial location and timing. Memory & Cognition, 23, 192–200. https://doi.org/10.3758/BF03197221 

 
2. Kattner, F., Hassanzadeh, M. & Ellermeier, W. (2023). The role of spatial location in irrelevant speech revisited: A registered replication of Jones and Macken (1995). In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/2tb8e

Cerebral small vessel disease (CSVD) is a common and multi-faceted set of pathologies that affect the small arteries, arterioles, venules and capillaries of the brain. The disease manifests through a range of symptoms and conditions, including psychiatric disorders, abnormal gait, and urinary incontinence, while accounting for 25% of strokes and nearly 50% of dementia.

 

The presence of CSVD is associated with white matter lesions detected as white matter hyperintensities (WMH) using neuroimaging, which have in turn been shown to predict future stroke, cognitive decline and dementia. While vascular risk factors of CSVD (such as hypertension and obesity) are also associated with CSVD, a complete picture of the predictive relationship between WMH, cognitive decline, and blood pressure remains to be determined, as does the role of sex/gender. These inter-relationships are important to determine for improving the diagnosis and treatment of CSVD.

 

In the current study, Beyer et al. analysed a large emerging dataset from the LIFE-Adult project – a longitudinal, two-wave, population-based study – to ask whether higher blood pressure predicts a greater increase in WMH, and whether progression of WMH is associated with measures of memory and executive function. In addition, the authors explored the relationship between abdominal obesity and WMH progression, and the extent to which WMH progression, and its interaction with vascular risk factors, depends on sex/gender.

 

Results revealed no reliable association between baseline blood pressure with WMH progression. WMH progression significantly predicted global cognitive decline but not decline in executive function specifically. Exploratory analyses revealed that increases in diastolic blood pressure as well as baseline and systolic blood pressure were associated with WMH progression, specifically in frontal periventricular regions, but there was no association of waist-to-hip ratio (a proxy of abdominal fat deposits) with WMH progression nor any gender-specific associations. The authors conclude that strict control of blood pressure might confer a protective effect, limiting WMH progression and negative effects on global cognitive function in the middle-aged to older population.

 

The Stage 2 manuscript was evaluated over one round of in-depth review. Based on responses to the reviewer's comments, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
 
URL to the preregistered Stage 1 protocol: https://osf.io/qkbgj

 

Level of bias control achieved: Level 2. At least some data/evidence that was used to answer the research question had been accessed and partially observed by the authors prior to Stage 1 in-principle acceptance, but the authors certify that they had not yet observed the key variables within the data that were used to answer the research question.

 
List of eligible PCI RR-friendly journals:

 

• Brain and Neuroscience Advances
• Cortex
• F1000Research
• Imaging Neuroscience
• In&Vertebrates
• NeuroImage: Reports
• Peer Community Journal
• PeerJ
• Royal Society Open Science
   

 

 

1. Beyer, F., Lammer, L., Loeffler, M., Riedel-Heller, S., Debette, S., Villringer, A. & Witte, A. V. (2023). Progression of white matter hyperintensities is related to blood pressure increases and global cognitive decline – a registered report [Stage 2]. Acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/k24pm