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Latest recommendations
Id | Title * | Authors * | Abstract * | Picture | Thematic fields * | Recommender | Reviewers | Submission date | |
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How does the phrasing of house edge information affect gamblers’ perceptions and level of understanding? A Registered ReportPhilip Newall, Richard James, Olivia Maynard https://doi.org/10.31234/osf.io/pfnzdDoes relaying ‘house edge’ information influence gambler’s perceived chances of winning and their factual understanding of the statistical outcomes?Recommended by Charlotte Pennington based on reviews by Zhang Chen and Graeme KnibbMany products that can impact upon health and wellbeing (e.g., alcohol, food) relay information to consumers about the potential risks. However, such information is commonly provided in suboptimal format for gambling-related products. To encourage safer gambling, research has therefore recommended that information about the average loss from a gambling product (“house edge”) or percentage payout (“return-to-player”) should be communicated, with the former translating to better perceived understanding by gamblers. This Registered Report aimed to experimentally compare two phrasings of the house edge against a control return-to-player to arrive at the most effective phrasing to aid gambler’s perceived chances of winning and their factual understanding of the statistical outcomes of their bet. Using a hypothetical gambling scenario, a sample of 3,333 UK-based online gamblers received one of three phrasings: an original house-edge (“his game keeps 10% of all money bet on average”), an alternative house-edge (“on average this game is programmed to cost you 10% of your stake on each bet”) or return-to-player (“this game has an average percentage payout of 90%”). Two outcome measures were employed to judge the effectiveness of this information: gamblers’ perceived changes of winning and factual understanding. The findings indicate that the two-house edge formats were more effective in communicating gambling-related harms than the return-to-player format, but the original house edge phrasing appeared to be the most optimal as it decreased gambler’s perceived chances of winning and increased their factual understanding compared to return-to-player. These results can therefore inform public health policies to reduce gambling-related harm by presenting the most effective communication of gambling risk.
After two in-depth reviews, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/5npy9
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA. List of eligible PCI RR-friendly journals:
References
1. Newall, P. W. S., James, R. J. E. & Maynard, O. M. (2023). How does the phrasing of house edge information affect gamblers’ perceptions and level of understanding? A Registered Report. Acceptance of Version 2 by Peer Community in Registered Reports. https://doi.org/10.31234/osf.io/pfnzd | How does the phrasing of house edge information affect gamblers’ perceptions and level of understanding? A Registered Report | Philip Newall, Richard James, Olivia Maynard | <p>The provision of information to consumers is a common input to tackling various public health issues. By comparison to the information given on food and alcohol products, information on gambling products is either not given at all, or shown in ... | Social sciences | Charlotte Pennington | Zhang Chen | 2023-01-09 14:56:36 | View | |
19 Mar 2023
STAGE 1
How does the phrasing of house edge information affect gamblers’ perceptions and level of understanding? A Registered ReportPhilip Newall, Richard James, Olivia Maynard https://osf.io/zf4c8Does relaying ‘house edge’ information influence gambler’s perceived chances of winning and their factual understanding of the statistical outcomes?Recommended by Charlotte Pennington based on reviews by Zhang Chen, Graeme Knibb and Luke ClarkeMany products that can impact upon health and wellbeing (e.g. alcohol, food) relay information to consumers about the potential risks. However, such information is commonly provided in suboptimal format for gambling-related products. To encourage safer gambling, research has therefore recommended that information about the average loss from a gambling product (“house edge”) or percentage payout (“return-to-player”) should be communicated, with the former translating to better perceived understanding by gamblers. In this study, Newall et al. (2022) aim to experimentally compare two phrasings of the house edge against a control return-to-player to arrive at the most effective phrasing to aid gambler’s perceived chances of winning and their factual understanding of the statistical outcomes of their bet. Using a hypothetical gambling scenario, a sample of 3,000 UK-based online gamblers will be randomly assigned to receive two alternative phrasings of the house edge or the equivalent return-to-player information. Two outcome measures will be used to judge the effectiveness of the house edge information: gamblers’ perceived changes of winning and rates of accurate responding on a multiple-choice question measuring factual understanding of this information. This study will therefore assess the most effective communication of gambling risk, which can inform public health policies to reduce gambling-related harm.
Following a positive initial appraisal, and after two rounds of in-depth review, the recommender judged that the manuscript met the Stage 1 criteria and awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/5npy9
Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA. List of eligible PCI RR-friendly journals:
References
1. Newall, P. W. S., James, R. J. E. & Maynard, O. M. (2022). How does the phrasing of house edge information affect gamblers’ perceptions and level of understanding? A Registered Report, in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/5npy9 | How does the phrasing of house edge information affect gamblers’ perceptions and level of understanding? A Registered Report | Philip Newall, Richard James, Olivia Maynard | <p>The provision of information to consumers is a common input to tackling various public health issues. By comparison to the information given on food and alcohol products, information on gambling products is either not given at all, or shown in ... | Social sciences | Charlotte Pennington | 2022-07-18 16:25:06 | View | ||
Causal evidence for the role of the sensory visual cortex in visual short-term memory maintenancePhivos Phylactou; Andria Shimi; Nikos Konstantinou https://doi.org/10.31234/osf.io/64hdxThe visual cortex can maintain information for up to a secondRecommended by Zoltan Dienes based on reviews by Evie Vergauwe and Vincent van de VenAccording to the sensory recruitment framework, the visual cortex is at least in part responsible for maintaining information about elementary visual features in visual short term memory. Could an early visual area, constantly taking in new information, really be responsible for holding information for up to a second? But conversely, could higher order regions, such as frontal regions, really hold subtle sensory distinctions? It must be done somewhere. Yet the existing evidence is conflicting. Phylactou et al. addressed this question by applying transcranial magnetic stimulation (TMS) to disrupt early visual areas at intervals up to a second after stimulus presentation to determine the effect on visual short term memory performance. In this way, they causally influenced the sensory cortex at relevant times while tightening up on possible confounds in earlier research.
They found that TMS applied to the occipital hemisphere at each of 200ms and 1000ms after presentation of a brief visual stimulus disrupted stimuls detection on a visual short term memory test. These findings support sensory recruitment, which claims that both perceptual and memory processes rely on the same neural substrates in the visual cortex.
The Stage 2 manuscript was evaluated by two expert reviewers. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 2 criteria for recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/empdt
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after Stage 1 IPA. List of eligible PCI RR-friendly journals:
References
1. Phylactou, P., Shimi, A. & Konstantinou, N. (2023). Causal evidence for the role of the sensory visual cortex in visual short-term memory maintenance, acceptance of Version 13 by Peer Community in Registered Reports. https://doi.org/10.31234/osf.io/64hdx
| Causal evidence for the role of the sensory visual cortex in visual short-term memory maintenance | Phivos Phylactou; Andria Shimi; Nikos Konstantinou | <p>The role of the sensory visual cortex during visual short-term memory (VSTM) remains controversial. This controversy is possibly due to methodological issues in previous attempts to investigate the effects of transcranial magnetic stimulation (... | Social sciences | Zoltan Dienes | 2023-01-03 08:47:59 | View | ||
Beneath the label: Unsatisfactory compliance with ESRB, PEGI, and IARC industry self-regulation requiring loot box presence warning labels by video game companiesLeon Y. Xiao https://doi.org/10.31219/osf.io/asbcgFailure of industry self-regulation in loot box labellingRecommended by Chris ChambersPaid loot boxes – items bought for real-world money that offer randomised rewards – are a prevalent feature of contemporary video games (Zendle et al., 2020). Because they employ random chance to provide rewards after spending real money, loot boxes have been considered a form of gambling, raising concerns about risk of harm to children and other vulnerable users. In response, some countries have taken legal steps to regulate and even ban the use of loot boxes, with only limited success so far (Xiao, 2022). At the same time, the Entertainment Software Rating Board (ESRB) and PEGI (Pan-European Game Information) now expect games that contain loot boxes to be marked with warning labels that, in theory, will enable users (including parents) to make more informed decisions. These requirements by ESRB/PEGI are not legally binding and may be considered a form of industry self-regulation.
In the current study, Xiao (2023) investigated the effectiveness of self-regulation in the use of loot box labels. Study 1 examined the consistency of warning labels by the ESRB and PEGI, with the expectation that if self-regulation works as it should then these labels should always (or nearly always) co-occur. Study 2 established the compliance rate for labelling among popular games that are known to contain loot boxes, with a rate of ≥95% considered to be successful.
The results of both studies reveal deficiences in industry self-regulation. The consistency rate of warning labels by the ESRB and PEGI was just 39.4% in preregistered analyses, rising to 83.9% in an unregistered exploratory analysis that took into account industry responses to the findings. Even at this upper bound, this rate is lower than expected by complete (or near-complete) consistency. The results of Study 2 indicate that only 29% of games on the Google Play Store known to contain loot boxes were accurately labelled, indicating that 71% were non-compliant with industry requirements.
Following careful evaluation, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/e6qbm Level of bias control achieved: Level 3. At least some data/evidence that was used to the answer the research question had been previously accessed by the authors (e.g. downloaded or otherwise received), but the authors certifed that they had not yet observed ANY part of the data/evidence prior to in-principle-acceptance.
List of eligible PCI RR-friendly journals:
References
1. Zendle, D., Meyer, R., Cairns, P., Waters, S., & Ballou, N. (2020). The prevalence of loot boxes in mobile and desktop games. Addiction, 115(9), 1768-1772. https://doi.org/10.1111/add.14973
2. Xiao, L. Y. (2022). Breaking Ban: Belgium’s ineffective gambling law regulation of video game loot boxes. Stage 2 Registered Report, acceptance of Version 2 by Peer Community in Registered Reports. https://doi.org/10.31219/osf.io/hnd7w 3. Xiao, L. Y. (2023). Beneath the label: Unsatisfactory compliance with ESRB, PEGI, and IARC industry self-regulation requiring loot box presence warning labels by video game companies, acceptance of Version 2 by Peer Community in Registered Reports. https://doi.org/10.31219/osf.io/asbcg
| Beneath the label: Unsatisfactory compliance with ESRB, PEGI, and IARC industry self-regulation requiring loot box presence warning labels by video game companies | Leon Y. Xiao | <p>Loot boxes in video games are a form of in-game transactions with randomised elements. Concerns have been raised about loot boxes’ similarities with gambling and their potential harms (e.g., overspending). Recognising players’ and parents’ conc... | Humanities, Social sciences | Chris Chambers | Jim Sauer, Pete Etchells | 2023-02-12 16:17:34 | View | |
Sight vs. sound judgments of music performance depend on relative performer quality: Cross-cultural evidence from classical piano and Tsugaru shamisen competitions [Stage 2 Registered Report]Gakuto Chiba, Yuto Ozaki, Shinya Fujii, Patrick E. Savage https://doi.org/10.31234/osf.io/xky4jMusic is appreciated cross-modally, but is culture- and context-dependentRecommended by Yuki Yamada based on reviews by Kyoshiro Sasaki and 1 anonymous reviewerMusic is not merely limited to the aural experience we garner through our auditory faculties, as commonly perceived. Rather, various studies have explored the cross-modal impact of visual stimuli on the evaluation of music. These previous studies have been confined exclusively to Western music. Hence, Chiba et al. (2023) designed a study with a focus on the Tsugaru shamisen, a renowned folk instrument indigenous to Japan, and of which the first author is an outstanding player.
The study methodology was an improved version of previous endeavors, wherein actual musical material sourced from concours performances was displayed through audio-only, video-only or both modalities. A sample of Japanese participants were then asked to evaluate the concours performances on both the piano and the Tsugaru shamisen. The results, obtained through pre-registered protocols, revealed that for both concours performances, the participants displayed a cross-modal impact of visual information on their aural evaluation of music. This effect was also found to be contingent on cultural and contextual factors. These outcomes furnish valuable evidence towards the generalizability of the interplay between sight and sound in the assessment of music. The study underwent rigorous peer-review processes in both Stage 1 and Stage 2, with three experts specializing in Japanese folk music, open science, and statistics, respectively, providing their critical assessments. Following multiple rounds of revision, the final manuscript was deemed fit for recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/ry2b6
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA.
List of eligible PCI RR-friendly journals:
References
Chiba G., Ozaki Y., Fujii S., & Savage P.E. (2023). Sight vs. sound judgments of music performance depend on relative performer quality: Cross-cultural evidence from classical piano and Tsugaru shamisen competitions [Stage 2 Registered Report]. Acceptance of Version 2 by Peer Community in Registered Reports. https://doi.org/10.31234/osf.io/xky4j
| Sight vs. sound judgments of music performance depend on relative performer quality: Cross-cultural evidence from classical piano and Tsugaru shamisen competitions [Stage 2 Registered Report] | Gakuto Chiba, Yuto Ozaki, Shinya Fujii, Patrick E. Savage | <p>Which information dominates in evaluating performance in music? Both experts and laypeople consistently report believing that sound should be the most important domain when judging music competitions, but experimental studies of Western partici... | Social sciences | Yuki Yamada | 2022-11-30 08:04:37 | View | ||
The labels and models used to describe problematic substance use impact discrete elements of stigma: A Registered ReportCharlotte R. Pennington, Rebecca L. Monk, Derek Heim, Abi K. Rose, Thomas Gough, Ross Clarke, Graham Knibb, Roshni Patel, Priya Rai, Halimah Ravat, Ramsha Ali, Georgiana Anastasiou, Fatemeh Asgari, Eve Bate, Tara Bourke, Jayme Boyles, Alix Campbell, Nic Fowler, Sian Hester, Charlotte Neil, Beth McIntyre, Ellie Ogilvy, Amie Renouf, Joni Stafford, Katie Toothill, Hin Kok Wong, Andrew Jones https://doi.org/10.17605/OSF.IO/DK694Different ways of describing problematic substance use and its treatment influence public stigmaRecommended by Zoltan Dienes based on reviews by Nicholas Sinclair-HousePeople experiencing problematic substance use are often stigmatised by the general public. This public stigma may impair such people obtaining help and the quality of help that they receive. For this reason, previous research has investigated the factors that may exacerbate or lessen stigma by focusing on the terminology used to describe problematic substance use. However, the evidence is not clear cut, with some studies suggesting that labelling the condition as a "chronically relapsing brain disease" vs a "problem" reduces certain elements of stigma and other studies finding absence of evidence. A closer look at these studies points to methodological differences that may explain their results, such as whether problematic substance use is compared with another health condition, whether the individual is described as seeking treatment or not, and whether general or discrete elements of stigma are measured.
In this Stage 2 Registered Report, Pennington et al. (2023) isolated these methodological differences to investigate if any of them influenced two different measures of stigma used in previous work. They found that greater social distance, danger and public stigma but lower blame were ascribed to drug use relative to a health concern, supporting previous research to suggest that problematic substance use is a highly stigmatised health condition. Furthermore, greater (genetic) blame was reported when drug use was labelled as a ‘chronically relapsing brain disease’ relative to a ‘problem’. The results for attributional judgement were either inconclusive or statistically equivalent. In summary, these findings suggest that the labels and models used to describe problematic substance use may impact upon public stigma in distinct ways. The authors suggest that future research should justify which measures are being used in line with theory. They also put forward the notion that addiction is a functional attribution, which may explain the mixed literature on the brain disease model of addiction to date.
The Stage 2 manuscript was evaluated over one round of specialist review and several rounds of discussion with the recommender. Based on comprehensive responses, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/4vscg
Level of bias control achieved: Level 6. No part of the data or evidence that was used to answer the research question was generated until after IPA.
List of eligible PCI RR-friendly journals:
References
Pennington, C. R., Monk, R. L., Heim, D., Rose, A. K., Gough, T., Clarke, R., Knibb, G., Patel, R., Rai, P., Ravat, H., Ali, R., Anastasiou, G., Asgari, F., Bate, E., Bourke, T., Boyles, J., Campbell, A., Fowler, N., Hester, S., Neil, C., McIntrye, B., Ogilvy, E., Renouf, A., Stafford, J., Toothill, K., Wong, H. K., & Jones, A. (2023). The labels and models used to describe problematic substance use impact discrete elements of stigma: A Registered Report. Stage 2 acceptance of Version 4 by Peer Community in Registered Reports. https://osf.io/z9bnf
| The labels and models used to describe problematic substance use impact discrete elements of stigma: A Registered Report | Charlotte R. Pennington, Rebecca L. Monk, Derek Heim, Abi K. Rose, Thomas Gough, Ross Clarke, Graham Knibb, Roshni Patel, Priya Rai, Halimah Ravat, Ramsha Ali, Georgiana Anastasiou, Fatemeh Asgari, Eve Bate, Tara Bourke, Jayme Boyles, Alix Campbel... | <p>Objectives: Problematic substance use is one of the most stigmatised health conditions leading research to examine how the labels and models used to describe it influence public stigma. Two recent studies examine whether beliefs in a disease mo... | Social sciences | Zoltan Dienes | 2022-10-21 16:13:49 | View | ||
Neuroanatomical Correlates of System-justifying Ideologies: A Pre-registered Voxel-based Morphometry Study on Right-Wing Authoritarianism and Social Dominance OrientationJan Paolo M. Balagtas, Serenella Tolomeo, Bindiya L. Ragunath, Paola Rigo, Marc H. Bornstein & Gianluca Esposito https://doi.org/10.17605/OSF.IO/9AEBGNo definitive evidence for neuroanatomical correlates of system-justifying ideologiesRecommended by Chris Chambers based on reviews by Bonni Crawford and 1 anonymous reviewerAccording to the tenets of system justification theory, system-justifying ideologies are beliefs held by individuals to defend and justify the status quo, even when doing do perpetuates social inequalities (Jost and Hunyady, 2005). Two such well-studied ideologies to emerge from political science and social psychology are social dominance orientation (SDO) – the belief that some social groups are superior to others – and right wing authoritarianism (RWA) – the belief that people should follow conventional traditions and authorities, avoiding rebellious ideas. Although considered to be stable traits that may have a heritable basis, there has been little investigation of the neural correlates of SDO and RWA, and it remains unknown whether they are associated with common or distinct brain systems.
In the current study, Balagtas et al. report a novel investigation of the neuroanatomical correlates of both SDO and RWA in a Chinese Singaporean sample using voxel-based morphometry. Based on previous research, the authors chose to focus especially on relationships between SDO, RWA and the volume of the amygdala, ventromedial prefrontal cortex, and anterior insula.
As predicted, the results showed a reliable positive correlation between measures of RWA and SDO; however, none of the neuroanatomical hypotheses were fully supported. Preregistered whole brain analyses revealed no significant regions associated with either RWA or SDO, while ROI analyses identified overlapping (including the amygdala and ventromedial prefrontal cortex) and non-overlapping regions (including left anterior insula) associated with RWA and SDO. Exploratory robustness checks suggested that the authors' spherical ROI localisation method may have identified clusters that were not within the amygdala or left anterior insula, prompting the need for future replication in a larger sample using more precise, atlas-based analyses.
The Stage 2 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 2 criteria and awarded a positive recommendation.
URL to the preregistered Stage 1 protocol: https://osf.io/btkwq
Level of bias control achieved: Level 4. At least some of the data/evidence that was used to answer the research question already existed AND was accessible in principle to the authors (e.g. residing in a public database or with a colleague) BUT the authors certified that they had not yet accessed any part of that data/evidence prior to IPA.
List of eligible PCI RR-friendly journals:
References
1. Jost, J. T., & Hunyady, O. (2005). Antecedents and consequences of system-justifying ideologies. Current Directions in Psychological Science, 14, 260-265. https://doi.org/10.1111%2Fj.0963-7214.2005.00377.x
2. Balagtas, P. M., Tolomeo, S., Ragunath, B., Rigo, P., Bornstein, M. H. & Esposito, G. (2023). Neuroanatomical Correlates of System-justifying Ideologies: A Pre-registered Voxel-based Morphometry Study on Right-Wing Authoritarianism and Social Dominance Orientation. Stage 2 Registered Report, acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/nrqtz
| Neuroanatomical Correlates of System-justifying Ideologies: A Pre-registered Voxel-based Morphometry Study on Right-Wing Authoritarianism and Social Dominance Orientation | Jan Paolo M. Balagtas, Serenella Tolomeo, Bindiya L. Ragunath, Paola Rigo, Marc H. Bornstein & Gianluca Esposito | <p>System-justifying ideologies are a cluster of ideals that perpetuate a hierarchical social system despite being fraught with inequalities. Right Wing Authoritarianism (RWA) and Social Dominance Orientation (SDO) are two ideologies that have rec... | Social sciences | Chris Chambers | 2022-07-27 17:53:26 | View | ||
09 Feb 2023
STAGE 1
The Medusa effect: A registered replication report of Will, Merritt, Jenkins, and Kingstone (2021)Jing Han, Minjun Zhang, Jiaxin Liu, Yu Song, Yuki Yamada https://osf.io/bjt37Looking (again) at Medusa: does pictorial abstraction influence mind perception?Recommended by Chris Chambers based on reviews by Alan Kingstone, Brittany Cassidy and 3 anonymous reviewersThe Medusa effect is a recently described phenomenon in which people judge a person to be more mindful when they appear as a picture than as a picture within a picture. Across a series of experiments, Will et al. (2021) reported that at higher levels of abstraction, images of people were judged lower in realness (how real the person seemed), experience (the ability to feel) and agency (the ability to plan and act), and also benefited less from prosocial behaviour. The findings provide an intriguing window into mind perception – the extent to which we attribute minds and mental capacities to others.
In the current study, Han et al. (2023) propose a close replication of two experiments from the original report by Will et al. (2021), asking first, whether the level of pictorial abstraction influences ratings of realness, agency and experience, and second, whether it also influences prosocial behaviour as measured in the dictator game (with participants predicted to allocate more money to recipients presented as pictures than as pictures within pictures). In the event of a non-replication using the original materials, the authors will further repeat the experiments using newly generated stimuli that are better matched for cultural context and more tightly controlled along various dimensions.
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/xj46z Level of bias control achieved: Level 6. No part of the data or evidence that will be used to answer the research question yet exists and no part will be generated until after IPA.
List of eligible PCI RR-friendly journals: References
1. Will, P., Merritt, E., Jenkins, R., & Kingstone, A. (2021). The Medusa effect reveals levels of mind perception in pictures. Proceedings of the National Academy of Sciences, 118(32), e2106640118. https://doi.org/10.1073/pnas.2106640118
2. Han, J., Zhang, M., Liu, J., Song, Y. & Yamada, Y. (2023).The Medusa effect: A registered replication report of Will, Merritt, Jenkins, and Kingstone (2021), in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/xj46z
| The Medusa effect: A registered replication report of Will, Merritt, Jenkins, and Kingstone (2021) | Jing Han, Minjun Zhang, Jiaxin Liu, Yu Song, Yuki Yamada | <div>The medusa effect refers to the tendency of people to evaluate a "picture of a person" as more mindful than a "picture of a picture of a person". This phenomenon is strikingly intriguing because it suggests that when people evaluate the human... | Social sciences | Chris Chambers | Anonymous, Alan Kingstone, Anonymous, Anonymous | 2022-08-18 09:50:35 | View | |
06 Feb 2023
STAGE 1
Investigating the impact of vascular risk factors on the progression of white matter lesionsFrauke Beyer,Laurenz Lammer, Markus Loeffler, Steffi Riedel-Heller, Arno Villringer, Veronica Witte https://osf.io/phctkUnderstanding predictors of white matter lesions in the human brainRecommended by Chris Chambers based on reviews by Max Elliott, Isabel Garcia Garcia and 1 anonymous reviewerCerebral small vessel disease (CSVD) is a common and multi-faceted set of pathologies that affect the small arteries, arterioles, venules and capillaries of the brain. The disease manifests through a range of symptoms and conditions, including psychiatric disorders, abnormal gait, and urinary incontinence, while accounting for 25% of strokes and nearly 50% of dementia.
The presence of CSVD is associated with white matter lesions (WML) detected using neuroimaging, which have in turn been shown to predict future stroke, cognitive decline and dementia. While vascular risk factors of CSVD (such as hypertension and obesity) are also associated with CSVD, a complete picture of the predictive relationship between WML, cognitive decline, and blood pressure remains to be determined, as does the role of sex/gender. These inter-relationships are important to determine for improving the diagnosis and treatment of CSVD.
In the current study, Beyer et al. will analyse a large emerging dataset from the LIFE-Adult project – a longitudinal, two-wave, population-based study – to ask whether higher blood pressure predicts a greater increase in WML, and whether progression of WML is associated with measures of memory and executive function. In addition, the authors will explore the relationship between abdominal obesity and WML progression, and the extent to which WML progression, and its interaction with vascular risk factors, depends on sex/gender.
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/qkbgj Level of bias control achieved: Level 2. At least some data/evidence that will be used to answer the research question has been accessed and partially observed by the authors, but the authors certify that they have not yet observed the key variables within the data that will be used to answer the research question.
List of eligible PCI RR-friendly journals:
References
1. Beyer, F., Lammer, L., Loeffler, M., Riedel-Heller, S., Villringer, A. & Witte, V. (2023). Investigating the impact of vascular risk factors on the progression of white matter lesions, in principle acceptance of Version 2 by Peer Community in Registered Reports. https://osf.io/qkbgj
| Investigating the impact of vascular risk factors on the progression of white matter lesions | Frauke Beyer,Laurenz Lammer, Markus Loeffler, Steffi Riedel-Heller, Arno Villringer, Veronica Witte | <p>Cerebral small vessel disease (cSVD) is a major brain pathology contributing to cognitive decline and dementia. Vascular risk factors have been associated with imaging markers of cSVD such as white matter lesions, yet longitudinal studies have ... | Life Sciences | Chris Chambers | Max Elliott, Isabel Garcia Garcia | 2022-10-07 13:44:11 | View | |
23 Jan 2023
STAGE 1
Genetically-modified animals as models of neurodevelopmental conditions: an umbrella reviewEmma Wilson; Gillian Currie; Malcolm Macleod; Peter Kind; Emily S Sena https://osf.io/4xvgpEvaluating the quality of systematic reviews in preclinical animal studies of neurodevelopmental conditionsRecommended by Chris Chambers based on reviews by Marietta Papadatou-Pastou and Richel BilderbeekSingle gene alterations have been estimated to account for nearly half of neurodevelopmental conditions (NDCs), providing a crucial opportunity for animal models to understand the underlying mechanisms, causes and potential treatments. The use of systematic reviews (SRs) can, in principle, provide a powerful means to synthesise this evidence-base; however, the reporting quality of previous SRs in preclinical animal research has been found lacking (Hunniford et al., 2021). In the current study, Wilson et al. (2023) will undertake an umbrella review – a systematic review of systematic reviews – to assess the characteristics and reporting quality of SRs that, in turn, synthesise research in genetically-modified animals to model NDCs. In particular, the authors will extract key features of reviews (including, among others, the aim and primary research questions, relevant animal model, and number of studies in the SR), in addition to quality indicators such as risk of bias and completeness of reporting. In doing so, the authors aim to enhance guidance on the conduct and reporting of systematic reviews in this area.
The Stage 1 manuscript was evaluated over two rounds of in-depth review. Based on detailed responses to the reviewers' comments, the recommender judged that the manuscript met the Stage 1 criteria and therefore awarded in-principle acceptance (IPA).
URL to the preregistered Stage 1 protocol: https://osf.io/952qk Level of bias control achieved: Level 4. At least some of the data/evidence that will be used to answer the research question already exists AND is accessible in principle to the authors BUT the authors certify that they have not yet accessed any part of that data/evidence.
List of eligible PCI RR-friendly journals:
References
1. Hunniford V. T., Montroy J., Fergusson D. A., Avey M. T., Wever K. E., McCann S. K., Foster M., Fox G., Lafreniere M., Ghaly M., Mannell S., Godwinska K., Gentles A., Selim S., MacNeil J., Sikora L., Sena E. S., Page M. J., Macleod M., Moher D., & Lalu M. M. (2021). Epidemiology and reporting characteristics of preclinical systematic reviews. PLOS Biology, 19:e3001177. https://doi.org/10.1371/journal.pbio.3001177
2. Wilson, E., Currie, G., Macleod, M., Kind, P. & Sena, E. S. (2023). Genetically-modified animals as models of neurodevelopmental conditions: an umbrella review, in principle acceptance of Version 3 by Peer Community in Registered Reports. https://osf.io/952qk
| Genetically-modified animals as models of neurodevelopmental conditions: an umbrella review | Emma Wilson; Gillian Currie; Malcolm Macleod; Peter Kind; Emily S Sena | <p><strong>Objective</strong><br>Using genetically-modified animals to model neurodevelopmental conditions (NDCs) helps better our understanding of their underlying biology. In vivo research has unique characteristics not shared with clinical rese... | Life Sciences | Chris Chambers | 2022-08-29 12:08:51 | View |
MANAGING BOARD
Chris Chambers
Zoltan Dienes
Corina Logan
Benoit Pujol
Maanasa Raghavan
Emily S Sena
Yuki Yamada