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Latest recommendations
Id | Title * ▼ | Authors * | Abstract * | Picture | Thematic fields * | Recommender | Reviewers | Submission date | |
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05 Jun 2024
STAGE 1
![]() Revisiting Partition Priming in judgment under uncertainty: Replication and extension Registered Report of Fox and Rottenstreich (2003)Kerou Ding, Gilad Feldman https://osf.io/s2dvcUnderstanding probability assessments with partitioned framingRecommended by Romain EspinosaDecision-making based on limited information is a common occurrence. Whether it is the possibility of a cheaper product elsewhere or the unknown qualifications of election candidates, people are regularly forced to make a decision under ignorance or uncertainty. In such situations, information about certain events is unavailable or too costly to acquire and people rely on subjective probability allocation to guide decision-making processes. This allocation seems to result in what is known as ignorance priors, i.e., decision-makers assigning equal probabilities to each possible outcome within a given set. How events are grouped or partitioned is often subjective and may influence probability judgments and subsequent decisions. In such cases, the way the choices within a choice set are presented may shape the perceived likelihood of different outcomes. Understanding the impact of partitioning on probability estimation is crucial for both psychological and economic theories of judgment and decision.
The question of evaluating probabilities under uncertainty has received much attention in the psychology and economics literature over the past decades given the wide range of possible applications. In the current work, Ding and Feldman (2024) seek to replicate one of the foundational works on the topic: Fox and Rottenstreich (2003). In the original work, the authors provided exploratory evidence indicating that the framing of a situation affects the way individuals perceive probabilities of possible outcomes. They showed that people assigned uniform probabilities to sets of events described in a problem, such that the way the events are described partly determines people’s partitioning of those events and evaluations of the probabilities of the possible outcomes. Additionally, this partitioned framing affected judgments both under conditions of ignorance (where individuals have no information and rely solely on uniform probability assignments) and uncertainty (where individuals have some information but still rely on heuristics influenced by partitioning). This suggests that priors resulting from the inference of available evidence are sometimes partly contaminated by partitioning bias, affecting both uninformed and partially informed decision-making processes. As a consequence, the partitioning of events into different subsets might lead to varying evaluations of a single situation, resulting in inconsistencies and poorly calibrated probability assessments.
Ding and Feldman (2024) aim to replicate Studies 1a, 1b, 3, and 4 from Fox and Rottenstreich (2003). Their close replication will rely on original data (US participants, Prolific, N=600, not collected yet) with a large statistical power (>95%). Their replication aims to examine whether the partitioned framing affects prior formation under ignorance (Studies 1a, 1b, and 4) and uncertainty (Study 3). In addition, the authors propose an extension examining estimations of alternative event(s) contrasting estimations of the probabilities of events happening versus of events not happening.
The Stage 1 manuscript was evaluated by two external reviewers and the recommender. Based on detailed responses to the reviewers' and the recommender’s comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/px6vb
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals:
References
1. Ding, K. & Feldman, G. (2024). Revisiting Partition Priming in judgment under uncertainty:
Replication and extension Registered Report of Fox and Rottenstreich (2003). In principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/px6vb 2. Fox, C. R. & Rottenstreich, Y. (2003). Partition priming in judgment under uncertainty. Psychological Science, 14, 195-200. https://doi.org/10.1111/1467-9280.02431
| Revisiting Partition Priming in judgment under uncertainty: Replication and extension Registered Report of Fox and Rottenstreich (2003) | Kerou Ding, Gilad Feldman | <p>[IMPORTANT: Abstract, method, and results were written using a randomized dataset produced by Qualtrics to simulate what these sections will look like after data collection. These will be updated following the data collection. For the purpose o... | Social sciences | Romain Espinosa | 2024-01-18 12:46:26 | View | ||
17 May 2022
STAGE 1
![]() Revisiting mental accounting classic paradigms: Replication of Thaler (1999) and an extension examining impulsivityMengfei Li; Gilad Feldman https://osf.io/4ps8m/Mental accounting under the microscopeRecommended by Chris ChambersIn recent years, the study of mental accounting – the thought processes by which people informally record, categorise, and evaluate the costs and benefits of their financial transactions – has been an active research area, drawing attention to a range of biases and distortions that deviate from optimal economic decision-making (Zhang & Sussman, 2018). Although the term “mental accounting” is a relatively recent construction (Thaler, 1999), it stems from a longer history of behavioural economic research on value functions, decision frames, risk-taking, and related concepts.
In the current study, Li and Feldman propose to replicate 17 influential mental accounting problems (or tasks) reviewed by Thaler (1999) in a large online sample. The authors also propose several extensions examining the effects of sunk costs and expenses framing.
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/d6cjk
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals:
References
1. Zhang, C. Y., & Sussman, A. B. (2018). Perspectives on mental accounting: An exploration of budgeting and investing. Financial Planning Review, 1, e1011. https://doi.org/10.1002/cfp2.1011
2. Thaler, R. H. (1999). Mental accounting matters. Journal of Behavioral Decision Making, 12, 183-206. https://doi.org/10.1002/(SICI)1099-0771(199909)12:3%3C183::AID-BDM318%3E3.0.CO;2-F
3. Li, M. & Feldman, G. (2022). Revisiting mental accounting classic paradigms: Replication of the problems reviewed in Thaler (1999), in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/d6cjk
| Revisiting mental accounting classic paradigms: Replication of Thaler (1999) and an extension examining impulsivity | Mengfei Li; Gilad Feldman | <p>This is a scheduled PCI-RR snap shot for a planned project: "Revisiting mental accounting classic paradigms: Replication of Thaler (1999) and an extension examining impulsivity"</p> | Social sciences | Chris Chambers | 2022-01-31 10:18:38 | View | ||
09 Jun 2022
STAGE 1
![]() Revisiting diversification bias and partition dependence: Replication and extensions of Fox, Ratner, and Lieb (2005) Studies 1, 2, and 5Mei Yee (Alice) Li, Gilad Feldman https://osf.io/vkp3q/Testing the replicability of diversification bias and partition dependenceRecommended by Chris ChambersWhen offered a range of options and asked to make multiple selections, how do people choose? Over the last 30 years, a key finding to emerge from behavioural economics is that people distribute their choices more evenly than would be considered optimal – a phenomenon termed “diversification bias” or the “diversification heuristic” (Read & Loewenstein, 1995). For example, when filling a plate from a buffet, you might be inclined to choose a relatively even amount of everything on offer, even when you prefer some foods over others. Similarly, when allocating savings among different investment options, people are prone to spreading their money more evenly than would maximise utility.
In an influential study, Fox et al. (2005) found that diversification bias can be shaped by so-called “partition dependence” – the tendency to allocate resources differently across options depending on how they are subjectively grouped. Such groupings could be arbitrary; so, for example, to return to the buffet example, people might diversify across high-level categories such as cooked and uncooked, savoury and sweet, or surf and turf, and then diversify across the options within those categories. The nature of level of these subjective (and potentially arbitrary) categorisations can strongly influence the final allocation of resources. Diversification bias and partition dependence have important implications for basic theory in judgment and decision-making as well as applications in behavioral economics and finance.
In the current study, Li and Feldman (2022) propose to replicate Studies 1, 2 and 5 from Fox et al. (2002) in a large online sample. In particular, they plan to ask how partitioning influences the allocation of choices between options, and the extent to which partition dependence is reduced in people with greater relevant expertise. The authors also propose extending the original study to explore individual differences in the desire for choice diversity as predictors of partition dependence.
The Stage 1 manuscript was evaluated over one round of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/bx8vq Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals: References 1. Read, D., & Loewenstein, G. (1995). Diversification bias: Explaining the discrepancy in variety seeking between combined and separated choices. Journal of Experimental Psychology: Applied, 1, 34-49. https://doi.org/10.1037/1076-898X.1.1.34
2. Fox, C. R., Ratner, R. K., & Lieb, D. S. (2005). How subjective grouping of options influences choice and allocation: Diversification bias and the phenomenon of partition dependence. Journal of Experimental Psychology: General, 134, 538-551. https://doi.org/10.1037/0096-3445.134.4.538
3. Li, M. Y. & Feldman, G. (2022). Revisiting diversification bias and partition dependence: Replication and extension of Fox, Ratner, and Lieb (2005) Studies 1, 2, and 5, in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/bx8vq | Revisiting diversification bias and partition dependence: Replication and extensions of Fox, Ratner, and Lieb (2005) Studies 1, 2, and 5 | Mei Yee (Alice) Li, Gilad Feldman | <p>This is a scheduled PCI-RR snap shot for a planned project: "Revisiting diversification bias and partition dependence: Replication and extensions of Fox, Ratner, and Lieb (2005) Studies 1, 2, and 5 "</p> | Social sciences | Chris Chambers | Leo Cohen, Craig Fox | 2022-02-15 09:57:51 | View | |
30 Jun 2022
STAGE 1
![]() Revisiting and updating the risk-benefits link: Replication of Fischhoff et al. (1978) with extensions examining pandemic related factorsJason M. Frank, Gilad Feldman https://osf.io/zayn3Understanding the relationship between the perception of risks and benefitsRecommended by Chris ChambersEveryday decisions involve weighing up many kinds of risks and benefits, prompting the question of how our perception of those risks relates to our perception of the associated benefits. Intuitively, we might assume that behaviours or practices that are judged by society as riskier would also be seen as carrying greater potential benefits, in keeping with the expression “high risk, high reward”. The psychology of risk perception, however, appears to be more complex. In a seminal study, Fischhoff et al. (1978) in fact found the opposite pattern: that perceived risk and perceived benefit were negatively correlated – behaviours or practices that were perceived to be higher risk tended to be perceived as carrying lower benefits. This counterintuitive finding has had a significant impact on the field of judgment and decision making, despite being subjected only rarely to close replication.
Using a large-scale online design, Frank and Feldman (2022) propose a replication that incorporates key elements of Fischhoff et al. (1978) as well as a recent replication by Fox-Glassman et al. (2016). In particular, the authors will reassess the strength and directionality of the relationship between perceived risks and perceived benefits, and how these relate to both risk characteristics and acceptable levels of risk. As part of a series of exploratory extensions, they will also examine the risk/benefit relationship for policies and practices related to the Covid-19 pandemic, including vaccinations, lockdowns, and social distancing.
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/bx93v Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals:
References
1. Fischhoff, B., Slovic, P., Lichtenstein, S., Read, S., & Combs, B. (1978). How safe is safe enough? A psychometric study of attitudes towards technological risks and benefits. Policy Sciences, 9, 127-152. https://doi.org/10.1007/BF00143739
2. Fox-Glassman, K. T. & Weber, E. U. (2016). What makes risk acceptable? Revisiting the 1978 psychological dimensions of perceptions of technological risks. Journal of Mathematical Psychology, 75, 157-169. https://doi.org/10.1016/j.jmp.2016.05.003
3. Frank, J. M. & Feldman, G. (2022). Revisiting and updating the risk-benefits link: Replication of Fischhoff et al. (1978) with extensions examining pandemic related factors, in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/bx93v
| Revisiting and updating the risk-benefits link: Replication of Fischhoff et al. (1978) with extensions examining pandemic related factors | Jason M. Frank, Gilad Feldman | <p>This is a scheduled PCI-RR snap shot for a planned project: "Revisiting and updating the risk-benefits link: Replication of Fischhoff et al. (1978) with extensions examining pandemic related factors "</p> | Social sciences | Chris Chambers | 2022-02-15 09:21:15 | View | ||
14 Feb 2024
STAGE 1
![]() Restriction of researcher degrees of freedom through the Psychological Research Preregistration-Quantitative (PRP-QUANT) TemplateLisa Spitzer & Stefanie Mueller https://doi.org/10.23668/psycharchives.14119Examining the restrictiveness of the PRP-QUANT TemplateRecommended by Daniel LakensThe Psychological Research Preregistration-Quantitative Template has been created in 2022 to provide more structure and detail to preregistrations. The goal of the current study is to test if the PRP-QUANT template indeed provides greater restriction of the flexibility in a study for preregistered hypotheses than other existing templates. This question is important because one concern that has been raised about the practice of preregistration is that the quality of preregistrations is often low. Metascientific research has shown that preregistrations are often of low quality (Bakker et al., 2020), and hypothesis tests from preregistrations are still selectively reported (van den Akker, van Assen, Enting, et al., 2023). It is important to improve the quality of preregistrations, and if a better template can help, it is a cost-effective approach to improve quality if the wider adoption of the better template can be promoted.
In the current study, Spitzer and Mueller (2024) will follow the procedure of a previous meta-scientific study by Heirene et al. (2021). 74 existing preregistrations with the PRP-QUANT template are available, and will be compared with an existing dataset coded by Bakker and colleagues (2020). The sample size is limited, but allows detecting some differences that would be considered large enough to matter, even though there might be smaller differences that would not be detectable based on the currently available sample size. Nevertheless, given that there is a need for improvement, even preliminary data might already be useful to provide tentative recommendations. Restrictiveness will be coded in 23 items, and adherence to or deviations from the preregistration are coded as well. As such deviations are common, the question whether this template reduced the likelihood of deviations is important. Two coders will code all studies.
The study should provide a useful initial evaluation of the PRP-QUANT template, and has the potential to have practical implications if the PRP-QUANT template shows clear benefits. Both authors have declared COI's related to the PRP-QUANT template, making the Registered Report format a fitting approach to prevent confirmation bias from influencing the reported results.
This Stage 1 manuscript was evaluated over two rounds of in-depth review by two expert reviewers and the recommender. After the revisions, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/vhezj
Level of bias control achieved: Level 3. At least some data/evidence that will be used to the answer the research question has been previously accessed by the authors (e.g. downloaded or otherwise received), but the authors certify that they have not yet observed ANY part of the data/evidence. List of eligible PCI RR-friendly journals:
References
1. van den Akker, O. R., van Assen, M. A. L. M., Bakker, M., Elsherif, M., Wong, T. K., & Wicherts, J. M. (2023). Preregistration in practice: A comparison of preregistered and non-preregistered studies in psychology. Behavior Research Methods. https://doi.org/10.3758/s13428-023-02277-0
2. Bakker, M., Veldkamp, C. L. S., Assen, M. A. L. M. van, Crompvoets, E. A. V., Ong, H. H., Nosek, B. A., Soderberg, C. K., Mellor, D., & Wicherts, J. M. (2020). Ensuring the quality and specificity of preregistrations. PLOS Biology, 18(12), e3000937. https://doi.org/10.1371/journal.pbio.3000937
3. Spitzer, L. & Mueller, S. (2024). Stage 1 Registered Report: Restriction of researcher degrees of freedom through the Psychological Research Preregistration-Quantitative (PRP-QUANT) Template. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/vhezj
4. Heirene, R., LaPlante, D., Louderback, E. R., Keen, B., Bakker, M., Serafimovska, A., & Gainsbury, S. M. (2021). Preregistration specificity & adherence: A review of preregistered gambling studies & cross-disciplinary comparison. PsyArXiv. https://doi.org/10.31234/osf.io/nj4es
| Restriction of researcher degrees of freedom through the Psychological Research Preregistration-Quantitative (PRP-QUANT) Template | Lisa Spitzer & Stefanie Mueller | <p>Preregistration can help to restrict researcher degrees of freedom and thereby ensure the integrity of research findings. However, its ability to restrict such flexibility depends on whether researchers specify their study plan in sufficient de... | ![]() | Social sciences | Daniel Lakens | 2023-06-01 10:39:20 | View | |
23 Jan 2023
STAGE 1
![]() Responding to Online Toxicity: Which Strategies Make Others Feel Freer to Contribute, Believe That Toxicity Will Decrease, and Believe that Justice Has Been Restored?Alison I. Young Reusser, Houghton University; Kristian Veit, Olivet Nazarene University; Lisa Gassin, Olivet Nazarene University; Jonathan Case, Houghton University https://osf.io/hfjnbTesting antidotes to online toxicityRecommended by Chris ChambersSocial media is a popular tool for online discussion and debate, bringing with it various forms of hostile interactions – from offensive remarks and insults, to harassment and threats of physical violence. The nature of such online toxicity has been well studied, but much remains to be understood regarding strategies to reduce it. Existing theory and evidence suggests that a range of responses – including those that emphasise prosociality and empathy – might be effective at mitigating online toxicity. But do such strategies work in practice?
In the current study, Young Reusser et al (2023) propose an experiment to test the effectiveness of three types of responses to online toxicity – Benevolent Correction (including disagreement), Benevolent Going Along (including joking/agreement), or Retaliation (additional toxicity) – on how able participants feel to contribute to conversations, their belief that the toxicity would be reduced by the intervention, and their belief that justice had been restored. The findings promise to shed light on approaches for improving the health of online discourse.
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/hfjnb (under temporary private embargo) Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals: References
1. Young Reusser, A. I., Veit, K. M., Gassin, E. A., & Case, J. P. (2023). Responding to Online Toxicity: Which Strategies Make Others Feel Freer to Contribute, Believe That Toxicity Will Decrease, and Believe that Justice Has Been Restored? In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/hfjnb
| Responding to Online Toxicity: Which Strategies Make Others Feel Freer to Contribute, Believe That Toxicity Will Decrease, and Believe that Justice Has Been Restored? | Alison I. Young Reusser, Houghton University; Kristian Veit, Olivet Nazarene University; Lisa Gassin, Olivet Nazarene University; Jonathan Case, Houghton University | <p>When we encounter toxic comments online, how might individual efforts to reply to those comments improve others’ experiences conversing in that forum? Is it more helpful for others to publicly, but benevolently (with a polite tone, demonstrated... | Social sciences | Chris Chambers | 2022-06-08 18:35:48 | View | ||
Responding to Online Toxicity: Which Strategies Make Others Feel Freer to Contribute, Believe That Toxicity Will Decrease, and Believe that Justice Has Been Restored?Alison I. Young Reusser, Kristian M. Veit, Elizabeth A. Gassin, and Jonathan P. Case https://osf.io/k46e8Benevolent correction may provide a promising antidote to online toxicityRecommended by Chris ChambersSocial media is a popular tool for online discussion and debate, bringing with it various forms of hostile interactions – from offensive remarks and insults, to harassment and threats of physical violence. The nature of such online toxicity has been well studied, but much remains to be understood regarding strategies to reduce it. Existing theory and evidence suggests that a range of responses – including those that emphasise prosociality and empathy – might be effective at mitigating online toxicity. But do such strategies work in practice?
In the current study, Young Reusser et al (2023) tested the effectiveness of three types of responses to online toxicity – benevolent correction (including disagreement), benevolent going along (including joking/agreement) and retaliation (additional toxicity) – on how able participants feel to contribute to conversations, their belief that the toxicity would be reduced by the intervention, and their belief that justice had been restored.
The results showed the benevolent correction – while an uncommon strategy in online communities – was most effective in helping participants feel freer to contribute to online discussions. Benevolent correction was also the preferred approach for discouraging toxicity and restoring justice. Overall, the findings suggest that responding to toxic commenters with empathy and understanding while (crucially) also correcting their toxicity may be an effective intervention for bystanders seeking to improve the health of online interaction. The authors note that future research should focus on whether benevolent correction actually discourages toxicity, which wasn't tested in the current experiment, and if so how the use of benevolent corrections might be encouraged.
Following one round of review and revisions, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/hfjnb Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA.
List of eligible PCI RR-friendly journals:
References
1. Young Reusser, A. I., Veit, K. M., Gassin, E. A., & Case, J. P. (2023). Responding to Online Toxicity:
Which Strategies Make Others Feel Freer to Contribute, Believe That Toxicity Will Decrease, and Believe that Justice Has Been Restored? [Stage 2 Registered Report] Acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/k46e8 | Responding to Online Toxicity: Which Strategies Make Others Feel Freer to Contribute, Believe That Toxicity Will Decrease, and Believe that Justice Has Been Restored? | Alison I. Young Reusser, Kristian M. Veit, Elizabeth A. Gassin, and Jonathan P. Case | <p>When we encounter toxic comments online, how might individual efforts to reply to those comments improve others’ experiences conversing in that forum? Is it more helpful for others to publicly, but benevolently (with a polite tone, demonstrated... | Social sciences | Chris Chambers | 2023-08-02 05:30:37 | View | ||
11 Sep 2023
STAGE 1
![]() Researcher Predictions of Effect Generalizability Across Global SamplesKathleen Schmidt, Priya Silverstein, & Christopher R. Chartier https://osf.io/ygbr5?view_only=348484e6e86442e5a43e75e0cf9aa310Can psychology researchers predict which effects will generalise across cultures?Recommended by Chris ChambersCompared to the wealth of debate surrounding replicability and transparency, relatively little attention has been paid to the issue of generalisability – the extent to which research findings hold across different samples, cultures, and other parameters. Existing research suggests that researchers in psychology are prone to generalisation bias, relying on narrow samples (e.g. drawn predominantly from US or European undergraduate samples) to draw broad conclusions about the mind and behaviour. While recent attempts to address generalisability concerns have been made – such as journals requiring explicit statements acknowledging constraints on generality – addressing this bias at root, and developing truly generalisable methods and results, requires a deeper understanding of how researchers perceive generalisability in the first place.
In the current study, Schmidt et al. (2023) tackle the issue of cross-cultural generalisability using four large-scale international studies that are being conducted as part of the Psychological Science Accelerator (PSA) – a globally distributed network of researchers in psychology that coordinates crowdsourced research projects across six continents. Specifically, participants (who will be PSA research members) will estimate the probability that an expected focal effect will be observed both overall and within regional subsamples of the PSA studies. They will also predict the size of these focal effects overall and by region.
Using this methodology, the authors plan to ask two main questions: first whether researchers can accurately predict the generalisability of psychological phenomena in upcoming studies, and second whether certain researcher characteristics (including various measures of expertise, experience, and demographics) are associated with the accuracy of generalisability predictions. Based on previous evidence that scientists can successfully predict the outcomes of research studies, the authors expect to observe a positive association between predicted and actual outcomes and effect sizes. In secondary analyses, the authors will also test if researchers can predict when variables that capture relevant cultural differences will moderate the focal effects – if so, this would suggest that at least some researchers have a deeper understanding as to why the effects generalise (or not) across cultural contexts.
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/vwqsa (under temporary private embargo)
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References
1. Schmidt, K., Silverstein, P. & Chartier, C. R. (2023). Registered Report: Researcher Predictions of Effect Generalizability Across Global Samples. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/vwqsa
| Researcher Predictions of Effect Generalizability Across Global Samples | Kathleen Schmidt, Priya Silverstein, & Christopher R. Chartier | <p>The generalizability of effects is an increasing concern among researchers in psychological science. Traditionally, the field has relied on university samples from Europe and North America to make claims about humans writ large. The proposed re... | Social sciences | Chris Chambers | 2023-02-16 03:49:35 | View | ||
31 May 2024
STAGE 1
![]() Representativeness heuristic in intuitive predictions: Replication Registered Report of problems reviewed in Kahneman and Tversky (1973)Hong Ching (Bruce) Chan, Gilad Feldman https://osf.io/9cqp6The Representativeness Heuristic Revisited: Registered Replication Report of Kahneman and Tversky (1973)Recommended by Rima-Maria RahalRevisiting a true classic, this registered replication report addresses Kahneman and Tversky’s (1973) introduction of the representativeness heuristic. The heuristic refers to deviations of judgments from normative evaluations of the evidence when the stimulus fits to a prototype. For instance, when an individual is described by features stereotypically associated with a certain target group (e.g., a person who attends dance training several times a week and has a passion for singing and performing), likelihood judgments that the individual belongs to a target group (K-Pop artists) compared to a non-target group (e.g., accountants) are inflated.
The impact of the original research on the field is clearly immense and long-lasting. All the better that a systematic replication attempt is being undertaken in this registered report, which addresses studies 1 through 7 of Kahneman and Tversky’s classic 1973 paper. Chan and Feldman (2024) propose a well-powered online study, in which all studies from the original article are presented to participants within-subjects. The materials are carefully constructed and closely documented in the accompanying OSF project, where in-depth information on planned data analyses is supported with a simulated dataset. The Stage 1 manuscript was evaluated over three rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA). URL to the preregistered Stage 1 protocol: https://osf.io/er2cq
Level of bias control achieved: Level 6. Data collection commenced during the later part of Stage 1 peer review; however, since no substantive changes to the design were made after this point, the risk of bias due to prior data observation remains zero and the manuscript therefore qualifies for Level 6.
List of eligible PCI RR-friendly journals:
References
1. Chan, H. C. & Feldman, G. (2024). Representativeness heuristic in intuitive predictions: Replication Registered Report of problems reviewed in Kahneman and Tversky (1973). In principle acceptance of Version 5 by Peer Community in Registered Reports. https://osf.io/er2cq 2. Kahneman, D., & Tversky, A. (1973). On the psychology of prediction. Psychological Review, 80(4), 237–251. https://doi.org/10.1037/h0034747
| Representativeness heuristic in intuitive predictions: Replication Registered Report of problems reviewed in Kahneman and Tversky (1973) | Hong Ching (Bruce) Chan, Gilad Feldman | <p>[IMPORTANT: Abstract, method, and results were written using a randomized dataset produced by Qualtrics to simulate what these sections will look like after data collection. These will be updated following the data collection. For the purpose o... | Social sciences | Rima-Maria Rahal | 2023-11-29 15:19:07 | View | ||
22 Jul 2024
STAGE 1
![]() Replication of “Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions”Maha Said, Mustafa Gharib, Samia Zrig, Raphaël Lévy https://osf.io/kf9qe/Replicating, Revising and Reforming: Unpicking the Apparent Nanoparticle Endosomal Escape ParadoxRecommended by Emily Linnane and Yuki YamadaContext
Over the past decade there has been an exponential increase in the number of research papers utlising nanoparticles for biological applications such as intracellular sensing [1, 2], theranostics [3-5] and more recently drug delivery and precision medicine [6, 7]. Despite the success stories, there is a disconnect regarding current dogma on issues such as nanoparticle uptake and trafficking, nanoparticle delivery via the enhanced permeability and retention (EPR) effect, and endosomal escape. Critical re-evaluation of these concepts both conceptually and experimentally is needed for continued advancement in the field.
For this preregistration, Said et al. (2024) focus on nanoparticle intracellular trafficking, specifically endosomal escape [8]. The current consensus in the literature is that nanoparticles enter cells via endocytosis [9, 10] but reportedly just 1-2% of nanoparticles/ nanoparticle probes escape endosomes and enter the cytoplasm [11-13]. There is therefore an apparent paradox over how sensing nanoparticles can detect their intended targets in the cytoplasm if they are trapped within the cell endosomes. To address this fundamental issue of nanoparticle endosomal escape, Lévy and coworkers are carrying out replication studies to thoroughly and transparently replicate the most influential papers in the field of nanoparticle sensing. The aim of these replication studies is twofold: to establish a robust methodology to study endosomal escape of nanoparticles, and to encourage discussions, transparency and a step-change in the field.
Replication of “Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions”
For this replication study, the authors classified papers on the topic of nanoparticle sensing and subsequently ranked them by number of citations. Based on this evaluation they selected a paper by Zhu and colleagues [14] entitled “Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions” for their seminal replication study. To determine the reproducibility of the results from Zhu et al., the authors aim to establish the proportion of endosomal escape of the nanoparticles, and to examine the data in a biological context relevant to the application of the probe.
Beyond Replication
The authors plan to replicate the exact conditions reported in the materials and methods section of the selected paper such as nanoparticle probe synthesis of CdSe@C-TPEA nanoparticles, assessment of particle size, stability and reactivity and effect on cells (TEM, pH experiments, fluorescent responsivity to metal ions and cell viability). In addition, Said et al., plan to include further experimental characterisation to complement the existing study by Zhu and colleagues. They will incorporate additional controls and methodology to determine the intracellular location of nanoparticle probes in cells including: quantifying excess fluorescence in the culture medium, live cell imaging analysis, immunofluorescence with endosomal and lysosomal markers, and electron microscopy of cell sections. The authors will also include supplementary viability studies to assess the impact of the nanoparticles on HeLa cells as well as an additional biologically relevant cell line (for use in conjunction with the HeLa cells as per the original paper).
The Stage 1 manuscript underwent two rounds of thorough in-depth review. After considering the detailed responses to the reviewers' comments, the recommenders determined that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).
The authors have thoughtfully considered their experimental approach to the replication study, whilst acknowledging any potential limitations. Given that conducting such a replication study is novel in the field of Nanotechnology and there is currently no ‘gold standard’ approach in doing so, the authors have showed thoughtful regard of statistical analysis and unbiased methodology where possible.
Based on current information, this study is the first use of preregistration via Peer Community in Registered Reports and the first formalised replication study in Nanotechnology for Biosciences. The outcomes of this of this study will be significant both scientifically and in the wider context in discussion of the scientific method.
URL to the preregistered Stage 1 protocol: https://osf.io/qbxpf
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly Journals:
References
1. Howes, P. D., Chandrawati, R., & Stevens, M. M. (2014). Colloidal nanoparticles as advanced biological sensors. Science, 346(6205), 1247390. https://doi.org/10.1126/science.1247390
2. Liu, C. G., Han, Y. H., Kankala, R. K., Wang, S. B., & Chen, A. Z. (2020). Subcellular performance of nanoparticles in cancer therapy. International Journal of Nanomedicine, 675-704. https://doi.org/10.2147/IJN.S226186
3. Tang, W., Fan, W., Lau, J., Deng, L., Shen, Z., & Chen, X. (2019). Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics. Chemical Society Reviews, 48(11), 2967-3014. https://doi.org/10.1039/C8CS00805A
4. Yoon, Y. I., Pang, X., Jung, S., Zhang, G., Kong, M., Liu, G., & Chen, X. (2018). Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics. Journal of Materials Chemistry B, 6(20), 3235-3239. https://doi.org/10.1039%2FC8TB00368H
5. Lin, H., Chen, Y., & Shi, J. (2018). Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy. Chemical Society Reviews, 47(6), 1938-1958. https://doi.org/10.1039/C7CS00471K
6. Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021). Lipid nanoparticles for mRNA delivery. Nature Reviews Materials, 6(12), 1078-1094. https://doi.org/10.1038/s41578-021-00358-0
7. Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021). Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery, 20(2), 101-124. https://doi.org/10.1038/s41573-020-0090-8
8. Said, M., Gharib, M., Zrig, S., & Lévy, R. (2024). Replication of “Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions”. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/qbxpf
9. Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., ... & Mahmoudi, M. (2017). Cellular uptake of nanoparticles: Journey inside the cell. Chemical Society Reviews, 46(14), 4218-4244. https://doi.org/10.1039/C6CS00636A
10. de Almeida, M. S., Susnik, E., Drasler, B., Taladriz-Blanco, P., Petri-Fink, A., & Rothen-Rutishauser, B. (2021). Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine. Chemical society reviews, 50(9), 5397-5434. https://doi.org/10.1039/D0CS01127D
11. Smith, S. A., Selby, L. I., Johnston, A. P., & Such, G. K. (2018). The endosomal escape of nanoparticles: toward more efficient cellular delivery. Bioconjugate Chemistry, 30(2), 263-272. http://dx.doi.org/10.1021/acs.bioconjchem.8b00732
12. Cupic, K. I., Rennick, J. J., Johnston, A. P., & Such, G. K. (2019). Controlling endosomal escape using nanoparticle composition: current progress and future perspectives. Nanomedicine, 14(2), 215-223. https://doi.org/10.2217/nnm-2018-0326
13. Wang, Y., & Huang, L. (2013). A window onto siRNA delivery. Nature Biotechnology, 31(7), 611-612. https://doi.org/10.1038/nbt.2634
14. Zhu, A., Qu, Q., Shao, X., Kong, B., & Tian, Y. (2012). Carbon-dot-based dual-emission nanohybrid produces a ratiometric fluorescent sensor for in vivo imaging of cellular copper ions. Angewandte Chemie (International ed. in English), 51(29), 7185-7189. https://doi.org/10.1002/anie.201109089
| Replication of “Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions” | Maha Said, Mustafa Gharib, Samia Zrig, Raphaël Lévy | <p>In hundreds of articles published over the past two decades, nanoparticles have been described as probes for sensing and imaging of a variety of intracellular cytosolic targets. However, nanoparticles generally enter cells by endocytosis with o... | ![]() | Life Sciences, Medical Sciences, Physical Sciences | Emily Linnane | 2023-11-29 19:14:03 | View |
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