Ensuring universal access to sexual and reproductive health and reproductive rights is a global concern, exemplified by goal 5.6 of the Sustainable Development Goals (UN General Assembly, 2015). Whilst the range of contraceptive options have increased, our understanding of the impacts of use for women are inadequate and represent a key barrier to positive change in policies and practices. In particular, we have few consensuses on the expected impacts of hormonal contraceptive use on women's sexuality and wellbeing.

 

In the current programmatic submission, Botzet et al. (2023) argue that this inconclusive evidence base could be due to the wide heterogeneity in responses, the impacts of this heterogeneity upon attrition, differences in contraceptive methods and dosage effects, confounders, and the potential for reverse causality. Tackling some of these potential factors, Botzet (2023) explore whether hormonal contraceptive use influences sexuality and well-being outcomes, and whether (and to what extent) the effects vary between women. To achieve this they have proposed analysis of longitudinal data from the German Family Panel (PAIRFAM) which includes annual waves of data collection from >6500 women, with separate Stage 2 submissions planned to report findings based on sexuality and well-being. The proposed work will progress our understanding of the impact of hormonal contraceptives by overcoming limitations of more common research approaches in this field, and has the potential to contribute to a more contextualised view of the impact of their impacts in real-world practice.

 

The Stage 1 manuscript was evaluated over three rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).

 

 

Level of bias control achieved: Level 3: At least some of the data/evidence that will be used to answer the research question already exists AND is accessible in principle to the authors BUT the authors certify that they have not yet accessed any part of that data/evidence.

 

 

• Collabra: Psychology
• Peer Community Journal
• PeerJ
• Royal Society Open Science
• Studia Psychologica
• Swiss Psychology Open
  
  

 

Botzet, L. J., Rohrer, J. M., Penke, L. & Arslan, R. C. (2023). Hormonal Contraceptive Use and Women's Sexuality and Well-Being: Estimating Treatment Effects and Their Heterogeneity Based on Longitudinal Data. In principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/kj3h2

 

UN General Assembly (2015). Transforming our world : the 2030 Agenda for Sustainable Development, 21 October 2015, A/RES/70/1. Available at: https://www.refworld.org/docid/57b6e3e44.html [accessed 27 September 2023]

Subjective tinnitus is a common disorder in which people experience a persistent sound in the absence of any external source. The underlying causes of tinnitus are debated – although the condition is strongly associated with hearing loss resulting from auditory damage, much remains to be understood about the neural processes that give rise to the phantom perception. Various classes of neurophysiological theories have been proposed, including the “altered gain” model – in which neurons in the auditory pathway increase their responsiveness to compensate for reduced auditory input following hearing loss – and the “noise cancellation” model –  in which disrupted feedback connections from limbic regions are unable to tune out phantom signals. Although these theories account for much observed data, they have not been conclusively supported, and their ability to explain tinnitus is limited by the fact that hearing loss and tinnitus can arise independently and at different times.

 

In the current study, Reisinger et al. (2023) will test an emerging alternative theory based on a Bayesian predictive-coding framework (Sedley et al., 2016) in which the alteration of perceptual priors leads the auditory system to expect a sound that, if functioning normally, it should not expect. Using magnetoencephalography (MEG) in a sample of tinnitus patients (and carefully-matched controls for age, gender, and level of hearing loss), they will ask whether tinnitus is associated with anticipatory brain activation, tuned to the carrier-frequency of an expected auditory stimulus. Specifically, the authors predict that if the predictive-coding framework is correct then individuals with tinnitus should show different regularity-dependent pre-activations of carrier- frequency-specific information compared to the control group, while tone carrier-frequencies should be processed normally in tinnitus patients. They also predict that any such pre-activations should not be related to levels of reported subjective tinnitus distress, as measured with the short version of the Tinnitus Questionnaire (mini-TQ).

 

The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).

 

 

Level of bias control achieved: Level 3. At least some data/evidence that will be used to the answer the research question has been previously accessed by the authors (e.g. downloaded or otherwise received), but the authors certify that they have not yet observed ANY part of the data/evidence.

 

 

• Brain and Neuroscience Advances
• Cortex
• F1000Research
• In&Vertebrates
• NeuroImage: Reports
• Peer Community Journal
• PeerJ
• Psychology of Consciousness: Theory, Research and Practice
• Royal Society Open Science

 

 

Reisinger, L., Demarchi, G., Rösch, , S., Trinka, E., Obleser, L., & Weisz, N.  (2023). Registered Report: Are anticipatory predictions enhanced in tinnitus and independent of hearing loss? In principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/6gvpy

 

Sedley, W., Friston, K. J., Gander, P. E., Kumar, S., & Griffiths, T. D. (2016). An integrative tinnitus model based on sensory precision. Trends in Neurosciences, 39, 799-812. https://doi.org/10.1016/j.tins.2016.10.004

Borderline personality disorder (BPD) is a mental illness affecting ~1 in 100 people (Ellison et al., 2018), characterised by emotional dysregulation, impulsivity, a distorted sense of self, and a long-term pattern of unstable interpersonal relationships. Among this heterogenous range of symptoms is difficulty in the cognitive dimension of empathy, in particular understanding the perspectives of others, which in turn has been suggested to rely on the mirror neuron system, both in the motor and somatosensory domains. The integrity of the mirror system has therefore been a focus for understanding the possible causes or consequences of the disorder, with preliminary studies pointing to hypoactivity of neuronal areas associated with the mirror system in BPD (Mier et al., 2013).

 

In the current study, Zazio et al. (2023) will use crossmodal paired associative stimulation (cm-PAS) in which an image of a hand being touched is repeatedly paired with transcranial magnetic stimulation (TMS) of the primary somatosensory cortex (S1) to test the hypothesis that BPD is associated with a specific deficit in the tactile mirror system. In healthy controls, the close temporal coupling (20ms) between the visual depiction of tactile stimulation and TMS of S1 is expected boost tactile acuity and elevate the performance cost of incongruence in a task that manipulates visuo-tactile spatial congruity (VTSC) – effects that are thought to reflect the fidelity of the tactile mirror system.

 

In BPD patients, however, the authors make the crucial prediction that impairment of the tactile mirror system (if present) will lead to a reduced (or even non-existent) effect of cm-PAS on tactile acuity and VTSC task performance compared to healthy controls. To help ensure a severe test of this hypothesis, the design includes a variety of controls, including an attention check, control cm-PAS in which the inter-stimulus interval is increased to 100ms to break the close temporal coupling between visual stimulation and TMS, and a positive control to confirm that active cm-PAS (compared to control cm-PAS) produces the expected boost in tactile acuity in healthy controls.

 

The Stage 1 manuscript was evaluated over three rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).

 

URL to the preregistered Stage 1 protocol: https://osf.io/sqnwd
 
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
 
List of eligible PCI RR-friendly journals:
 

References
 

1. Ellison, W. D., Rosenstein, L. K., Morgan, T. A., & Zimmerman, M. (2018). Community and clinical epidemiology of borderline personality disorder. Psychiatric Clinics, 41, 561-573. https://doi.org/10.1016/j.psc.2018.07.008

2. Mier, D., Lis, S., Esslinger, C., Sauer, C., Hagenhoff, M., Ulferts, J., Gallhofer, B. & Kirsch, P. (2013). Neuronal correlates of social cognition in borderline personality disorder. Social Cognitive and Affective Neuroscience, 8, 531-537. https://doi.org/10.1093/scan/nss028

 

2. Zazio, A., Guidali, G., Rossi, R., Bolognini, N. & Bortoletto, A. (2023). Cortical plasticity of the tactile mirror system in borderline personality disorder, in principle acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/sqnwd

Many products that can impact upon health and wellbeing (e.g., alcohol, food) relay information to consumers about the potential risks. However, such information is commonly provided in suboptimal format for gambling-related products. To encourage safer gambling, research has therefore recommended that information about the average loss from a gambling product (“house edge”) or percentage payout (“return-to-player”) should be communicated, with the former translating to better perceived understanding by gamblers. This Registered Report aimed to experimentally compare two phrasings of the house edge against a control return-to-player to arrive at the most effective phrasing to aid gambler’s perceived chances of winning and their factual understanding of the statistical outcomes of their bet. Using a hypothetical gambling scenario, a sample of 3,333 UK-based online gamblers received one of three phrasings: an original house-edge (“his game keeps 10% of all money bet on average”), an alternative house-edge (“on average this game is programmed to cost you 10% of your stake on each bet”) or return-to-player (“this game has an average percentage payout of 90%”). Two outcome measures were employed to judge the effectiveness of this information: gamblers’ perceived changes of winning and factual understanding. The findings indicate that the two-house edge formats were more effective in communicating gambling-related harms than the return-to-player format, but the original house edge phrasing appeared to be the most optimal as it decreased gambler’s perceived chances of winning and increased their factual understanding compared to return-to-player. These results can therefore inform public health policies to reduce gambling-related harm by presenting the most effective communication of gambling risk.

 

After two in-depth reviews, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.

 

URL to the preregistered Stage 1 protocol: https://osf.io/5npy9
 
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA. 
 
List of eligible PCI RR-friendly journals:
 

References
  
1. Newall, P. W. S., James, R. J. E. & Maynard, O. M. (2023). How does the phrasing of house edge information affect gamblers’ perceptions and level of understanding? A Registered Report. Acceptance of Version 2 by Peer Community in Registered Reports. https://doi.org/10.31234/osf.io/pfnzd

Numeracy – the ability to understand and work with numbers – is associated with a wide range of social and health-related outcomes, including socioeconomic status, employment, literacy, reasoning, and life satisfaction. A substantial body of evidence has also shown links between numeracy and decision-making, prompting the question of how it relates to finer-grained measures of reasoning, judgment and affect/emotion.

 

In the current study, Zhu and Feldman repeated four influential experiments from a study by Peters et al. (2006), which reported links between numeracy and performance on a variety of decision-making tasks, including attribute framing, frequency-percentage framing, susceptibility to affective influences, and various cognitive biases. The authors also explored several extended questions, including refinements of the original hypotheses and an examination of the relationship between numeracy and confidence in numeric judgments (subjective numeracy).

 

The results broadly constitute a successful replication, with higher numeracy associated with weaker attribute framing and susceptibility to bias. The relationship between numeracy and the frequency-percentage framing effect – that is, the change in decision-making when numbers are presented as frequencies (e.g. 5 out of 100) rather than percentages (e.g. 5%) – was inconclusive for the main analysis that treated numeracy as a categorical variable (low vs. high); however the link emerged reliably in exploratory analyses that considered numeracy as a continuous variable. The outcomes of the extended analyses were mixed, revealing evidence for a potentially weak relationship between numeracy and confidence.

 

The Stage 2 manuscript was evaluated over one round of in-depth review. Based on detailed responses to the reviewer's comments, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
 

URL to the preregistered Stage 1 protocol: https://osf.io/r73fb

 

Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA. 

 

 

 

 

1. Zhu, M. & Feldman, G. (2022). Revisiting the links between numeracy and decision making: Replication Registered Report of Peters et al. (2006) with an extension examining confidence. Acceptance of Version 5 by Peer Community in Registered Reports. https://osf.io/62wqb

 

2. Peters, E., Västfjäll, D., Slovic, P., Mertz, C. K., Mazzocco, K., & Dickert, S. (2006). Numeracy and decision making. Psychological Science, 17, 407-413. https://doi.org/10.1111%2Fj.1467-9280.2006.01720.x